Clinical Funded Projects

Clinical Funded Projects

CNRM has leveraged funding to solicit competitive research proposals in support of our scientific mission. These resources and expertise come together to support the overarching goal of an integrated research program in which preclinical and clinical investigators interact closely, and continuously learn from each other to accelerate research and translation to patient care.
 
We solicit funding opportunity announcements to: 
  1. Address the full spectrum of traumatic brain injury (TBI) with special emphasis on militarily relevant forms of TBI and the concurrent development of post-traumatic stress
  2. Exhibit high scientific merit based on potential innovation and impact on the field
  3. Advance and accelerate TBI research to improve recovery of the Warfighter through:
    • fostering collaborative efforts across CNRM investigators
    • leveraging CNRM resources
    • enabling synergistic efforts with other Military Health System (MHS) activities

Below are summaries of all our active or recently completed clincal CNRM funded projects. 

Active Clinical Funded Projects
Principal Investigator: John Butman, M.D., Ph.D.
Aims: To develop advanced magnetic resonance imaging (MRI) acquisition and post-processing techniques for improved mapping and analysis of TBI-related microhemorrhages.
  • Evaluate and optimize accelerated Susceptibility Weighted Imaging (SWI) and Quantitative Susceptibility Mapping (QSM) acquisition techniques
  • Develop algorithms and software from T2*-weighted MRI that can automatically detect microhemorrhages; characterize their size and shape; and map their spatial distribution
Keywords: SWI; QSM; microhemorrhage
 
 
Principal Investigator: Peter Basser, Ph.D.
Aim: To develop a family of novel non-invasive in vivo dispersion MRI methods to characterize cerebrospinal fluid transport within each brain voxel. These approaches will be used to characterize the efficacy of brain fluid mixing.
Keywords: MRI; in vivo; optimization; dispersion; microscopy
 
 
Principal Investigator: Diane Damiano, M.D.
Aim: Examine the effect two exercise programs have on cognitive performance, physical functioning, and health-related quality of life in patients with chronic TBI.
Keywords: aerobic exercise training; balance; TBI
Publication Link: There are no publications related to this project at this time
 

 
Name: Evaluating Peripheral Exosomes and their Cargo Longitudinally after Traumatic Brain Injury in Civilians and Military
Principal Investigator: Jessica Gill, Ph.D., R.N.
Aim: Using data collected from previous longitudinal TBI studies in civilians and military personnel, explore if changes in neuronal-derived exosomes correlate with TBI recovery outcomes. 
Keywords: neuronal-origin exosomes; cargo biomarkers; neuronal integrity; TBI
Publication Link: There are no publications related to this project at this time
 

 
Principal Investigator: David Brody, M.D., Ph.D.
Aim: To evaluate whether individualized connectome-targeted repetitive transcranial magnetic stimulation (rTMS) is more effective at reducing depression severity in U.S. military personnel with TBI than traditional rTMS methods. 
Keywords: individualized connectome brain mapping; rTMS; mild TBI; depression
Publication Link: There are no publications related to this project at this time
 

 
 Name: Intracranial Visualization Access Device (Modeling and Development)
Principal Investigator: David Brody, M.D., Ph.D.
Aim: Work with the Johns Hopkins University Applied Physics Laboratory to develop a device that can:
  • Detect and localize intracranial hemorrhages
  • Provide intracranial access (e.g., epidural and subdural) for relevant diagnostic and management tools or treatments
Keywords: traumatic epidural hemorrhage; traumatic subdural hemorrhage; intracranial access
Publication Link: There are no publications related to this project at this time
 

 
Name: Imaging [18F] AV1451 and [18F] AV45 in Military Service Members with Blast-related Mild Traumatic Brain Injury
Principal Investigator: Dara Dickstein, Ph.D.
Aim: To assess the brain pathology associated with blast exposure by:
  • Performing two different positron-emission tomography (PET) scans to identify tau deposits and amyloid-beta deposits in Service Members with a history of blast exposure and mild TBI
  • Conducting additional imaging techniques and behavioral tests are used to assess behavioral and memory functions
Keywords: tau; amyloid-beta; PET; structural MRI; functional MRI; blast exposure; TBI
Publication Link: There are no publications related to this project at this time
 

 
Name: Improving sleep in Veterans with Traumatic Brain Injury: Integrating Bright Light Therapy and Blood-based Brain Biomarkers
Principal Investigator: Jessica Gill, Ph.D., R.N.
Aim:
  • Explore the efficacy of morning bright light therapy (MBLT) in veterans with TBI-related sleep disturbances
  • Determine if MBLT effects cognition
  • Identify specific biomarkers indicative of TBI-related sleep disturbances
Keywords: bright light therapy; cognition; insomnia; TBI; blood-based biomarkers
Publication Link: There are no publications related to this project at this time
 

 
Principal Investigator: Michael Roy, M.D., MPH
Aim: To evaluate the effectiveness of Reconsolidation of Traumatic Memories in reducing post-traumatic stress (PTS) symptom severity.
Keywords: TBI; PTS; blood-based biomarkers; cognitive function
Publication Link: There are no publications related to this project at this time
 
 
Principal Investigator: Eric Wassermann, M.D.
Aim: To evaluate the effectiveness of functional magnetic resonance imaging (fMRI) and repetitive transcranial magnetic stimulation (rTMS) in restoring connectivity to damaged pathways.
Keywords: fMRI; rTMS; memory; cognition; hippocampus
Publication Link: There are no publications related to this project at this time
 
 
Principal Investigator: Lawrence Latour, Ph.D.
Aim: To demonstrate whether 18F-Florbetapir, a commercially available positron-emission tomography (PET) tracer, can detect amyloid-beta deposits. Secondary goals include:
  • Exploring the possible correlation between the degree of cerebral amyloid-PET radiotracer uptake and TBI severity
  • Evaluating the spatial distribution of amyloid-beta deposition to the localization of the traumatic lesion
Keywords: acute studies; PET; amyloid-beta; TBI; MRI
Publication Link: There are no publications related to this project at this time