Image Processing Core

Image Processing Core

Image Processing Core

The major functions of the Image Processing Core are as follows:

  • DICOM-compliant image data repository with secure access by CNRM investigators.
  • Provide an array of techniques to maximize the usefulness of the data acquired during MRI/PET imaging to include: data transfer, data management, implementing anonymization procedures, quality control, image registration and enhancement, quantitative structural image analysis with lesion localization, brain region volumetrics, and diffusion applications.


Located on the NIH Bethesda Campus, Clinical Center Building 10, Room B1N264.B


  • Data anonymization and quality control
  • DICOM-compliant image data repository
  • Standard image pre-processing and manipulation
  • Image registration and fusion for enhanced visualization
  • Quantitative structural image analysis
  • Localization of lesions and other regions of brain injury

Data Processed

Includes structural and functional MRI, diffusion tensor MRI, perfusion MRI, computed tomography (CT), and positron emission tomography (PET).

Processing Capabilities

  • Multimodal rigid-body, affine, and deformable image registration
  • Volumetrics for whole brain, total gray matter, total white matter, sulcal and ventricular cerebrospinal fluid volumes, cerebrum, cerebellum, thalamus, putamen, caudate nucleus, brainstem, hippocampus, amygdala, and lesions
  • Cortical thickness measurements for lobar or specific gyral regions
  • Diffusion tensor fiber tracking
  • Fractional anisotropy, mean diffusivity, apparent diffusion coefficient measurements for whole brain, lobes, or white matter tracts
  • Voxel-based morphometry
  • Statistical parametric mapping for functional imaging
  • Tract based spatial statistics
  • Cerebral blood flow, cerebral blood volume, and mean transit time mapping from dynamic susceptibility contrast MRI

Points of contact for information on core resources, policies, and procedures

  • Phone: (301) 435-1673
  • Dr. John Butman, Core PI, Email
  • Dr. Dzung Pham, Core Director, Email

 Access to CNRM core resources is available for CNRM funded studies and for broader research needs according to CNRM policies, including prioritization and cost sharing.  For further information on the policies or for a copy, please email