Our Translational Research Division conducts preclinical traumatic brain injury (TBI) studies that closely mirror human clinical studies. This novel approach enhances our ability to translate preclinical treatments into successful future clinical trials that will improve outcomes for Service Members with TBI.
The Translational Research Division is comprised of the Translational Therapeutics Core, the Optimizing Ferret TBI Experiment, the Translational Imaging Facility, and the Preclinical Studies Core. These groups collaborate closely to develop and conduct robust studies that are closely aligned with human pathophysiology, are clinically relevant, and are highly aligned with the military TBI patient experience. Preclinical investigators regularly consult with subject matter experts within the clinical core facilities, the Clinical Trials Unit, and the Informatics Core to ensure their efforts parallel human study standards.
Our Translational Research Division has an impressive array of capabilities that include:
- A variety of complex injury models that closely replicate military-related TBIs: a combination of blast exposure and/or impact and rotational forces with stress-inducing environmental stimuli
- Assessment of symptomology analogous to those measured in human trials: disruptions in mood (e.g., depression, anxiety), sleep, pain/headache, attention, impulsivity, and cognition (e.g., memory)
- Application of interventional timelines that mimic human study standards: acute (one day), sub-acute (30 days), and chronic (6-12 months)
- The use of advanced, state-of-the-art neuroimaging capabilities that are also used in human studies: Positron Emission Tomography, Single Photon Emission Computed Tomography and Computed Tomography (PET/SPECT/CT); and Magnetic Resonance Imaging (MRI)
- Integration of clinical trial standards: randomization; blinding; dosing; safety and toxicity assessments; exploration of age and sex as biological variables; and scalability to both larger animal models and human models
On the menu items to the left you'll find more information about the Translational Therapeutics Core, the Optimizing Ferret TBI Experiment, the Translational Imaging Facility, and the Preclinical Studies Core.