The Neuroplasticity Program will focus on recovery approaches that modify synapses and circuits to enhance functional capacity. Neuroplasticity strategies will attempt to maximize function from existing cells as a critical component of promoting recovery from traumatic brain injury (TBI). Neuroplasticity studies will assist the development of neuroregenerative strategies since newly generated cells must establish the appropriate neuronal-glial interactions and/or integrate into the appropriate circuitry to contribute to the recovery of function.
Neuroplasticity Program Primary Goals:
- Understand the biological consequences of traumatic brain injury (TBI) that impair central nervous system structural and functional repair.
- Develop neurobiological approaches to aid recovery of neurological and cognitive function.
- Characterize neural maps within the cerebral cortex and limbic system that are associated with the changes resulting from TBI and possibly altered with treatment.
Critical Issues for the Neuroplasticity Program:
- Underlying predictors of impaired cognitive and sensory motor learning skills accompany many forms of TBI.
- Environmental stress affects TBI symptomatology.
- Diffuse axonal injury is associated with specific forms of TBI and can disrupt function throughout diverse neural circuits.
- Glial and immune response in TBI can alter neuronal function.
Neuroplasticity Program Research Projects and Pilots
To view all CNRM funded research projects:
- Visit the Federal RePORTER website
- Next to Agency, click "Select"
- From the drop down, click "Clear"
- Select the + by "Defense" and click the box for "Center for Neuroscience and Regenerative Medicine"
- Click "Select" and then "Submit Query"