Assessment of Radiation Injury (Biodosimetry)

Uniformed Services University

Assessment of Radiation Injury (Biodosimetry)

After a suspected radiation injury, it is vital to determine the extent of actual injury to determine treatment or disposition. The goals of the Biodosimetry Program are to develop rapid, precise methods to assess the severity of radiation injury as early as possible after the event. These methods will aid in the triage of personnel during a radiological scenario. They will guide treatment decisions, and aid in monitoring recovery from injury and effectiveness of treatments.

The gold standard for biodosimetry has been cytogenetics (analysis of chromosomal abnormalities), including dicentric assays. To increase throughput during mass casualty scenarios, AFRRI has been working on identifying novel biomarkers amenable to accelerated analysis of noninvasive samples.

To increase precision, multiparameter assessment has been a recent focus of AFRRI’s program, together with development of prognostic algorithms using these data. AFRRI has been working with corporate partners to devise deployable platforms incorporating both detection processes and software. Software developed by AFRRI staff has been deployed to DOD websites to aid in assessment of radiation injury severity by integrating a variety of medical data available to health workers in the field.