AFRRI Publications starting in 2014 (missing volume and page numbers indicate publication is in press)
Bardack, S., C. L. Dalgard, J. F. Kalinich and C. E. Kasper (2014). Genotoxic changes to rodent cells exposed in vitro to tungsten, nickel, cobalt and iron. Int J Environ Res Public Health 11(3): 2922-2940 DOI: 10.3390/ijerph110302922.
Blakely, W. F., D. J. Sandgren, V. Nagy, S. Y. Kim, G. B. Sigal and N. I. Ossetrova (2014). Further biodosimetry investigations using murine partial-body irradiation model. Radiat Prot Dosimetry 159(1-4): 46-51 DOI: 10.1093/rpd/ncu127.
Blancato, J., A. Graves, B. Rashidi, M. Moroni, L. Tchobe, M. Ozdemirli, B. Kallakury, K. H. Makambi, C. Marian and S. C. Mueller (2014). SYK allelic loss and the role of Syk-regulated genes in breast cancer survival. PLoS ONE 9(2) DOI: 10.1371/journal.pone.0087610.
Blumenthal, D. J., S. L. Sugarman, D. M. Christensen, A. L. Wiley, G. K. Livingston, E. S. Glassman, J. F. Koerner, J. M. Sullivan and S. Hinds (2014). Role of dicentric analysis in an overarching biodosimetry strategy for use following a nuclear detonation in an urban environment. Health Physics 106(4): 516-522 DOI: 10.1097/HP.0b013e3182a5f94f.
Bolduc, D. L., V. Villa, D. J. Sandgren, G. D. Ledney, W. F. Blakely and R. Bunger (2014). Application of multivariate modeling for radiation injury assessment: A proof of concept. Computational and Mathematical Methods in Medicine DOI: 10.1155/2014/685286.
Bolduc, D. L., R. Bünger, M. Moroni and W. F. Blakely (2016). Modeling H-ARS using hematological parameters: A comparison between the non-human primate and minipig. Radiation Protection Dosimetry DOI: 10.1093/rpd/ncw159
Cannon, G., M. A. Callahan, J. Q. Gronemus and R. J. Lowy (2014). Early activation of MAP kinases by influenza A Virus X-31 in murine macrophage cell lines. PLoS ONE 9(8) DOI: 10.1371/journal.pone.0105385.
Cary, L. H., D. Noutai, R. E. Salber, M. S. Williams, B. F. Ngudiankama and M. H. Whitnall (2014). Interactions between endothelial cells and T cells modulate responses to mixed neutron/gamma radiation. Radiation Research 181(6): 592-604 DOI: 10.1667/rr13550.1.
Cheema, A. K., R. Pathak, F. Zandkarimi, P. Kaur, L. Alkhalil, R. Singh, X. G. Zhong, S. Ghosh, N. Aykin-Burns and M. Hauer-Jensen (2014). Liver metabolomics reveals increased oxidative stress and fibrogenic potential in Gfrp transgenic mice in response to ionizing radiation. J Proteome Res 13(6): 3065-3074 DOI: 10.1021/pr500278t.
Cheema, A. A., K. Y. Mehta, O. O. Fatanmi, S. Y. Wise, C. P. Hinzman, J. W. Wolff and V. K. Singh (2018). A metabolomic and lipidomic serum signature from nonhuman primates administered with a promising radiation countermeasure, gamma-tocotrienol. International Journal of Molecular Sciences 19:79, DOI: 10.3390/ijms19010079.
Cheema A. K. , Hinzman C. P., Khyati M. Y., Hanlon B. K., Garcia M., Fatanmi O. O. and V. K. Singh (2018). Plasma derived exosomal biomarkers of exposure to ionizing radiation in nonhuman primates. International Journal of Molecular Sciences 19:3427, DOI: 10.3390/ijms19113427.
Cheema, A. K., K. Mehta, P. T. Santiago, O. O. Fatanmi, M. D. Kaytor, V. K. Singh (2019): Pharmacokinetic and metabolomic studies with BIO 300, a nanosuspension of genistein, in a nonhuman primate model. International Journal of Molecular Sciences 20:1231, DOI: org/10.3390/ijms20051231.
Cheema, A.K., K. Y. Mehta, M. U. Rajagopal, S.Y. Wise, O.O. Fatanmi V. K. Singh (2019): Metabolomic Studies of tissue injury of in nonhuman primates exposed to gamma-radiation. International Journal of Molecular Sciences ,20:3360, DOI:10.3390/ijms20133360
Cheema, A. K., Y. Li, M. Girgis, M. Jayatilake, M. Simas, S. Y. Wise, A. Q. Olabisi, T. M. Seed, V. K. Singh (2019). Metabolomic studies in tissues of mice treated with amifostine and exposed to gamma-radiation. Scientific Reports 9:15701, DOI: 10.1038/s41598-52120-w
Compadre, C. M., A. Singh, S. Thakkar, G. R. Zheng, P. J. Breen, S. Ghosh, M. Kiaei, M. Boerma, K. I. Varughese and M. Hauer-Jensen (2014). Molecular dynamics guided design of tocoflexol: A new radioprotectant tocotrienol with enhanced bioavailability. Drug Development Research 75(1): 10-22 DOI: 10.1002/ddr.21162.
Cramer, N. P., X. F. Xu, C. Christensen, A. Bierman, C. G. Tankersley and Z. Galdzicki (2015). Strain variation in the adaptation of C57Bl6 and BALBc mice to chronic hypobaric hypoxia. Physiology & Behavior 143: 158-165 DOI: 10.1016/j.physbeh.2015.01.036.
Dalgard, C. L., D. M. Jacobowitz, V. K. Singh, K. S. Saleem, R. J. Ursano, J. M. Starr and H. B. Pollard (2015). A novel analytical brain block tool to enable functional annotation of discriminatory transcript biomarkers among discrete regions of the fronto-limbic circuit in primate brain. Brain Research 1600: 42-58 DOI: 10.1016/j.brainres.2014.12.031.
Elliott, T. B., D. L. Bolduc, G. D. Ledney, J. G. Kiang, O. O. Fatanmi, S. Y. Wise, P. L. Romaine, V. L. Newman and V. K. Singh (2015). Combined immunomodulator and antimicrobial therapy eliminates polymicrobial sepsis and modulates cytokine production in combined injured mice. Int J Radiat Biol: 1-13.
Elliott, T. B., N. E. Deutz, J. Gulani, A. Koch, C. H. Olsen, C. Christensen, M. Chappell, M. H. Whitnall and M. Moroni (2014). Gastrointestinal acute radiation syndrome in Gottingen minipigs (Sus scrofa domesticus). Comparative Medicine 64(6): 456-463.
Emond, C. A., V. B. Vergara, E. D. Lombardini, S. R. Mog and J. F. Kalinich (2015). Induction of rhabdomyosarcoma by embedded military-grade tungsten/nickel/cobalt not by tungsten/nickel/iron in the B6C3F(1) Mouse. International Journal of Toxicology 34(1): 44-54 DOI: 10.1177/1091581814565038.
Emond, C. A., V. B. Vergara, E. D. Lombardini, S. R. Mog and J. F. Kalinich (2015). The role of the component metals in the toxicity of military-grade tungsten alloy. Toxics 3: 499-514 DOI: doi:10.3390/toxics3040499.
Farahani, M., M. C. Clochard, I. Gifford, A. Barkatt and M. Al-Sheikhly (2014). Differences in fundamental reaction mechanisms between high and low-LET in recent advancements and applications of ionizing radiation. Radiation Physics and Chemistry 105: 39-47 DOI: 10.1016/j.radphyschem.2014.05.032.
Fendler W., B. Malachowska, K. Meghani, P. A. Konstantinopoulos, C. Guha, V. K. Singh and C. Chowdhury (2017). Evolutionarily conserved serum microRNAs can predict radiation-induced fatality in non-human primates. Science Translational Medicine 9:eaal2408, DOI: 10.1126/scitranslmed.aal2408.
Fukumoto, R., T. M. Burns and J. G. Kiang (2014). Ciprofloxacin enhances stress erythropoiesis in spleen and increases survival after whole-body irradiation combined with skin-wound trauma. PLoS ONE 9(2) DOI: 10.1371/journal.pone.0090448.
Ghosh, S. P., R. Pathak, P. Kumar, S. Biswas, S. Bhattacharyya, V. P. Kumar, M. Hauer-Jensen and R. Biswas (2016). Gamma-tocotrienol modulates radiation-induced microRNA expression in mouse spleen. Radiation Research.
Gifford, I., W. Vreeland, S. Grdanovska, E. Burgett, J. Kalinich, V. Vergara, C. K. C. Wang, E. Maimon, D. Poster and M. Al-Sheikhly (2014). Liposome-based delivery of a boron-containing cholesteryl ester for high-LET particle-induced damage of prostate cancer cells: A boron neutron capture therapy study. International Journal of Radiation Biology 90(6): 480-485 DOI: 10.3109/09553002.2014.901579.
Gorbunov, N. V., D. P. McDaniel, M. Zhai, P. J. Liao, B. R. Garrison and J. G. Kiang (2015). Autophagy and mitochondrial remodelling in mouse mesenchymal stromal cells challenged with Staphylococcus epidermidis. J Cell Mol Med 19(5): 1133-1150 DOI: 10.1111/jcmm.12518.
Gorbunov N. V. and J. G. Kiang (2017). Ghrelin therapy decreases incidents of intracranial hemorrhage in mice after whole-body ionizing irradiation combined with burn trauma. Int J Mol Sci 18(8). DOI: 10.3390/ijms18081693.
Gulani, J., A. Koch, M. G. Chappell, C. L. Christensen, P. Facemire, V. K. Singh, N. I. Ossetrova, V. Srinivasan and R. K. Holt (2016). "A case report of Cercopithicine herpesvirus 9 (simian varicella virus) infection post [sic] total body irradiation in a rhesus macaque (Macaca mulatta)." Comparative Medicine 66: 150-153.
Gupta, P., M. Gayen, J. T. Smith, V. Y. Matrosova, E. K. Gaidamakova, M. J. Daly, J. G. Kiang and R. K. Maheshwari (2016). MDP: A Deinococcus Mn2+-decapeptide complex protects mice from ionizing radiation. PLOS One
Ha, C. T., X. H. Li, D. D. Fu, M. Moroni, C. Fisher, R. Arnott, V. Srinivasan and M. Xiao (2014). Circulating Interleukin-18 as a biomarker of total-body radiation exposure in mice, minipigs, and nonhuman primates (NHP). PLoS ONE 9(10) DOI: 10.1371/journal.pone.0109249.
Ha, C. T., X. H. Li, D. Fu and M. Xiao (2016). Circulating IL-18 binding protein (IL-18BP) and IL-18 as dual biomarkers of total-body radiation exposure in mice. Radiation Research.
Hu, S. W., W. F. Blakely and F. A. Cucinotta (2015). HEMODOSE: A biodosimetry tool based on multi-type blood cell counts. Health Physics 109(1): 54-68 DOI: 10.1097/hp.0000000000000295.
Huff, L. A., A. O. Olabisi and V. K. Singh (2018). Global health security: Radiation countermeasure for acute radiation syndrome. Journal of Radiation and Cancer Research 9:1-3, DOI: 10.4103/jrcr.jrcr_43_17.
Islam, A., D. L. Bolduc, M. Zhai, S. S. Hobbs and J. M. Swift (2015). 2-0, 3-0 Desulfated heparin does not affect radiation injury induced mortality but reduces radiation combined skin-burn injury induced survival in mice. Journal of Cell Science and Therapy 6: 209. doi:10.4172/2157-7013.1000209.
Islam, A., D. L. Bolduc, M. Zhai, J. G. Kiang and J. M. Swift (2015). Captopril increases survival after whole-body ionizing irradiation but decreases survival when combined with skin-burn trauma in mice. Radiat Res DOI: 10.1667/rr14113.1.
Islam, A., S. Ghimbovschi, M. Zhai and J. M. Swift (2015). An exploration of molecular correlates relevant to radiation combined skin-burn trauma. PLoS ONE 10(8) DOI: 10.1371/journal.pone.0134827.
Iwanoff, C. J., H. Barbier, J. C. Massengill, E. Lombardini, C. L. Christensen, J. L. Buller and D. D. Gruber (2015). Laparoscopic colpotomy using monopolar electrocautery: does power really matter? Female Pelvic Medicine and Reconstructive Surgery 21(3): 141-145 DOI: 10.1097/spv.0000000000000146.
Jacobowitz, D. M., P. C. Liacouras, V. K. Singh, R. J. Ursano, H. B. Pollard and C. L. Dalgard (2015). 3-D Printing of a nonhuman primate brain slicer for accurate, high resolution sampling of specific regions of fresh or frozen brain. Journal of Primatology 4: 125. doi:10.4172/2167-6801.1000125.
Jones, J. W., G. Tudor, A. Bennett, A. M. Farese, M. Moroni, C. Booth, T. J. MacVittie and M. A. Kane (2014). Development and validation of a LC-MS/MS assay for quantitation of plasma citrulline for application to animal models of the acute radiation syndrome across multiple species. Analytical and Bioanalytical Chemistry 406(19): 4663-4675 DOI: 10.1007/s00216-014-7870-0.
Kalinich, J. F. and C. E. Kasper (2014). Do metals that translocate to the brain exacerbate traumatic brain injury? Med Hypotheses 82(5): 558-562 DOI: 10.1016/j.mehy.2014.02.011.
Kalinich, J. F., E. A. Vane, J. A. Centeno, J. M. Gaitens, K. S. Squibb, M. A. McDiarmid and C. E. Kasper (2014). Embedded metal fragments. Annual Review of Nursing Research 32(1): 63-78 DOI: 10.1891/0739-6686.32.63.
Kiang, J. G. and R. Fukumoto (2014). Ciprofloxacin increases survival after ionizing irradiation combined injury: Gamma-H2ax formation, cytokine/chemokine, and red blood cells. Health Physics 106(6): 720-726 DOI: 10.1097/hp.0000000000000108.
Kiang, J. G., B. R. Garrison, J. T. Smith and R. Fukumoto (2014). Ciprofloxacin as a potential radio-sensitizer to tumor cells and a radio-protectant for normal cells: differential effects on gamma-H2AX formation, p53 phosphorylation, Bcl-2 production, and cell death. Molecular and Cellular Biochemistry 393(1-2): 133-143 DOI: 10.1007/s11010-014-2053-z.
Kiang J. G. and N. V. Gorbunov (2014) Bone marrow mesenchymal stem cells increase survival after ionizing irradiation combined with wound trauma: Characterization and therapy. J Cell Sci Ther 5:190 (8 pages). doi: 10.4172/2157-7013.1000190.
Kiang, J. G., M. Zhai, P. J. Liao, D. L. Bolduc, T. B. Elliott and N. V. Gorbunov (2014). Pegylated G-CSF inhibits blood cell depletion, increases platelets, blocks splenomegaly, and improves survival after whole-body ionizing irradiation but not after irradiation combined with burn. Oxidative Medicine and Cellular Longevity DOI: 10.1155/2014/481392.
Kiang, J. G., M. Zhai, P. J. Liao, T. B. Elliott and N. V. Gorbunov (2014). Ghrelin therapy improves survival after whole-body ionizing irradiation or combined with burn or wound: amelioration of leukocytopenia, thrombocytopenia, splenomegaly, and bone marrow injury. Oxidative Medicine and Cellular Longevity DOI: 10.1155/2014/215858.
Kiang, J.G. (2016) Adult mesenchymal stem cells and radiation injury. Health Physics 111: 198-203. doi: 10.1097/HP.0000000000000459.
Kiang, J. G., J. T. Smith, M. N. Anderson, J. M. Swift, C. L. Christensen, P. Gupta, N. Balakathiresan and R. K. Maheshwari (2015). Hemorrhage exacerbates radiation effects on survival, leukocytopenia, thrombopenia, erythropenia, bone marrow cell depletion and hematopoiesis, and inflammation-associated microRNA Expression in Kidney. PLoS ONE 10(9): e0139271 DOI: 10.1371/journal.pone.0139271.
Kiang, J. G. (2017). Exacerbation of mild hypoxia on acute radiation syndrome and subsequent mortality. Adaptive Med 9(1): 28-33. DOI: 10.4247/AM.2017.ABG170.
Kiang, J. G. , M. Zhai, P.-J. Liao, C. Ho, N. V. Gorbunov and T. B. Elliott (2017). Thrombopoietin receptor agonist mitigates hematopoietic acute radiation syndrome and improves survival after whole-body ionizing irradiation followed by wound trauma. Mediators of Imflammation 2017: 7582079. DOI: 10.1155/2017/7582079.
Kiang, J. G. M. Zhai, D. L. Bolduc, J. T. Smith, M. N. Anderson, C. Ho, B. Lin and S. Jiang, (2017). Combined therapy of pegylated-G-CSF and Alx100TPO improves survival and mitigates acute radiation syndrome after whole-body ionizing irradiation alone and followed by wound trauma. Radiat Res 188: 476-490. DOI: 10.1667/RR14647.1.
Kiang, J. G. , J. T. Smith, M. N. Anderson, T. B. Elliott, P. Gupta, N. Balakathiresan, R. K. Maheshwari and B. Knollman-Ritschel (2017). Hemmorrhage enhances cytokine, complement component 3 and caspase-3 and regulates microRNAs assosiated with intestinal damage after whole-body gamma-irradiation in combined injury. Plos ONE 12(9): e0184393. DOI: 10.1371/journal.pone.0184393.
Kiang, J. G., M. N. Anderson and J. T. Smith ( 2018). Ghrelin therapy mitigates bone marrow injury and splenocytopenia by sustaining circulating G-CSF and KC increases after irradiation combined with wound. Cell Biosci 8: 27. DOI: 10.1186/s13578-018-0225-3.
Kiang, J. G. and A. O. Olabisi (2019). Radiation: A poly-traumatic hit leading to multi-organ death. Cell & Bioscience 9:25, DOI: 10.1186/s13578-019-0286-y.
Kiang, J. G., J. T. Smith, M. N. Anderson, M. V. Umali, C. Ho, M. Zhai, B. Lin and S. Jiang (2019). A novel therapy, using Ghrelin with pegylated G-CSF, inhibits brain hemorrhage from ionizing radiation or combined radiation injury. Pharmacy and Pharmacology International Journal 7:133-145, DOI: 10.15406/ppij.2019.07.00243.
Klionsky D. J...J. G. Kiang ...S. M. Zughaler (2016). Guidlines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12(1): 1-222. DOI: 10.1080/15548627.2015.1100356
Koch, A., J. Gulani, G. King, K. Hieber, M. Chappell and N. Ossetrova (2016). Establishment of Early Endpoints in Mouse Total-Body Irradiation Model. PLoS One 11(8): e0161079 DOI: 10.1371/journal.pone.0161079.
Krivokrysenko, V. I., I. Toshkov, A. Gleiberman, P. Krasnov, I. Shyshynova, I. Bespalov, R. Maitra, N. Narizhneva, V. K. Singh, M. H. Whitnall, A. Purmal, A. Shakhov, A. Gudkov and E. Feinstein (2015). The Toll-like receptor agonist Entolimod mitigates acute radiation syndrome in non-human primates. PLoS ONE 10(9):e0135388. doi: 10.1371/journal.pone.0135388.
Li, X. H., C. T. Ha, D. D. Fu, M. R. Landauer, S. P. Ghosh and M. Xiao (2015). Delta-tocotrienol suppresses radiation-induced microRNA-30 and protects mice and human CD34+ Cells from radiation injury. PLoS ONE 10(3) DOI: 10.1371/journal.pone.0122258.
Li, X. H., C. T. Ha and M. Xiao (2016). MicroRNA-30 inhibits antiapoptotic factor Mcl-1 in mouse and human hematopoietic cells after radiation exposure. Apoptosis.
Li, X., W. Cui, L. Hull, J. T. Smith, J. G. Kiang and M. Xiao (2018). Effects of low-to-moderate doses of γ-radiation on mouse hematopoietic system. Radiation Research 190:612-622, DOI: 10.1667/RR15087.1.
Mak, T. D., J. B. Tyburski, K. W. Krausz, J. F. Kalinich, F. J. Gonzalez and J. Fornace, A.J. (2015). Exposure to ionizing radiation reveals global dose- and time-dependent changes in the urinary metabolome of rat. Metabolomics 11: 1082-1094.
McCready, T. (2014). Change to ensure compliance. Lab Animal 43(1): 14-14.
McGann, C., A. Miaullis and N. Page (2015). Radiologists: The unsuspecting subject matter experts. Journal of the American College of Radiology 12(7): 745-753 DOI: 10.1016/j.jacr.2015.01.014.
Menon, S. S., M. Uppal, S. Randhawa, M. S. Cheema, N. Aghdam, R. L. Usala, S. P. Ghosh, A. K. Cheema and A. Dritschilo (2016). Radiation metabolomics: current status and future directions. Frontiers in Oncology 6 DOI: 10.3389/fonc.2016.0020.
Milner, E. E., E. G. Daxon, M. T. Anastasio, J. T. Nesler, R. L. Miller and W. F. Blakely (2016). Concepts of Operations (CONOPS) for biodosimetry tools employed in operational environments. Health Phys 110(4): 370-379 DOI: 10.1097/hp.0000000000000470.
Miura, T., A. Nakata, K. Kasai, M. Nakano, Y. Abe, E. Tsushima, N. I. Ossetrova, M. A. Yoshida and W. F. Blakely (2014). A novel parameter, cell-cycle progression index, for radiation dose absorbed estimation in the premature chromosome condensation assay. Radiat Prot Dosimetry 159(1-4): 52-60 DOI: 10.1093/rpd/ncu126.
Moroni, M., T. B. Elliott, N. E. Deutz, C. H. Olsen, R. Owens, C. Christensen, E. D. Lombardini and M. H. Whitnall (2014). Accelerated hematopoietic syndrome after radiation doses bridging hematopoietic (H-ARS) and gastrointestinal (GI-ARS) acute radiation syndrome: Early hematological changes and systemic inflammatory response syndrome in minipig. International Journal of Radiation Biology 90(5): 363-372 DOI: 10.3109/09553002.2014.892226.
Moroni, M., M. Port, A. Koch, J. Gulani, V. Meineke and M. Abend (2014). Significance of bioindicators to predict survival in irradiated minipigs. Health Physics 106(6): 727-733 DOI: 10.1097/hp.0000000000000109.
Moroni, M., M. Port, J. Gulani, M. Chappell and M. Abend (2015). Significance of bioindicators for early predictions on diagnosis and therapy of irradiated minipigs. Health Physics.
Oestreicher, U., D. Samaga, E. Ainsbury, A. C. Antunes, A. Baeyens, L. Barrios, C. Beinke, P. Beukes, W. F. Blakely, A. Cucu, A. De Amicis, J. Depuydt, S. De Sanctis, M. Di Giorgio, K. Dobos, I. Dominguez, P. N. Duy, M. E. Espinoza, F. N. Flegal, M. Figel, O. Garcia, O. Monteiro Gil, E. Gregoire, C. Guerrero-Carbajal, I. Guclu, V. Hadjidekova, P. Hande, U. Kulka, J. Lemon, C. Lindholm, F. Lista, K. Lumniczky, W. Martinez-Lopez, N. Maznyk, R. Meschini, R. M'Kacher, A. Montoro, J. Moquet, M. Moreno, M. Noditi, J. Pajic, A. Radl, M. Ricoul, H. Romm, L. Roy, L. Sabatier, N. Sebastia, J. Slabbert, S. Sommer, M. Stuck Oliveira, U. Subramanian, Y. Suto, T. Que, A. Testa, G. Terzoudi, A. Vral, R. Wilkins, L. Yanti, D. Zafiropoulos and A. Wojcik (2016). RENEB intercomparisons applying the conventional Dicentric Chromosome Assay (DCA). Int J Radiat Biol: 1-10.
Ossetrova, N. I., D. P. Condliffe, P. H. Ney, K. Krasnopolsky, K. P. Hieber, A. Rahman and D. J. Sandgren (2014). Early-response biomarkers for assessment of radiation exposure in a mouse total-body irradiation model. Health Physics 106(6): 772-786 DOI: 10.1097/hp.0000000000000094.
Ossetrova, N. I., D. J. Sandgren and W. F. Blakely (2014). Protein biomarkers for enhancement of radiation dose and injury assessment in nonhuman primate total-body irradiation model. Radiat Prot Dosimetry 159(1-4): 61-76 DOI: 10.1093/rpd/ncu165.
Ossetrova, N. I., W. F. Blakely, V. Nagy, C. McGann, P. H. Ney, C. L. Christensen, A. L. Koch, J. Gulani, G. B. Sigal, E. N. Glezer and K. P. Hieber (2016). Non-human Primate Total-body Irradiation Model with Limited and Full Medical Supportive Care Including Filgrastim for Biodosimetry and Injury Assessment. Radiat Prot Dosimetry DOI: 10.1093/rpd/ncw176.
Ossetrova, N. I., P. H. Ney, D. P. Condliffe, K. Krasnopolsky and K. P. Hieber (2016). Acute Radiation Syndrome Severity Score System in Mouse Total-Body Irradiation Model. Health Phys 111(2): 134-144 DOI: 10.1097/hp.0000000000000499.
Pang, D. L., J. S. Nico, L. Karam, O. Timofeeva, W. F. Blakely, A. Dritschilo, M. Dizdaroglu and P. Jaruga (2014). Significant disparity in base and sugar damage in DNA resulting from neutron and electron irradiation. Journal of Radiation Research 55(6): 1081-1088 DOI: 10.1093/jrr/rru059.
Pannkuk, E. L., E. C. Laiakis, V. K. Singh and A. J. Fornace Jr. (2017). Lipodomic signatures of nonhuman primates with radiation-induced hematopoietic syndrome. Scientific Reports 7:9777 , DOI: 10.1038/s41598-017-10299-w.
Pannkuk, E. L., E. C. Laiakis, A. J. Fornace Jr, O. O. Fatanmi and V. K. Singh (2018). A metabolomic serum signature from nonhuman primates treated with a radiation countermeasure, gamma-tocotrienol and exposed to ionizing radiation. Health Physics 115:3-11, DOI: 10.1097/HP.0000000000000776.
Pannkuk, E. L., E. C. Laiakis, M. Garcia, A. J. Fornace Jr and V. K. Singh (2018). Nonhuman primates with acute radiation syndrome: Results from a non-targeted serum metabolmics study after 7.2 Gy total body irradiation. Radiation Research 190:576-583, DOI: 10.1667/RR15167.1.
Pathak, R., S. A. Pawar, Q. Fu, P. K. Gupta, M. Berbee, S. Garg, V. Sridharan, W. Z. Wang, P. G. Biju, K. J. Krager, M. Boerma, S. P. Ghosh, A. K. Cheema, H. P. Hendrickson, N. Aykin-Burns and M. Hauer-Jensen (2014). Characterization of transgenic Gfrp knock-in mice: implications for tetrahydrobiopterin in modulation of normal tissue radiation responses. Antioxidants & Redox Signaling 20(9): 1436-1446 DOI: 10.1089/ars.2012.5025.
Pathak, R. and P. G. S. Prasanna (2014). Premature chromosome condensation in human resting peripheral blood lymphocytes without mitogen stimulation for chromosome aberration analysis using specific whole chromosome DNA hybridization probes. Molecular Toxicology Protocols, 2nd Edition. P. Keohavong and S. G. Grant. 1105: 171-181. DOI: 10.1007/978-1-62703-739-6_14.
Pathak, R., L. J. Shao, S. P. Ghosh, D. H. Zhou, M. Boerma, H. Weiler and M. Hauer-Jensen (2015). Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice. PLoS ONE 10(4) DOI: 10.1371/journal.pone.0122511.
Pathak, R., A. Bachri, S. P. Ghosh, I. Koturbash, M. Boerma, R. K. Binz, J. R. Sawyer and M. Hauer-Jensen (2016). The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage. Pharm Res DOI: 10.1007/s11095-016-1950-0.
Pathak, R., S. P. Ghosh, D. Zhou and M. Hauer-Jensen (2016). The Vitamin E Analog Gamma-Tocotrienol (GT3) and Statins Synergistically Up-Regulate Endothelial Thrombomodulin (TM). Int J Mol Sci 17(11).
Ramakumar, A., U. Subramanian and P. G. S. Prasanna (2015). High-throughput sample processing and sample management; the functional evolution of classical cytogenetic assay towards automation. Mutation Research: Genetic Toxicology and Environmental Mutagenesis DOI: 10.1016/j.mrgentox.2015.07.011.
Rosen, E. M., R. Day and V. K. Singh (2014). New approaches to radiation protection. Front Oncol 4: 381.
Seed, T. M., C. E. Inal and V. K. Singh (2014). Radioprotection of hematopoietic progenitors by low dose amifostine prophylaxis. International Journal of Radiation Biology 90(7): 594-604 DOI: 10.3109/09553002.2014.899450.
Seed, T. M., V. K. Singh, B. K. Hanlon (2019): Early and late changes in radiation-induced gene expression arrays following radioprotection with amifostine. Journal of Radiation and Cancer Research 10:44-57, DOI: 10.4103/jrcr.jrcr_5_19.
Singh, V. K., S. Y. Wise, O. O. Fatanmi, L. A. Beattie, E. J. Ducey and T. M. Seed (2014). Alpha-tocopherol succinate- and AMD3100-mobilized progenitors mitigate radiation combined injury in mice. Journal of Radiation Research 55(1): 41-53 DOI: 10.1093/jrr/rrt088.
Singh, V. K., S. Y. Wise, O. O. Fatanmi, L. A. Beattie and T. M. Seed (2014). Preclinical development of a bridging therapy for radiation casualties: appropriate for high risk personnel. Health Physics 106(6): 689-698 DOI: 10.1097/hp.0000000000000089.
Singh, V. K., S. Y. Wise, O. O. Fatanmi, J. Scott, P. L. P. Romaine, V. L. Newman, A. Verma, T. B. Elliott and T. M. Seed (2014). Progenitors mobilized by gamma-tocotrienol as an effective radiation countermeasure. PLoS ONE 9(11) DOI: 10.1371/journal.pone.0114078.
Singh, V. K., S. Y. Wise, J. R. Scott, P. L. P. Romaine, V. L. Newman and O. O. Fatanmi (2014). Radioprotective efficacy of delta-tocotrienol, a vitamin E isoform, is mediated through granulocyte colony-stimulating factor. Life Sci 98(2): 113-122 DOI: 10.1016/j.lfs.2014.01.065.
Singh, V. K., P. L. P. Romaine, V. L. Newman and T. M. Seed (2014). Tocols induce G-CSF and mobilise progenitors that mitigate radiation injury. Radiat Prot Dosimetry 162(1-2): 83-87 DOI: 10.1093/rpd/ncu223.
Singh, V. K., V. L. Newman, P. L. P. Romaine, S. Y. Wise and T. M. Seed (2014). Radiation countermeasure agents: an update (2011-2014). Expert Opin Ther Pat 24(11): 1229-1255 DOI: 10.1517/13543776.2014.964684.
Singh, V. K., V. L. Newman, A. N. Berg and T. J. MacVittie (2015). Animal models for acute radiation syndrome drug discovery. Expert Opin Drug Discov 10(5): 497-517 DOI: 10.1517/17460441.2015.1023290.
Singh, V. K., V. L. Newman and T. M. Seed (2015). Colony-stimulating factors for the treatment of the hematopoietic component of the acute radiation syndrome (H-ARS): A review. Cytokine 71(1): 22-37 DOI: 10.1016/j.cyto.2014.08.003.
Singh, V. K. and H. B. Pollard (2015). Patents for Toll-like receptor ligands as radiation countermeasures for acute radiation syndrome. Expert Opin Ther Pat: 25(10):1085-92. doi: 10.1517/13543776.2015.1064900.
Singh, V. K., P. L. P. Romaine and V. L. Newman (2015). Biologics as countermeasures for acute radiation syndrome: where are we now? Expert Opin Biol Ther 15(4): 465-471 DOI: 10.1517/14712598.2015.986453.
Singh, V. K., P. L. P. Romaine and T. M. Seed (2015). Medical countermeasures for radiation exposure and related injuries: characterization of medicines, FDA-approval status and inclusion into the strategic national stockpile. Health Physics 108(6): 607-630 DOI: 10.1097/hp.0000000000000279.
Singh, V. K., O. O. Fantanmi, A. Verma, V. L. Newman, S. Y. Wise, P. L. P. Romaine and A. N. Berg (2016). Progenitor cell mobilization by gamma-tocotrienol, a promising radiation countermeasure. Health Physics 111: 85-92.
Singh, V. K., O. O. Fatanmi, S. Y. Wise, V. L. Newman, P. L. P. Romaine and T. M. Seed (2016). The potentiation of the radioprotective efficacy of two medical countermeasures, gamma-tocotrienol and amifostine, by a combination prophylactic modality. Radiation Protection Dosimetry DOI 10.1093/rpd/ncw223.
Singh, V. K., M. Garcia, S. Y. Wise and T. M. Seed (2016). Medical countermeasures for unwanted CBRN exposures: Part I. Chemical and biological threats with review of recent countermeasure patents. Expert Opinion on Therapeutic Patents 26:1431-1447.
Singh, V. K. and M. Hauer Jensen (2016). Gamma-tocotrienol as a promising countermeasure for acute radiation syndrome: current status. International Journal of Molecular Sciences 17: e663 (20 pp).
Singh, V. K., V. L. Newman, P. L. P. Romaine, M. Hauer-Jensen and H. B. Pollard (2016). Use of biomarkers for assessing radiation injury and efficacy of countermeasures. Expert Review of Molecular Diagnostics 16: 65-81 DOI: DOI: 10.1586/14737159.2016.1121102.
Singh, V. K., S. Kulkarni, O. O. Fatanmi, S. Y. Wise, V. L. Newman, P. L. P. Romaine, H. Hendrickson, J. Gulani, S. P. Ghosh, K. S. Kumar and M. Hauer-Jensen (2016). Radioprotective efficacy of gamma-tocotrienol in nonhuman primates. Radiation Research 185: 285-298.
Singh, V. K., P. L. P. Romaine, V. L. Newman and T. M. Seed (2016). Medical countermeasures for unwanted CBRN exposures: Part II. Radiological and nuclear threats with review of recent countermeasure patents. Expert Opinion on Therapeutic Patents 26: 1399-1408.
Singh, V. K., K. D. Thrall and M. Hauer-Jensen (2016). Minipigs as models in drug discovery. Expert Opin Drug Discov 11:1131-1134, DOI: 10.1080/17460441.2016.1223039.
Singh, V. K. and A. O. Olabisi (2017). Nonhuman primates as models for the discovery and development of radiation countermeasures. Expert opinion on drug discovery 12:695-709, DOI: 10.1080/17460441.2017.1323863.
Singh, V. K. and T. M. Seed (2017). A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: Part Ι. Radiation sub-syndromes, animal models and FDA-approved countermeasures. International Journal of Radiation Biology 93: 851-869, DOI: 10.1080/17460441.2017.1323863.
Singh, V. K., M. Garcia and T. M. Seed (2017). A review of radiation countermeaures focusing on injury-specific medicinals and regulatory approval status: part ΙΙ. Countermeasures for limited indications, internalized radionuclides, emisis, late effects and agents demonstrating efficacy in large animals with or without FDA IND status. International Journal of Radiation Biology 93:870-884, DOI: 10.1080/09553002.2017 . 1338782.
Singh, V. K., B. K. Hanlon, P. T. Santiago and T. M. Seed (2017) . A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: Part ΙΙΙ. Countermeasures under early stages of development along with 'standard of care' medicinal and procedures not requiring regulatory approval for use. International Journal of Radiation Biology 93: 885-906, DOI: 10.1080/09553002.2017.1332440.
Singh, V. K. and H. B. Pollard (2017). Ionizing radiation-induced altered microRNA expression as biomarkers for assessing acute radiation injury. Expert Review of Molecular Diagnostics 17:871-874, DOI: 10.1080/17460441.2017.1323863.
Singh, V. K., O. O. Fatanmi, P. T. Santiago, M Simas, B. K. Hanlon, M. Garcia and S. Y. Wise (2018). Current status of radiation countermeasures for acute radiation syndrome under advanced development. Journal of Radiation and Cancer Research 9: 13-27, DOI: 10.4103/jrcr_3_18.
Singh, V. K., P. T. Santiago and T. J. MacVittie (2018). Opportunities and challenges with animal models for acute radiation syndrome drug discovery. Expert Opinion on Drug Discovery 13:987-992, DOI: 10.1080/1740441.2018.1526172.
Singh, V. K., M. Simas and H. Pollard (2018). Biomarkers for acute radiation syndrome: Challenges for devloping radiation countermeasures following Animal Rule. Expert Review of Molecular Diagnostics 18:921-924, DOI: 10.1080/14737159.2018.1533404.
Singh, V. K. and T. M. Seed (2018). An update on sargramostim for treatment of acute radiation syndrome. Drugs of Today 54:679-693, DOI: 10.1358/dot.2018.54.11.2899370.
Singh, V.K., T. M. Seed, A. O. Olabisi (2019): Drug design strategies for acute radiation syndrome. Expert Opinion on Drug Discovery 14:701-715, DOI: org/10.1080/17460441.2019.1604674.
Singh, V. K., P. T. Santiago, M. Simas, M. Garcia, O. O. Fatanmi, S. Y. Wise, T. M. Seed (2018). Acute radiation syndrome: Biomarkers for radiation injury. Journal of Radiation and Cancer Research 9:132-146,DOI: 10.4103/jrcr.jrcr_26_18.
Singh, V. K., T. M. Seed (2019). The efficacy and safety of amifostine for the acute radiation. Expert Opinion on Drug Safety 18:1077-1090, 2019. DOI: 0.1080/14740338.2019.1666104
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