Acute Studies

The Acute Studies Core

The major function of the Acute Studies Core are as follows:

  • Enable research of acute TBI patients presenting in emergency departments at Level I trauma centers within the National Capital Region for collection and analysis of acute stage variables that impact diagnosis and prognosis.
  • Perform advanced MRI scans within the first hours to days after injury to improve detection of damage from TBI and provide prognostic indicators.
  • Patient recruitment into CNRM studies, including subacute and chronic stage clinical trials.

The Acute Studies Core was established to address the earliest events that inform diagnosis and treatment of TBI.  Since its inception, the Acute Studies Core continues to provide successful implementation of subject contact and enrollment at the earliest event of injury at the clinical site.  The core developed a consortium of local sites expanding the studies to acute patients and recruitment of these patients into other CNRM studies.

The Acute Studies Core has the ability to collect advanced imaging and biomarkers early after injury and follow these patients at the site and/or through other CNRM studies in the sub-acute to chronic phase.  Following study subjects as they recover or experience persistent symptoms permit a more thorough understanding of the relevance of acute imaging findings and clinical presentation.  By bridging the gap between injury at the earliest stage through the evolution to impact on patients’ lives years after injury, the Acute Studies Core and in collaboration with the CNRM Phenotyping cores inform the design of novel diagnostic methods and therapeutic interventions, from acute treatments with neuroprotective agents through to rehabilitation approaches further out from injury.

Our complementary studies between cores take advantage of this early stage information at Level I trauma sites and then extend to both the civilian and military populations at NIH(link is external) and WRNMMC(link is external), respectively. These later stage studies include such measures as re-contact of patients from the acute studies or enrollment of a given patient into a study that starts at a local hospital and continues at the NIH. 

Acute Studies Core Resources and Capabilities

CNRM has established TBI clinical research programs with NINDS collaborative research studies at Johns Hopkins Suburban Hospital in Bethesda, MD(link is external) and MedStar Health Washington Hospital Center in Washington, DC(link is external). Patients from these sites are not only geographically accessible for NIH-based studies, but also demographically diverse, serving as a major pipeline for recruitment into CNRM studies at the NIH Clinical Center. The CNRM Acute Studies Core interactions at local civilian hospitals identify possible study participants as well as those who may be interested in being contacted for involvement in CNRM research protocols.

Acute Studies Core Resources

  • Acute Studies Core Principal Investigator and Project Manager>
  • Acute Studies Core trained clinical research staff at multiple local clinical sites>
  • Acute study data collection and resource sharing>
  • Referral and invitation to participate in CNRM-affiliated studies>
  • Clinical site monitoring>
  • Collaborative research relationships with local civilian sites to exploit advanced technologies and perform interventional studies>

Points of Contact

  • Lawrence Latour, Ph.D, Core PI - Email
  • Martin Cota, Project Manager Acute Studies -  Email

Access to CNRM core resources is available for CNRM funded studies and for broader research needs according to CNRM policies, including prioritization and cost sharing.  For further information on these policies and a copy, please email