USUHS Molecular & Cell Biology Seminar
“Post-transcriptional regulation of the centrosome scaffolder Pericentrin-like protein”
Dorothy A. Lerit, PhD
Department of Cell Biology
Emory University School of Medicine
Dr. Lerit completed her undergraduate studies at the University of Massachusetts at Amherst, where she was a University Scholar Merit Award recipient and graduated magna cum laude. She earned her Ph.D. at Princeton University under the mentorship of Dr. Elizabeth Gavis, where she was supported by a T32 fellowship. Dr. Lerit was an Intramural Research Training Award (IRTA) Postdoctoral Fellow in the laboratory of Dr. Nasser Rusan at the NHLBI at the NIH. Dr. Lerit is the recipient of a Lenfant Biomedical Research Fellowship and an NHLBI Career Transition Award (K22). She was recruited to Emory in 2016.
CENTROSOMES IN DEVELOPMENT & DISEASE
Centrosomes are the microtubule organizing centers of most eukaryotic cells tasked with building the bipolar mitotic spindle that segregates the duplicated genome into two daughter cells during cell division. As such, centrosomes are integral to maintaining genome stability. Centrosomes orchestrate numerous critical tasks beyond cell division: cell polarization and migration, intracellular trafficking, and ciliogenesis. Given these critical roles, centrosome dysfunction is the leading cause of microcephaly and is also associated with sterility, ciliopathy, poor cancer prognosis, and other disorders. Cell cycle-dependent oscillations in composition and organization contribute to the multifunctional nature of centrosomes. We study how these dynamic changes instruct centrosome activity and function. Our goal is to elucidate mechanisms of centrosome regulation in the context of normal development and how these regulatory paradigms go awry in models of human disease or developmental disorders.
Thursday, April 8, 2021
Seminar Host - Dr. Smyth