Announcements

Center for Neuroscience and Regenerative Medicine

Announcements

FUNDING PRE-ANNOUNCEMENT

Due to the current Continuing Resolution, the FY17 Defense Appropriations bill has not been passed. Although funds have not been appropriated for the Department of Defense Psychological Health/Traumatic Brain Injury Research Program (PH/TBIRP), the PH/TBIRP is providing the information in this pre-announcement to allow investigators time to plan and develop ideas for submission to the anticipated FY17 funding opportunities.

FY17 PH/TBIRP Program Announcements and General Application Instructions for the following award mechanisms being released on behalf of the Joint Program Committee 8/Clinical and Rehabilitative Medicine Research Program are anticipated to be posted on Grants.gov in March 2017. Pre-application and application deadlines will be available when the Program Announcements are released. This pre-announcement should not be construed as an obligation by the Government, and funding of research projects received in response to these Program Announcements is contingent on the availability of Federal funds appropriated for the PH/TBIRP.

As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency’s J9 Research and Development Directorate manages the Defense Health Program’s Research, Development, Test, and Evaluation appropriation. The managing agent for the anticipated Program Announcements/Funding Opportunities is the U.S. Army Medical Research and Materiel Command Congressionally Directed Medical Research Programs (CDMRP).

FY17 Complex Traumatic Brain Injury (TBI) Rehabilitation Research Focus Areas. The FY17 PH/TBIRP will solicit research applications for the following focus areas:

  1. Develop, evaluate, and/or validate Return to Duty outcomes following rehabilitation in patients with TBI. Develop ecologically valid (e.g., military-specific tasks) and clinically practical standardized functional outcome measures for Service Members with TBI that inform return to duty/participation. Outcome measures should address the impact on function- and participation-level performance of specific cognitive deficits (e.g., processing, attention, memory) and/or sensorimotor dysfunction.
  2. Develop and/or evaluate treatment strategies (e.g., multitask/dual-task, sequential vs. parallel, etc.) for TBI sequela including, but not limited to, pain, cognitive deficits (attention, memory, etc.), exertion-induced symptoms, and dizziness. Intervention strategies should aim to increase patient tolerance for rehabilitation and result in measurable improvement in targeted impairments and function- and participation-level performance.
  3. Evaluate the effectiveness of clinically feasible rehabilitation technologies for the objective assessment and/or treatment of cognitive deficits and/or sensory or sensorimotor dysfunction in Service members with TBI with the intent to inform return to duty/participation decisions.
  4. For patients with TBI-associated cognitive deficits or sensory or sensorimotor dysfunction(s):
    1. Investigate the delivery of rehabilitation interventions with regard to optimization of treatment prescription (i.e., frequency, intensity, timing, and type).
    2. Investigate the comparative effectiveness of interventions resulting in measurable improvement in targeted impairment and functional- and participation-level performance.
  5. Understand the neural mechanisms of recovery and/or natural progression following isolated or cumulative TBIs in Service Members. Investigators should explore one of the following:
    1. Cognitive Deficits – to inform novel rehabilitation interventions that drive neuroplasticity and lead to the recovery of cognitive function.
    2. Sensory or Sensorimotor Dysfunction – to inform novel rehabilitation interventions that lead to recovery of sensory or sensorimotor function.
    3. Chronification of Pain – to inform knowledge of and treatment for the progression from acute to chronic pain in TBI-associated headache/migraine.

FUNDING ANNOUNCEMENT

Joint Program Committee 6 Combat Casualty Care Research Program

Precision Trauma Care Research Award

Synopsis:  The intent of the Precision Trauma Care Research Award (PTCRA) is to support research applying precision medicine concepts to trauma care. In order to improve the care of combat casualties, the JPC-6/CCCRP requires capabilities to more accurately diagnose and treat injuries.  In general, the field of trauma care progresses as empirical evidence accumulates.  This empirical evidence supports reduction of unwarranted practice variability which leads to refinenment of protocols through improved diagnostic and prognostic indicators that account for patient-specific variables such as injury pattern, co-morbidities,  and demographics, as examples.  Further refinement occurs through incorporation of near-term patient-specific variables such as injury progression and response to therapies.The result is a precision medicine approach for trauma care that drives application of interventions to improve outcomes following trauma.  

JPC-6/CCCRP seeks to develop precision medicine approaches for trauma care in austere environments ( for example point of injury care on the battlefield, far forward surgical teams, combat support hospitals). New solutions are also required that will support medical providers in the assessment, diagnosis, and treatment of military trauma in out of hospital settings with limited resources through Role 4, supporting the continuum of trauma care.  Proposed research should consider this continuum of trauma care and must be focused on enabling  patient-specific interventions and improved outcomes rather than "one size fits all" population-based tools and techniques.

Four focus areas for this award have been identified:

Neurotrauma

Focus Area 1:  Improving the characterization of TBI

Focus Area 2:  Understanding the factors that influence and/or inform patient responsiveness to TBI therapeutic interventions

Forward Surgical, En Route, and Critical Care

Focus Area 3:  Understanding the role of environmental and physiological factors impacting injury outcomes

Focus Area 4:  Developing materiel and knowledg products to assist medical and non-medical care providers in administering individualized combat-related or trauma-induced injury care

Submission and Review Dates and Times

Pre-application Submission Deadline:  5:00 p.m. ET, March 17, 2017

Invitation to Submit an Application:  April 25, 2017

Application Submission Deadline:  11:59 p.m. ET, June 15, 2017

Peer Review:  August 2017

Programmatic Review:  September 2017

NOTE:  There is an extramural and an intramural submission process.

For the complete program announcement and associated application materials, click here.