Our interventional trials strategically address treatment gaps in TBI-related mood, sleep, headache, and cognitive disruptions. These trials will inform and influence clinical practice treatment of concussive TBI sequelae in Service Members. They expand upon previous work and compliment ongoing preclinical, translational, and observational studies.
These interventions apply novel pharmacologic and non-pharmacologic treatment approaches to a variety of symptoms across multiple timespans (e.g., acute, sub-acute, and chronic). Our innovative and clinically relevant trials are designed to be multicenter, randomized, double-blinded, and placebo controlled. In the near future, Bayesian adaptive trial designs will be incorporated to reduce each individual trial’s duration and cost.
This research requires an all-hands approach and is supported by our Clinical Trials Unit, clinical core facilities, Informatics Core, and Program Management team. We are excited to have 2 trials that are ongoing and 7 in development. These trials are captured on our clinical trial pipeline below.