Chantal M. Moratz, Ph.D.

Chantal M. Moratz, Ph.D.

Name: Chantal M. Moratz, Ph.D.

Department of Primary Appointment: Dept. of Medicine
Position: USU Faculty
Title: Assistant Professor

Email: chantal.moratz@usuhs.edu (link sends e-mail)
Office Phone: (301) 295-0197
Fax Number: (301) 319-0680

Profile

  • Ph.D. University of Alabama at Birmingham
  • Post-doctoral training: NIAID/NIH

Research: Regulatory mechanisms of inflammation, Complement proteins, Autoimmunity, Neuro-inflammation

I have maintained a long term interest in the regulation of inflammatory responses and how the complex interactions of G-protein coupled receptors (chemokine receptors; complement receptors, and sphingoshine-1 phosphate receptors) influence the maintenance and/or resolution of inflammation.   My early training was in developmental immunology, which progressed to regulation of immune responses in wild type and autoimmune models.  Work in the laboratory continues to explore the mechanisms of pathogenic inflammation in a murine model of Systemic Lupus Erythematosus (SLE).   My interests have expanded to address the immune processes contributing to pathogenic sustained inflammation due to injury.  In collaborative efforts my laboratory has developed a model of vascular injury utilizing High Intensity Focused Ultrasound.  With this model we have evaluated the neuro-inflammatory response over time in response to injury and have defined repeated injuries lead to sustained neuro-inflammatory microenvironments in the vascular unit with long term neuropathology and cognitive deficiencies.  Understanding how inflammation at the barrier promotes long term alterations/detiriation of neuronal function is applicable to a wide range of medical concerns.  The laboratory will be using this model to investigate vascular injury in neuropsychiatric SLE in the murine model.

Bibliography

Beckwith, M., C. M. Moratz, et al. (1989). "Analysis of isotype switch variants of a Qa-5 specific hybridoma." J Immunol Methods 123(2): 249-257.

Beckwith, M., W. J. Urba, et al. (1991). "Anti-IgM-mediated growth inhibition of a human B lymphoma cell line is independent of phosphatidylinositol turnover and protein kinase C activation and involves tyrosine phosphorylation." J Immunol 147(7): 2411-2418.

Dalle Lucca, J. J., M. Simovic, et al. (2011). "Decay-accelerating factor mitigates controlled hemorrhage-instigated intestinal and lung tissue damage and hyperkalemia in swine." J Trauma 71(1 Suppl): S151-160.

Edgerton, C., J. C. Crispin, et al. (2009). "IL-17 producing CD4+ T cells mediate accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice." Clin Immunol 130(3): 313-321.

Han, S. B., C. Moratz, et al. (2005). "Rgs1 and Gnai2 regulate the entrance of B lymphocytes into lymph nodes and B cell motility within lymph node follicles." Immunity 22(3): 343-354.

Harris, J. V., T. M. Bohr, et al. (2012). "Sequential Plasmodium chabaudi and Plasmodium berghei infections provide a novel model of severe malarial anemia." Infect Immun 80(9): 2997-3007.

Kearney, J. F., W. J. Won, et al. (1997). "B cell development in mice." Int Rev Immunol 15(3-4): 207-241.

Keith, M. P., C. Moratz, et al. (2007). "Anti-ribonucleoprotein antibodies mediate enhanced lung injury following mesenteric ischemia/reperfusion in Rag-1(-/-) mice." Autoimmunity 40(3): 208-216.

Keith, M. P., C. Moratz, et al. (2007). "Anti-RNP immunity: implications for tissue injury and the pathogenesis of connective tissue disease." Autoimmun Rev 6(4): 232-236.

Kenny, J. J., C. M. Moratz, et al. (1992). "Antigen binding and idiotype analysis of antibodies obtained after electroporation of heavy and light chain genes encoding phosphocholine-specific antibodies: a model for T15-idiotype dominance." J Exp Med 176(6): 1637-1643.

Kulik, L., S. D. Fleming, et al. (2009). "Pathogenic natural antibodies recognizing annexin IV are required to develop intestinal ischemia-reperfusion injury." J Immunol 182(9): 5363-5373.

McCabe, J. T., C. Moratz, et al. (2014). "Application of high-intensity focused ultrasound to the study of mild traumatic brain injury." Ultrasound Med Biol 40(5): 965-978.

Moratz, C., K. Harrison, et al. (2004). "Regulation of chemokine-induced lymphocyte migration by RGS proteins." Methods Enzymol 389: 15-32.

Moratz, C., K. Harrison, et al. (2004). "Role of RGS proteins in regulating the migration of B lymphocytes." Arch Immunol Ther Exp (Warsz) 52(1): 27-35.

Moratz, C., J. R. Hayman, et al. (2004). "Abnormal B-cell responses to chemokines, disturbed plasma cell localization, and distorted immune tissue architecture in Rgs1-/- mice." Mol Cell Biol 24(13): 5767-5775.

Moratz, C., V. H. Kang, et al. (2000). "Regulator of G protein signaling 1 (RGS1) markedly impairs Gi alpha signaling responses of B lymphocytes." J Immunol 164(4): 1829-1838.

Moratz, C. and J. H. Kehrl (2004). "In vitro and in vivo assays of B-lymphocyte migration." Methods Mol Biol 271: 161-171.

Rabin, R. L., M. A. Alston, et al. (2003). "CXCR3 is induced early on the pathway of CD4+ T cell differentiation and bridges central and peripheral functions." J Immunol 171(6): 2812-2824.

Shi, G. X., K. Harrison, et al. (2004). "Toll-like receptor signaling alters the expression of regulator of G protein signaling proteins in dendritic cells: implications for G protein-coupled receptor signaling." J Immunol 172(9): 5175-5184.

Shi, G. X., K. Harrison, et al. (2002). "RGS13 regulates germinal center B lymphocytes responsiveness to CXC chemokine ligand (CXCL)12 and CXCL13." J Immunol 169(5): 2507-2515.

Tofferi, J., S. Peng, et al. (2012). "C3b-Independent Complement Activation in Ischemia/Reperfusion Mesenteric Tissue Injury in Autoimmune Prone (B6. MRL/lpr) Mice." ISRN Immunology 2012.

Weeks, C., C. Moratz, et al. (2007). "Decay-accelerating factor attenuates remote ischemia-reperfusion-initiated organ damage." Clin Immunol 124(3): 311-327.