Molecular & Cell BIO Seminar


Molecular & Cell BIO Seminar

Event Date/Time: 
November 21, 2019 - 3:30pm to 4:30pm

Building A, Lecture Hall A3


Assistant Professor, Department of Biological Sciences

University of Delaware

Newark, DE

Teaching - Introduction to Microbiology & Advanced Topics in Host-Microbe Interaction

Research Interests - To survive in eukaryotic cells, intracellular bacteria have evolved complex mechanisms that maintain the delicate balance between exploiting and preserving host cellular resources. Our group investigates the cellular and molecular mechanisms that bacterial pathogens use to survive and replicate inside host cells. Our model system is Legionella pneumophila, a Gram negative bacterium commonly found as an endosymbiont of amoebae in fresh water and soil. L. pneumophila is also an opportunistic pathogen and infects human alveolar macrophages upon inhalation of contaminated aerosols causing a severe form of pneumonia known as Legionnaires' disease. L. pneumophila is internalized into host cells by phagocytosis and remains enclosed in a membrane-bound compartment that the pathogen “remodels” in order to escape degradation by the host and support bacterial growth. Over the course of infection, L. pneumophila translocates more than 300 effector proteins into the host cytosol through a specialized secretion system. These effectors manipulate host proteins to subvert eukaryotic cellular pathways.


Thursday, November 21, 2019


Lecture Hall A3 (formerly C)

Seminar Host - Dr. Satpute-Krishnan