The Center for Neuroscience and Regenerative Medicine (CNRM) was established to address the current and future needs of the Department of Defense (DoD) by studying blast-related traumatic brain injury (TBI) and post-traumatic stress (PTS).
The U.S. Congress appropriated funding for CNRM in 2008 (Public Law 110-252), in response to the alarming number of blast-related TBIs sustained by Service Members in Operation Iraqi Freedom and Operation Enduring Freedom. During this appropriation, it was agreed that researchers from the DoD, more specifically the Uniformed Services University (USU), would work together with neuroimaging experts from the National Institutes of Health (NIH) to study blast-related TBI and PTS from combat care patients at Walter Reed National Military Medical Center (WRNMMC), formerly the Walter Reed Army Medical Center and the National Naval Medical Center.
Funding for CNRM continues through DoD funding to USU. USU is responsible, on behalf of the DoD, for CNRM's fiscal management and the coordination of operations. The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF), through a Cooperative Agreement with USU, provides administrative and financial support to CNRM, including support and research at NIH under a Cooperative Research and Development Agreement between HJF and NIH.
Since 2008, CNRM has grown to become a mature intramural interagency expanded to support translational and clinical studies that will build a solid evidence base to influence clinical practice in the treatment of TBI symptoms in Service Members. Since its inception, CNRM has funded a total of 73 translational and 58 clinical research projects, with 31 currently ongoing. CNRM's funded projects have enrolled over 7,500 research participants and have published over 250 publications in journals such as Brain, JAMA Neurology, Annals of Neurology, and the Journal of Neurotrauma.