Center for Neuroscience and Regenerative Medicine (CNRM)

Center for Neuroscience and Regenerative Medicine

Dean of School of Medicine Announces New CNRM Director Appointment

Dr. David Brody, who is considered one of the world’s foremost researchers on traumatic brain injury and neurodegenerative diseases, has been appointed to the Neurology faculty of the F. Edward Hébert School of Medicine and will direct the university’s Center for Neuroscience and Regenerative Medicine (CNRM). Dr. Brody will succeed Dr. Regina Armstrong in the position. Dr. Armstrong will continue with CNRM and serve as its Director for Translational Research to help further build our efforts to advance the research toward the needs of our service members.

Dr. Brody, a board-certified neurologist with both a research and clinical specialization in TBI and neurodegenerative diseases, is currently the Norman J. Stupp Professor of Neurology at the Washington University School of Medicine in St. Louis.  He is also the Washington University site director for the National Football League Neurological player care program. 

Dr. Brody has developed and authenticated advanced imaging techniques to detect injury in the brain’s white matter, and helped show, for the first time, how to predict neurological function by directly measuring amyloid, an abnormal protein in the brain. He also helped discover that diffusion tensor imaging -- an advanced magnetic resonance imaging technique -- can reveal blast-related damage which hadn't been revealed by other imaging methods. These breakthrough findings could lead to better traumatic brain injury diagnosis and treatment in civilian and military populations.

We are thrilled that Dr. Brody is coming to USU to join our faculty and lead the CNRM. Solving the mysteries of traumatic brain injury is one of the greatest challenges facing modern medicine. We are committed to developing effective tests and treatments that will speed recovery and improve the lives of warfighters with TBI. Dr. Brody’s recruitment to USU represents a major step towards that goal.

Dr. Brody will direct an interdisciplinary center comprised of approximately 200 federal subject matter experts. The CNRM spans 16 departments within USU’s School of Medicine and its Daniel K. Inouye Graduate School of Nursing, as well as six National Institutes of Health (NIH) institutes. Clinical partners include Walter Reed National Military Medical Center, the National Intrepid Center of Excellence, Fort Belvoir Community Hospital and Intrepid Spirit One.

The CNRM is focused on advancing and accelerating traumatic brain injury (TBI) research to improve recovery of warfighters.  Dr. Brody previously led a team that worked in partnership with DoD researchers at the Landstuhl Regional Medical Center in Germany and at two sites in Afghanistan treating U.S. military personnel who sustained traumatic brain injury.  In 2011, he served as a consultant to the medical advisor of the Chairman of the Joint Chiefs of Staff, traveling to Afghanistan at the request of then-JCS Chairman Admiral Michael Mullen with the “Gray Team” group of civilian and military experts evaluating the status of TBIs in troops in the combat zone.

Dr. Brody’s achievements have been recognized with several awards, including a Career Development Award from the National Institute of Neurological Disorders and Stroke (NINDS), a Burroughs Wellcome Career Award in the Biomedical Sciences, two large Department of Defense awards and a National Institutes of Health (NIH) R01 award. 

Dr. Brody has published extensively on TBI and related effects. He and his laboratory team at the Washington University in St. Louis are actively involved in studies of concussive traumatic brain injury, chronic traumatic encephalopathy and the increased risk of Alzheimer’s disease following moderate to severe traumatic brain injury.  In 2012, he won the Washington University School of Medicine’s Distinguished Investigator Award.  His clinical monograph entitled Concussion Care Manual: A Practical Guide was published by Oxford University Press in 2014.  Dr. Brody is a member of the Editorial Board of the Journal of Neurotrauma and Acta Neuropathologica and a permanent member of the NIH Acute Neural Injury and Epilepsy study section.  He is the co-organizer of the Axon Injury and Repair Research Interest Group (part of the Hope Center for Neurological Disorders) and is a member of the Division of Biology and Biomedical Sciences in the Neurosciences Program.

In addition to directing the CNRM, Dr. Brody will conduct collaborative research with laboratory scientists at the NINDS.  According to NINDS director, Dr. Walter Koroshetz, Dr. Brody “is a world-class investigator who is well suited to lead the joint USU-NIH effort to advance the science of TBI.”    

Dr. Brody received his bachelor’s degree from Stanford University in 1992 and his medical and doctoral degrees from The Johns Hopkins School of Medicine in 2000. He completed his internship and neurology residency at Washington University. 

He will fully assume his duties at USU and the NIH in August. A video link to Dr. Brody's TEDxGatewayArch talk can be found here

 

The Center for Neuroscience and Regenerative Medicine (CNRM), an entity of the Uniformed Services University (USU), serves as the translational engine for advancing traumatic brain injury (TBI) research in the heart of the National Capital Area.  The CNRM mission is to catalyze innovative research on TBI that leverages resources and investigators on America's Health Campus to more effectively diagnose and treat Warfighter injuries and prevent long-term consequences resulting from TBI.

CNRM is a unique intramural federal research collaboration bringing together the expertise of investigators from the U.S. Department of Defense and the National Institutes of Health (NIH).  The USU is responsible for the fiscal management as well as the establishment and operation of CNRM.  

CNRM addresses the full spectrum of TBI with special focus on militarily relevant forms of TBI resulting from blast, penetrating, and repetitive trauma to the head, including the effect of high stress conditions and the concurrent development of posttraumatic stress disorder (PTSD).  The Center's overall goal is to advance and accelerate TBI research to improve recovery of the Warfighter.  Specific short-term objectives are:

    1.  Innovate treatments for the Warfighter based on the pathophysiological mechanisms of military TBI.

    2.  Establish non-invasive individualized assessments for TBI diagnosis and treatment.

    3.  Implement strategies to redefine clinical trial design.

    4.  Optimize TBI clinical trial processes for recruitment, administration, and support.

    5.  Promote interdisciplinary collaborative processes to accelerate TBI research.

The research objectives are supported by access to state-of-the-art core facilities for imaging, acute studies, animal modeling and behavioral testing, microscopy, informatics, recruitment, neuropathology, and biospeciman repository support.  These CNRM resources and expertise come together to support the overarching goal of an integrated research program in which pre-clinical and clinical investigators interact closely and continuously learn from each other to accelerate research and translation to patient care.

 

CNRM Research Programs

The CNRM Research Programs have an emphasis on aspects of high relevance to the military populations, with a primary focus on patients at the Walter Reed National Military Medical Center.  Due to the impact of TBI among military populations, the CNRM seeks to serve as the catalyst for collaboration, innovation, and advancement of knowledge of the incidence of TBI and associated co-morbidities, and the identification of interdisciplinary approaches to assess and promote recovery. 

 

CNRM Clinical Studies

CNRM Clinical Research Studies The CNRM's Clinical Research Studies focus on improving the diagnosis and care of TBIs for both military service members and civilians.  CNRM supports ongoing clinical research at military treatment facilities, the National Institutes of Health, and local civilian hospitals.  Please visit the CNRM's Clinical Research Studies website to learn more about currently recruiting research opportunities.

 

 

 

 

 CNRM Brain Tissue Repository 

Brain Tissue RepositoryThe CNRM's Brain Tissue Repository was established to give scientists and physicians a better understanding and more innovative approaches to better care for our military personnel after a head injury. Please visit CNRM Brain Tissue Repository website to learn more about currently recruiting research opportunities.

  

 

 

 

 

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A Catalyst for Brain Injury Research