Clinical Funded Projects

Clinical Funded Projects

We have leveraged funding to solicit competitive research proposals in support of our scientific mission. These resources and expertise come together to support the overarching goal of an integrated research program in which preclinical and clinical investigators interact closely, and continuously learn from each other to accelerate research and translation to patient care.
We solicit funding opportunity announcements to: 
  1. Address the full spectrum of traumatic brain injury (TBI) with special emphasis on militarily relevant forms of TBI and the concurrent development of post-traumatic stress
  2. Exhibit high scientific merit based on potential innovation and impact on the field
  3. Advance and accelerate TBI research to improve recovery of the Warfighter through:
    • fostering collaborative efforts across CNRM investigators
    • leveraging CNRM resources
    • enabling synergistic efforts with other Military Health System (MHS) activities

Below are summaries of our active clinical CNRM funded projects. 

Active Clinical Funded Projects 

Development of Bench and Preclinical MRI Methods to Assess Glymphatic Clearance in the Living Brain
Principal Investigator: Peter Basser, Ph.D.
Aim: To develop a family of novel non-invasive in vivo dispersion MRI methods to characterize cerebrospinal fluid transport within each brain voxel. These approaches will be used to characterize the efficacy of brain fluid mixing.
Keywords: MRI; in vivo; optimization; dispersion; microscopy

Imaging [18F] AV1451 and [18F] AV45 in Military Service Members with Blast-related Mild Traumatic Brain Injury
Principal Investigators: Dara Dickstein, PhD; Grant Bonavia, MD, PhD 
Aim: To assess the brain pathology associated with blast exposure by:
  • Performing two different positron-emission tomography (PET) scans to identify tau deposits and amyloid-beta deposits in Service Members with a history of blast exposure and mild TBI
  • Conducting additional imaging techniques and behavioral tests are used to assess behavioral and memory functions
ClinicalTrials.Gov Link: N/A
Study Flyer: N/A

Improving Sleep Using Bright Light Therapy
Principal Investigators: Jessica Gill, PhD, RN, FAAN; Miranda Lim, MD, PhD 
Aims: 1). Explore the efficacy of morning bright light therapy (MBLT) in veterans with TBI-related sleep disturbances, 2). Determine if MBLT effects cognition, and 3). Identify specific biomarkers indicative of TBI-related sleep disturbances.
Research Locations: Oregon Health and Sciences University and the VA Portland Health Care System; however, this study is also able to be conducted remotely

Investigating the Biological Mechanisms of Alpha-delta Sleep
Principal Investigators: David Brody, MD, PhD; Jackie Gottshall, PhD; John "Kent" Werner, MD, PhD (mentor)
Aim: Alpha-delta sleep is a poorly understood electroencephalogram sleep pathology that has been broadly associated with non-restorative sleep. Characterize the prevalence and epidemiology of alpha-delta sleep following a traumatic brain injury; evaluate the relationship alpha-delta sleep has with slow wave sleep and wakeful cognitive performance. 
Keywords: Alpha-delta sleep, slow wave sleep, cognition, emotional regulation, fMRI, EEG, 

Noninvasive Detection and Localization of Cortical Spreading Depolarizations
Principal Investigators: David Brody, MD, PhD; Mihika Gangolli, PhD; Dzung Pham, PhD (mentor
Aim: Develop and test a diffusion magnetic resonance imaging (MRI) methodology that can noninvasively monitor cortical spreading depolarizations (e.g. changes that take place in the brain during migraine auras). 
Keywords: Migraine, MRI, imaging biomarkers of TBI, cellular swelling 

Reconsolidation of Traumatic Memories to Resolve Post-traumatic Stress Disorder
Principal Investigator: Michael Roy, MD, MPH, COL (Ret)
Aim: To evaluate the effectiveness of Reconsolidation of Traumatic Memories in reducing post-traumatic stress disorder symptom severity in active duty or retired service members.
Location: Walter Reed National Military Medical Center; however, this study is also able to be conducted remotely