Translational Imaging Core

Center for Neuroscience and Regenerative Medicine

Translational Imaging Core

Translational Imaging Core

The major functions of the Translational Imaging Core are as follows:

  • Provide advanced neuroimaging techniques to support in vivo and ex vivo TBI research through (1) Positron Emission Tomography, Single Photon Emission Computed Tomography and Computed Tomography (PET/CT and SPECT/CT), and (2) Magnetic Resonance Imaging (MRI).
  • Provide protocol development, study design, data acquisition, analysis and interpretation.
  • Maintain image processing workstations for image processing software with co-registration, 3D visualization and analysis, pharmacokinetic modeling, automated reference region normalization, rat brain atlas analysis, and region of interest tools.

Facilities

Located on the USU Campus, on the ground floor in and around the LAM facilities.

Mission

Provide state-of-the-art neuroimaging techniques to support in vivo preclinical assessments traumatic brain and spinal cord injury

Core Resources

Siemens Inveon Positron Emission Tomography (PET) scannerSiemens Inveon SPECT/PET/CT Scanner

  • All three modalities docked together in a single scanner
  • Small bore (12 cm)
  • Spatial resolution: 1.5 mm (PET), 1 mm (SPECT), 40 um (CT)
  • Functional PET imaging using 18F-labeled tracers (e.g., FDG )
  • Functional SPECT imaging Tc-99m labeled tracers (e.g., HMPAO)
  • 3D visualization and analysis (5 seats)
  • Pharmacokinetic modeling (5 seats)
  • Dedicated image processing workstation (PET/SPECT/CT)

Bruker BioSpec 70/20 USR Magnetic Resonance Imaging systemBruker BioSpec 70/20 USR Magnetic Resonance Imaging (MRI)  

  • 7T, 660 mT/m gradient strength, 11.4 cm gradient coil (bore size)
  • Volume and phased-array RF coils, 4-8 receiver channels, parallel imaging
  • Auto positioning system
  • Paravision 6.0
  • Dedicated image processing workstation (MRI)

Additional imaging resources may be available through contacting the USU Department of Radiology and Radiological Sciences or the USU Biomedical Instrumentation Center.

Image processing software

VivoQuant, PMOD V3.6, OSIRIX, MatLab, IDL, and Siemens Inveon Research Workplace and various open access software platforms (i.e. SPM, MIPAV, Mango, Amide, DSI Studio, FreeSurfer, ImageJ, FSL, Diffusion Kurtosis Estimator, PETSpectFusion, and TORTOISE)

Computing

The TIF maintains a 32 TB backup server and has dedicated image processing systems running Mac, Windows, and Linux operating systems.

Monitoring and Surgical Equipment  

  • Warming beds, physiological monitoring equipment, isoflurane anesthesia
  • Radioactivity lab, approved Radionuclide Experimental Authorization under core PI

Standard Operating Procedures

Approved and established for SPECT/PET/CT and MRI. Requests for SOP should be sent via email (tif@usuhs.edu)

Service and Scheduling

Please complete the TIF User Request Form (PDF) for service and scheduling requests and e-mail completed form to tif@usuhs.edu

Points of contact for information on core resources, policies, and procedures

Bernard Dardzinski, Ph.D. - Core PI, Translational Imaging Facility - Email, (301) 295-3247

Andrew Hoy, LT, Ph.D. - Director, Translational Imaging Facility - Email, (301) 295-3520

Alexandru Korotcov, Ph.D. - MRI Scientist - Email, (301) 295-9749

 Shalini Jaiswal, M.S. - PET Scientist - Email, (301) 295-5674