Preventive Medicine & Biostatistics

The Department of Preventive Medicine and Biostatistics (PMB) is one of the largest departments within the School of Medicine and its standing follows from the prominence of public health in the mission of the Department of Defense. The mission of the PMB Department is "to enhance health in human populations through medical education, research, and service that support and improve programs of preventive medicine, community health, and health promotion in the uniformed services."

James Mancuso, MD

Name: James Mancuso, MD, MPH, DrPH, LTC, MC, USA

Department of Primary Appointment: Preventive Medicine & Biostatistics
Position: USU Faculty
Title: Director of TPH, Assistant Professor

Email: (link sends e-mail)

Department Website



LTC Mancuso currently serves as an active duty Army physician, assistant professor in the Department of Preventive Medicine and Biometrics, and Director of the Division of Tropical Public Health. LTC Mancuso hails from Boston's North Shore but has lived for much of the past 20 years in the Washington, DC area. After completing medical school at USUHS, LTC Mancuso completed residency training in Preventive Medicine and Public Health at the Walter Reed Army Institute of Research (WRAIR), which also included completing an MPH at the Johns Hopkins School of Public Health. After residency, LTC Mancuso had several assignments as an Army public health official and epidemiologist at Fort Stewart, Georgia and Landstuhl, Germany, respectively. During these assignments, he also had the opportunity to deploy to Iraq in 2003 as Division Preventive Medicine Officer for the 3rd Infantry Division and to Pakistan in 2005 in support of earthquake relief efforts. LTC Mancuso then returned to USUHS to complete a Doctorate in Public Health, where he studied TB control in the U.S. military, and where he completed the ASTMH Certificate Course in Tropical Medicine. From 2009 to 2013, he ran the Preventive Medicine residency at WRAIR, training physicians in public health and preventive medicine. Since 2013, he has served as the Director of Tropical Public Health at USUHS.


  • M.D., USUHS
  • MPH, Johns Hopkins School of Public Health and Hygiene


LTC Mancuso's research interests include TB control, particularly in military populations, but also in HIV coinfection and drug-resistant TB.


LTC Mancuso co-direct's the travel medicine course, and teaches several other courses in the MPH and medical school curriculum, including epidemiology, tropical medicine, and doctoral student seminar. He also teaches residents in TB and STI clinics in the DC area and is on the faculty of the Preventive Medicine residency at WRAIR.

Areas of Expertise

LTC Mancuso advises the Army on TB control policy, including the development of the 2013 MEDCOM regulation 40-64, "The Tuberculosis Surveillance and Control Program." He also consults on management of TB cases and other outbreaks, and assists and consults in the area of Graduate Medical Education in Preventive Medicine.

Selected Recent Publications

  • Ambrose J, Hampton LM, Fleming-Dutra KE, Marten C, McClusky C, Perry C, Clemmons NA, McCormic Z, Peik S, Mancuso J, Brown E, Kozak N, Travis T, Lucas C, Fields B, Hicks L and Cersovsky SB. Large outbreak of Legionnaires' disease and Pontiac fever at a military base. Epidemiol Infect 2014; doi:10.1017/S0950268813003440; in press.
  • Mancuso JD, Aronson NE, Keep LW. Can the active component U.S. military achieve tuberculosis elimination? MSMR 2013;20(5):2-3.
  • Mancuso JD, Aaron CL. Tuberculosis trends in the U.S. Armed Forces, active component, 1998-2012. MSMR 2013;20(5):4-8.
  • Aaron CL, Mancuso JD. Using the tuberculosis cohort review to evaluate and improve the U.S. Army's tuberculosis control program. MSMR 2013;20(5):9-13.
  • Aaron CL, Fotinos MJ, West KB, Goodwin DJ and Mancuso JD. Tuberculosis among nonimmigrant visitors to U.S. military installations. Mil Med 2013;178(3):346-352.
  • Mancuso JD, Bernardo J, and Mazurek GH. The Elusive "Gold" Standard for Detecting Mycobacterium tuberculosis infection. AJRCCM 2013 Jan 14;187(2):122-4.
  • Cohen RL, Li Y, Giese R, Mancuso JD. An evaluation of PEPFAR's Effect on Health Systems Strengthening in Sub-Saharan Africa. JAIDS 2012 Dec 18.
  • Mancuso JD, Mazurek GH, Tribble D, Olsen C, Aronson NE, Geiter L, Goodwin D, and Keep LW. Discordance Among Commercially-Available Diagnostics for Latent Tuberculosis Infection. Am J Resp Crit Care Med 2012:185(4):427-34.
  • Bedno SA, Soltis MA, Mancuso JD, Burnett DG, and Mallon TM. The In-Service Examination Score as a Predictor of Success on the American Board of Preventive Medicine Certification Examination. Am J Prev Med 2011:41(6):641-644.
  • Mancuso JD, Niebuhr DW, Frick KD, Keep LW, and Anderson KM. Cost-effectiveness analysis of targeted and sequential screening strategies for latent tuberculosis. Int J Tuberc Lung Dis 2011:15(9);1223-30.
  • Mancuso JD, Tribble D, Mazurek GH, Li Y, Olsen C, Aronson NE, Geiter L, Goodwin D, and Keep LW. Impact of Targeted testing for Latent Tuberculosis Infection Using Commercially Available Diagnostics. Clin Infect Dis 2011:53(3);234-244.
  • Whitman TJ, Herlihy RK, Schlett CD, Murray PR, Grandits GA, Ganesan A, Brown M, Mancuso JD, Adams WB, Tribble DR. Chlorhexidine-impregnated cloths to prevent skin and soft-tissue infection in marine recruits: a cluster-randomized, double-blind, controlled effectiveness trial. Infect Control Hosp Epidemiol 2010 Dec;31(12):1207-15.
  • Mancuso JD, Tobler SK, Eick AA, Olsen CH. An evaluation of the completeness and accuracy of active tuberculosis reporting in the US military. Int J Tuberc Lung Dis 2010;14(10):1310-1315.
  • Mancuso JD, Tobler SK, Eick AA, Keep LW. Active tuberculosis and recent overseas deployment in the US military. Am J Prev Med. 2010 Aug;39(2):157-163.
  • Freeman RJ, Mancuso JD, Riddle MS, Keep LW. Systematic review and meta-analysis of TST conversion risk in deployed military and long-term civilian travelers. J Travel Med. 2010 Jul;17(4):233-42.

Professional Activities

LTC Mancuso is a Fellow of and serves on the Board of Regents for the American College of Preventive Medicine. He was elected into the Delta Omega honorary public health society in 2000. He is also a member of ASTMH, IUATLD, AMSUS, and other organizations, and sits on the Board of the Johns Hopkins Tropical Medicine Dinner Club.


David F. Cruess, PhD

Name: David F. Cruess, PhD

Department of Primary Appointment: Preventive Medicine & Biostatistics
Position: USU Faculty
Title: Principal Vice Chair of PMB, Vice Chair for Biometrics Professor, Graduate Programs Director of Biostatistics Consulting Center

Affiliated Departments: Emerging Infectious Diseases,

Email: (link sends e-mail)
Office Phone: (301) 295-3465
Room: Bldg. A, Room A1044

Department Website



Dr. Dave Cruess currently serves as Professor of Preventive Medicine and Biometrics (PMB), with a secondary appointment as Professor of Emerging Infectious Diseases. He additionally serves as the Graduate Programs Director of PMB. He also holds the administrative positions of Principal Vice Chair of PMB, Vice Chair for Biometrics, and Vice Chair for Graduate Programs. Dr. Cruess is the senior Biostatistician in the Department, and founded the Biostatistics Consulting Center for the University. He designed and taught much of the biostatistical curricula for the USU medical and graduate school.


Ph.D.,The Johns Hopkins University


The research interests of Dr. Cruess are varied, but most deal with the application of biostatistical methods in innovative ways to biomedical problems, especially in the areas of radiology, telemedicine, dermatology, and surgery. Currently, he is involved with research that involves the evaluation of the long-term outcomes of USU medical school graduates.


Dr. Cruess designed and teaches the core Biostatistics I course that is a required course for most graduate programs at USU. He has won the "Outstanding Educator of the Year" six times for his teaching expertise.

Areas of Expertise

Dr. Cruess is the only member of the Department to be "Certified in Public Health" by the National Board of Public Health Examiners. He has extensive expertise in the area of educational program administration, especially in accreditation issues. He has had a major role in every accreditation and re-accreditation effort of the Department, and has chaired the last two accreditation Self-studies for the Council for Education in Public Health (CEPH).

Selected Recent Publications

Personal satisfaction and mentorship are critical factors for today's resident surgeons to seek surgical training. Lukish J, Cruess D, and the Executive Committee of the Resident and Associate Society of the American College of Surgeons. American Surgeon 71(11):971-4, 2005.

Expression of the proto-oncoprotein Brx is altered in eutopic endometrium of women with endometriosis. R Hearns-Stokes, C Mayers, C Zahn, D Cruess, J Gustafsson, J Segars, and L Nieman. Fertility and Sterility 85(1):63-70, 2006.

Laparoscopic appendectomy in children: Endoloop or endostapler? Lukish J, Powell D, Morrow S, Cruess D, Guzzetta P. Archives of Surgery. 142(1):58-61, 2007

Identifying medical students likely to exhibit poor professionalism and knowledge during internship. Greenburg D, Durning S, Cohen D, Cruess D, Jackson J. Journal of General Internal Medicine 22(12):1711-7, 2007

Long-term Career Outcome of Uniformed Services University of the Health Sciences Medical School Graduates; Classes of 1980-1989. Durning SJ, Cohen D, Cruess D and MacDonald R Military Medicine 173(5):422-428, 2008

Does Student Promotions Committee (SPC) Appearance Predict Below Average Performance During Internship? Durning SJ, Cohen D, Cruess D and MacDonald R. Teaching and Learning in Medicine 20(3):267-272, 2008)

Faculty performance evaluation in accredited US public health graduate schools: A national study. Gimbel R, Cruess DF, Schor K, Hooper T, and Barbour G. Academic Medicine 83(10):962-8, 2008.

The prevalence, causes, and consequences of experiencing a life crisis during medical school. Greenburg D, Durning SJ, Cruess D, Cohen D, and Jackson J. Teaching and Learning in Medicine 22(2):85-92, 2010

Low dose quetiapine causes a statistically significant increase in weight: A retrospective chart review of military healthcare beneficiaries. William SG, Alinejad NA, Lamb JA, and Cruess DF. Pharmacotherapy 30(10):1011-5, 2010

The Long-Term Career Outcome Study (LtCOS): Where we've been and where we hope to go. Durning SJ, Artino AR, Gilliand WR, Cruess DF, McManigle, and Waechter D. Military Medicine 175(3):133-5, 2010

Almost internists: Analysis of students who considered internal medicine but chose other fields. Durning SJ, Elnicki M, Cruess D, Schwartz M, and Hauer KE. (to appear in Academic Medicine)

Performance in medical school and internship: Does self-reported clinical experience matter? Artino AR, Guilland WR, Waechter DM, Cruess DF, Dezee K, Calloway M, Durning SJ. (submitted for publication in Medical Education)

Professional Activities

Dr. Cruess is a Fellow of the American College of Epidemiology and was elected in the Delta Omega honorary public health society. He is also a member of the American Statistical Association, the International Biometric Society, and the Association for Prevention Teaching and Research.

Aizen Marrogi, MD

Name: Aizen Marrogi MD, COL, USA

Department of Primary Appointment: Preventive Medicine & Biostatistics
Position: USU Faculty
Title: Adjunct Assistant Professor, Global Health Division

Email: (link sends e-mail)

Department Website



COL Aizen Marrogi is a currently a faculty member within the division of Global Health, Department of Preventive Medicine and Biometric, USUHS in Bethesda, MD. He recently returned from an overseas deployment as a command surgeon for the office of security Cooperation (OSC-I) with US mission in Baghdad, Iraq. Where he served as medical advisor to the chief of the office of Security Cooperation on all health matters regarding immunization, health force protection of US uniformed, DoD civilian and contractors. He initiated more than half a billion in medical Foreign Military Sales in support of US modernization effort of Iraqi Security Forces including the F-16 and Apache programs. He is also the US Army Surgeon General Liaison office the Iraqi Ministry of Defense. In this capacity, he coordinates with Iraqi MOD, CentCom, OTSG and MTFs for Training of the Iraqi Health care providers from MOD. He completed a commander appointment position as the Chair of the Institutional review Board (IRB) tasked with approving all human subject research through-out Walter Reed Army Research Institute (WRAIR) Worldwide operation. He is also staff pathologist at the new Walter Reed National Medical center in Bethesda, MD.

COL Marrogi is a designator "A" which is the highest academic title within the DoD Medical Department, and his awards include Meritorious Service Medal (twice), Army Achievement Medal, Army Commendation Medal, National Defense Ribbon (twice), Army Service Ribbon, Overseas Reserve Ribbon, Reserve Component Overseas Training Ribbon, Flight Surgeon Wing, Global War on Terrorism Medal.

Col Marrogi is proud of his Chaldean and Iraqi Heritage. He speaks, reads and writes in Syriac, Arabic and French languages.

Medical Education and Training

  • M.D. University of Baghdad, Baghdad, Iraq
  • Resident in Anatomic Pathology (PGY-I and II), Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, and University of Michigan, Ann Arbor MI
  • Resident in Clinical Pathology (PGY-III and 1V) Grand Rapids Area Medical Educational Center Residency Program (GRAMEC), Grand Rapids, MI
  • Fellow in Surgical Pathology, Department of Pathology, St. John Mercy Medical Center, St. Louis, MO
  • Fellow in Dermatopathology, Department of Pathology, Barnes Hospital, St. Louis, MO
  • Medical Staff & Senior Staff Fellow, National Cancer Institute (Intramural Program), Laboratory of Human carcinogenesis, NIH, Bethesda, MD


Dr. Marrogi's research interests are in Cancer Biology and Carcinogenesis, in particular the role of oxidative stress and redox regulatory pathways, gene therapy, molecular biomarkers and epidemiology. In addition to his work on the in-silco drug discovery, he has been exploring the role of plants phenolics extracts on several disease models including, Malaria, and Cancer. He has authored more than 150 original and review papers, abstracts and book chapters. He is a reviewer for a dozen medical journals and has served on several Grant Review Study Sections for both the department of Defense and National Institutes of Health. He is the founder of the United State Military Cancer Institute Bio-specimen Network which represents a Department of Defense effort in supporting National Cancer Institute's drive to acquire human samples for medical research. He is developing a program in effect of UV exposure on skin and immunity in deployed US troops. He is also actively engaged in designed a study of prevalence of no- neoplastic lung diseases in Iraqi native population. He is a great advocate of using soft powers such as Medicine and Science as to promote US Strategic partnership with Arab and Muslim world. He recently wrote an article to be published in Joint Forces Quarterly in April, 2014 entitled "Medical Diplomacy in International Relations: Concepts and Roles in Achieving US Global Strategic Objectives".

Research Interests

Cancer biology and carcinogenesis; molecular biomarkers, epidemiology; Bio-repository; and Botanical Drug Discovery for Oncology and Military Medicine.

Brief Chronology of Employment and Training

  • 2013-2013: Staff Scientist, Veterinary Service Program, Walter Reed Army Institute of Research, Silver Spring, MD
  • 2012-2013: Surgeon - Office of Security Cooperation, US Embassy, Baghdad, Iraq
  • 2009-2011: Institutional Review Board Chair, Walter Reed Army Institute of Research
  • 2008-2009: Chief, Chemical-Biological program, Division of Experimental Therapeutics Walter Reed Army Institute of Research
  • 2001-2008: Staff Pathologist, Walter Reed Army Medical Center, Department of Pathology and Area Laboratory Medicine, Washington, DC
  • 1997-1998: Associate Professor, Department of Pathology and Surgery Louisiana State University, School of Medicine, New Orleans, LA
  • 1992-1997: Director of Histology and Dermatopathology, Program Director, Dermatopathology Fellowship, Assistant/Associate Professor, Department of Pathology and Laboratory Medicine Tulane University, School of Medicine, New Orleans, LA


Books: 4
Peer-Reviewed publications: 70
Chapters: 8
Book reviews: 2
Abstracts: 72
Clinical Protocols: 8
Oral or Poster Presentations: 4


Original Work

Marrogi. A. J., Duilami, S.: Medical Diplomacy in International Relations: Concepts and Roles in Achieving US Global Strategic Objectives. Joint Forces Quarterly, April, 2014

Levin,L.I., Kitchen, C. M. R., Liao, E., Kim, B., K., Marrogi, A., J., Widney, D., Krampf , R., Magpantay, L, Breen, E., Martínez-Maza, O. Elevated serum levels of CXCL13 precede the diagnosis of B cell non-Hodgkin lymphoma, Submitted to JNCI.

Schwarzenberger, P., Byrne, Gaumer, R., Norton, J., Harrison, J, Marrogi, A. J., Kolls , J. Intra-Tumoral Drug Assessment of Mesothelioma Patients Following Treatment with PA1STK Cells and Ganciclovir. Can Gen Therapy 2011, 18:906-12.

Enewold L, Zhou J, Devesa SS, Berrington de Gonzalez A, Anderson WF, Zham SH, Stojadinovic A, Peoples GE, Marrogi AJ, Potter JF, McGlynn KA, Zhu K. Thyroid cancer incidence among active duty U.S. military, 1990-2004. Cancer Epidemiol Biomarkers Prev. 2011, 20:2369-76

Professional Activities

Professional Societies, Membership
  • American Association of Cancer Research (AACR)(1997-current)
  • American Society of Clinical Oncology (ASCO)(2006)
  • American Association for the Advancement of sciences (AAAS)(1994)
  • American Society of Clinical Pathology (ASCP)(1990)
  • American Society of Dermatopathology (ASDP)(1991)
  • American Society of Gene Therapy (ASGT)(1995)
  • College of American Pathologists (CAP)(1989)
  • International Society of Cutaneous Cell Lymphoma (ISCL)(1993)
  • United States and Canadian Academy of Pathology (USCAP)(1989)
  • The Washington Dermatological Society (2007)
Peer Review Journal Editorial Staff
Peer Reviewer
  • Study Sections Peer Reviewer
  • Member of the Stakeholder panel CDMRP. Malignant Melanoma and New Global War on Terrorism: Impact of UV and Sun Exposure during over-seas deployments, February 23-24, 2009, Great Falls, VA.
  • Government Liaison, CDRPR/Institute of Biological Sciences Review panel, Leishmanial disease , September 21-23, 2008.
  • Member of the National Institutes of Health Review Panel Special Emphasis Panel/Scientific Review Group 2007/10 ZCA1 SRRB-3 (O1). Scientific Review Administrator; LALITA PALEKAR, PHD. Special Review and Logistics Branch, National Cancer Institute, June 21, 2007.
  • Member of the National Institutes of Health Review Panel, RFA CA-07-003, 10, 11, "Innovations in Cancer Sample Preparation". Scientific Review Administrator; Courtney Michael Kerwin, PhD, MPH, Special Review and Logistics Branch, National Cancer Institute, June, 2006.
  • Ad-hoc member of Peer-Reviewed Medical Research Program, Department of Defense, Congressionally Directed Medical Research Programs (CDMRP), September, 2006.
  • Member of the National Institutes of Health Review Panel, RFA CA-07-003, 10, 11, "Innovations in Cancer Sample Preparation". Scientific Review Administrator; Courtney Michael Kerwin, PhD, MPH, Special Review and Logistics Branch, National Cancer Institute, June, 2006.
  • Member of the National Institutes of Health Review Panel, RFA CA-06-004, "Innovations in Cancer Sample Preparation" and RFA CA-006-007 "Innovations in Cancer Sample Preparation (SBIR/STTR), June, 2005.
Journals Peer Reviewer
  • Lung Cancer
  • Molecular Cancer Therapeutics
  • Archives of Pathology and Laboratory Medicine
  • American Journal of Respiratory Cell and Molecular Biology
  • American Journal of Surgical Pathology
  • Cancer Research
  • Carcinogenesis
  • Environmental Health Perspective
  • Journal of American Medical Sciences
  • Journal of Cutaneous Pathology
  • Journal of Hematotherapy
  • Journal of the National Cancer Institute
  • International Journal of Cancer
  • Journal of health for the Poor and Underserved
Language Proficiency
  • Classic Arabic, and Iraqi, Gulf and Egyptian dialects (DLPT Level 3)
  • French, Syriac (Modern Aramaic)
  • Spanish and German (comprehend and read)


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