Clinical Research Publications

Clinical Publications

2020 Clinical Study Publications


Dickstein, D. L., De Gasperi, R., Gama Sosa, M., & Perez-Garcia, G . . . Kutsen, A., Pham, D.L., Shahim, P.P., et al.  (2020). Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposureMolecular Psychiatry . doi: 10.1038/s41380-020-0674-z

Iacono, D., Lee, P., Edlow, B. L., Gray, N., Fischl, B., Kenney, K., … Perl, D. P. (2020). Early-Onset Dementia in War Veterans: Brain Polypathology and Clinicopathologic Complexity. Journal of Neuropathology & Experimental Neurology, 79(2), 144–162. doi: 10.1093/jnen/nlz122

Kleij, L. A. V. D., Vis, J. B. D., Restivo, M. C., Turtzo, L. C., Hendrikse, J., & Latour, L. L. (2020). Subarachnoid Hemorrhage and Cerebral Perfusion Are Associated with Brain Volume Decrease in a Cohort of Predominantly Mild Traumatic Brain Injury PatientsJournal of Neurotrauma37(4), 600–607. doi: 10.1089/neu.2019.6514

Lippa, S. M., French, L. M., Bell, R. S., Brickell, T. A., & Lange, R. T. (2020). United States Military Service Members Demonstrate Substantial and Heterogeneous Long-Term Neuropsychological Dysfunction after Moderate, Severe, and Penetrating Traumatic Brain InjuryJournal of Neurotrauma37(4), 608–617. doi: 10.1089/neu.2019.6696

Sandrini, M., Xu, B., Volochayev, R., Awosika, O., Wang, W.-T., Butman, J. A., & Cohen, L. G. (2020). Transcranial Direct Current Stimulation Facilitates Response Inhibition Through Dynamic Modulation of the Fronto-basal Ganglia Network(link is external)Brain Stimulation, 13(1), 96–104. doi:10.1016/j.brs.2019.08.004


Pattinson, C. L., Guedes, V. A., Edwards, K., Mithani, S., Yun, S., Taylor, P., Dunbar, K., Roy, M.J ... Gill, J. M. (2020). Excessive Daytime Sleepiness is Associated with Altered Gene Expression in Military Personnel and Veterans with Posttraumatic Stress Disorder: An RNA Sequencing StudySleep. doi: 10.1093/sleep/zsaa036

Rizk, T., Turtzo, C. L., Cota, M., Van Der Merwe, A. J., Latour, L., Whiting, M. D., & Chan, L. (2020). Traumatic Microbleeds Persist for up to Five Years Following Traumatic Brain Injury Despite Resolution of Other Acute Findings on MRI. Brain Injury. doi: 10.1080/02699052.2020.1725835


Gimbel, S. I., Ettenhofer, M. L., Cordero, E., Roy, M., & Chan, L. (2020). Brain Bases of Recovery Following Cognitive Rehabilitation for Traumatic Brain Injury: a Preliminary StudyBrain Imaging and Behavior. doi: 10.1007/s11682-020-00269-8

Lange, R. T., Lippa, S. M., Bailie, J. M., Wright, M., Driscoll, A., Sullivan, J., … Brickell, T. A. (2020). Longitudinal trajectories and risk factors for persistent postconcussion symptom reporting following uncomplicated mild traumatic brain injury in U.S. military service members. The Clinical Neuropsychologist, 1–22. doi: 10.1080/13854046.2020.1746832

Tschiffely, A. E., Statz, J. K., Edwards, K. A., Goforth, C., Ahlers, S. T., Carr, W. S., & Gill, J. M. (2020). Assessing a Blast-Related Biomarker in an Operational Community: Glial Fibrillary Acidic Protein in Experienced BreachersJournal of Neurotrauma. doi:10.1089/neu.2019.6512


Guedes, V. A., Kenney, K., Shahim, P., Qu, B. X., Lai, C., Devoto, C., Walker, W. C., Nolen, T., Diaz-Arrastia, R., Gill, J. M., & CENC Multisite Observational Study Investigators (2020). Exosomal neurofilament light: A prognostic biomarker for remote symptoms after mild traumatic brain injury?. Neurology, 10.1212/WNL.0000000000009577.

Rodney, T., Taylor, P., Dunbar, K., Perrin, N., Lai, C., Roy, M., & Gill, J. (2020). High IL-6 in Military Personnel Relates to Multiple Traumatic Brain Injuries and Post-Traumatic Stress DisorderBehavioural Brain Research, 112715. 10.1016/j.bbr.2020.112715

Sauerbeck, A. D., Gangolli, M., Reitz, S. J., Salyards, M. H., Kim, S. H., Hemingway, C., Gratuze, M., Makkapati, T., Kerschensteiner, M., Holtzman, D. M., Brody, D. L., & Kummer, T. T. (2020). SEQUIN Multiscale Imaging of Mammalian Central Synapses Reveals Loss of Synaptic Connectivity Resulting from Diffuse Traumatic Brain InjuryNeuron, S0896-6273(20)30281-6


Edwards, K. A., Pattinson, C. L., Guedes, V. A., Peyer, J., Moore, C., Davis, T., Devoto, C., Turtzo, L. C., Latour, L., & Gill, J. M. (2020). Inflammatory Cytokines Associate With Neuroimaging After Acute Mild Traumatic Brain Injury. Frontiers in neurology11, 348.


Davis, T. S., Nathan, J. E., Tinoco Martinez, A. S., De Vis, J. B., Turtzo, L. C., & Latour, L. L. (2020). Comparison of T1-Post and FLAIR-Post MRI for identification of traumatic meningeal enhancement in traumatic brain injury patientsPloS one15(7), e0234881.

Koerte, I. K., Esopenko, C., Hinds, S. R., 2nd, Shenton, M. E., Bonke, E. M., Bazarian, J. J., Bickart, K. C., Bigler, E. D., Bouix, S., Buckley, T. A., Choe, M. C., Echlin, P. S., Gill, J., Giza, C. C., Hayes, J., Hodges, C. B., Irimia, A., Johnson, P. K., Kenney, K., Levin, H. S., … Baron, D. (2020). The ENIGMA sports injury working group:- an international collaboration to further our understanding of sport-related brain injuryBrain imaging and behavior, 10.1007/s11682-020-00370-y.

Kuchinsky, S. E., Eitel, M. M., Lange, R. T., French, L. M., Brickell, T. A., Lippa, S. M., & Brungart, D. S. (2020). Objective and Subjective Auditory Effects of Traumatic Brain Injury and Blast Exposure in Service Members and VeteransFrontiers in Neurology11, 613.

Shahim, P., Politis, A., van der Merwe, A., Moore, B., Chou, Y. Y., Pham, D. L., Butman, J. A., Diaz-Arrastia, R., Gill, J. M., Brody, D. L., Zetterberg, H., Blennow, K., & Chan, L. (2020). Neurofilament Light as a Biomarker in Traumatic Brain InjuryNeurology, 10.1212/WNL.0000000000009983. Advance online publication.

Shahim, P., Politis, A., van der Merwe, A., Moore, B., Ekanayake, V., Lippa, S., Chou, Y. Y., Pham, D. L., Butman, J. A., Diaz-Arrastia, R., Zetterberg, H., Blennow, K., Gill, J. M., Brody, D. L., & Chan, L. (2020). Time course and diagnostic utility of NfL, tau, GFAp, and UCH-L1 in subacute and chronic TBINeurology, 10.1212/WNL.0000000000009985.


Benjamini, D., Hutchinson, E. B., Komlosh, M. E., Comrie, C. J., Schwerin, S. C., Zhang, G., Pierpaoli, C., & Basser, P. J. (2020). Direct and Specific Assessment of Axonal Injury and Spinal Cord Microenvironments Using Diffusion Correlation Imaging. NeuroImage, 221, 117195.

Domenichiello, A. F., Jensen, J. R., Zamora, D., Horowitz, M., Yuan, Z. X., Faurot, K., Mann, J. D., Mannes, A. J., & Ramsden, C. E. (2020). Identifying oxidized lipid mediators as prognostic biomarkers of chronic post-traumatic headachePain, 10.1097/j.pain.0000000000001983.

Dufour, S. C., Adams, R. S., Brody, D. L., Puente, A. N., & Gray, J. C. (2020). Prevalence and Correlates of Concussion in Children: Data from the Adolescent Brain Cognitive Development StudyCortex; a journal devoted to the study of the nervous system and behavior, S0010-9452(20)30275-6.

Edwards, K. A., Leete, J. J., Tschiffely, A. E., Moore, C. Y., Dell, K. C., Statz, J. K., Carr, W., Walker, P. B., LoPresti, M. L., Ahlers, S. T., Yarnell, A. M., & Gill, J. (2020). Blast Exposure Results in Tau and Neurofilament Light Chain Changes in Peripheral BloodBrain Injury34(9), 1213–1221.

Joseph, A. C., Lippa, S. M., Moore, B., Bagri, M., Row, J., Chan, L., & Zampieri, C. (2020). Relating self-reported balance complaints to sensory organization and dual-tasking in chronic traumatic brain injuryPM & R : the journal of injury, function, and rehabilitation, 10.1002/pmrj.12478.

Lange, R.T., Lippa, S.M., Bailie, J.M., Wright, M., Driscoll, A., Sullivan, J., ... Brickell, T.A. (2020). Longitudnal Trajectories and Risk Factors for Persistent Postconcussion Symptom Reporting Following Uncomplicated Mild Traumatic Brain Injury in U.S. Military Service MembersThe Clinical Neuropsychologist, 1-22. doi:10.1080/13854046.2020.1746832.  

Pattinson CL, Meier TB, Guedes VA, et al. (2020). Plasma Biomarker Concentrations Associated With Return to Sport Following Sport-Related Concussion in Collegiate Athletes—A Concussion Assessment, Research, and Education (CARE) Consortium StudyJAMA Network Open, 3(8):e2013191. doi:10.1001/jamanetworkopen.2020.13191


Knutsen, A., Gomez, A., Gangolli, M., Wang, W., Chan, D., Lu, Y., . . . Butman, J., Pham, D. (2020). In vivo estimates of axonal stretch and 3D brain deformation during mild head impact. Brain Multiphysics. In press.

Lippa, S. M., Werner, J. K., Miller, M. C., Gill, J. M., Diaz-Arrastia, R., & Kenney, K. (2020). Recent Advances in Blood-Based Biomarkers of Remote Combat-Related Traumatic Brain InjuryCurrent neurology and neuroscience reports20(12), 54.

Ni, Z., Leodori, G., Vial, F., Zhang, Y., Avram, A., Pajevic, S., . . . Hallett, M. (2020). Measuring latency distribution of transcallosal fibers using transcranial magnetic stimulation. Brain Stimulation, 13(5), 1453-1460.

Okonkwo, D., Puffer, R., Puccio, A. Yuh, E., Yue, J.   .  .  . Perl, D. (2020). Point-of-Care Platform Blood Biomarker Testing of Glial Fibrillary Acidic Protein versus S100 Calcium-Binding Protein B for Prediction of Traumatic Brain Injuries: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study. Journal of Neurotrauma.

Stone, J. R., Avants, B. B., Tustison, N., Wassermann, E., Gill, J., Polejaeva, E., Dell, K. C., Carr, W., Yarnell, A. M., LoPresti, M. L., Walker, P. B., O'Brien, M., Domeisen, N., Quick, A., Modica, C. M., Hughes, J. D., Haran, F. J., Goforth, C. W., & Ahlers, S. (2020). Functional and structural neuroimaging correlates of repetitive low-level blast exposure in career breachersJournal of neurotrauma, 10.1089/neu.2020.7141. Advance online publication.


Murphy, E. K., Iacono, D., Pan, H., Grimes, J. B., Parks, S., Raiciulescu, S., Leonessa, F., & Perl, D. P. (2020). Explosive-driven double-blast exposure: molecular, histopathological, and behavioral consequences. Scientific Reports, 10(1), 17446.

Whiting, M. D., Dengler, B. A., Rodriguez, C. L., Blodgett, D., Cohen, A. B.,Januszkiewicz, A. J., . . Brody, D. L. (2020). Prehospital Detection of Life-Threatening Intracranial Pathology: An Unmet Need for Severe TBI in Austere, Rural, and Remote Areas. Frontiers in Neurology, 11. doi:10.3389/fneur.2020.599268


Lippa, S. M., Gill, J., Brickell, T. A., French, L. M., & Lange, R. T. (2020). Blood Biomarkers Relate to Cognitive Performance Years after Traumatic Brain Injury in Service Members and VeteransJournal of the International Neuropsychological Society: JINS, 1–7. Advance online publication.

Oberman, L. M., Exley, S., Philip, N. S., Siddiqi, S. H., Adamson, M. M., & Brody, D. L. (2020). Use of Repetitive Transcranial Magnetic Stimulation in the Treatment of Neuropsychiatric and Neurocognitive Symptoms Associated With Concussion in Military PopulationsThe Journal of head trauma rehabilitation35(6), 388–400.


Esparza, T.J., Martin, N.P., Anderson, G.P., Goldman, E.R., Brody, D.L. (2020). High affinity nanobodies block SARS-CoV-2 spike receptor binding domain interaction with human angiotensin converting enzyme. Scientific Reports, 10, 22370.

Werner, J. K., Shahim, P., Pucci, J. U., Chen, L., Raiciulescu, S., Gill, J. M., Nakase-Richardson, R., Diaz-Arrastia, R., & Kenney, K. (2020). Poor sleep correlates with biomarkers of neurodegeneration in mild traumatic brain injury patients: a CENC StudySleep, zsaa272. Advance online publication.

Williamson, N. H., Komlosh, M. E., Benjamini, D., & Basser, P. J. (2020). Limits to flow detection in phase contrast MRIJournal of Magnetic Resonance Open2-3, 100004.