Howard J. Bryant, Ph.D.

Howard J. Bryant, Ph.D.

howard bryant

Name: Howard J. Bryant, Ph.D.

Department of Primary Appointment: Anatomy, Physiology & Genetics
Position: USU Faculty
Title: Associate Professor

Office Phone: (301) 295-3200

Profile

  • San Diego State College, 1963, 1965; University of Arizona, 1973

Regulation of Neuronal Excitability in the Amygdala Relevance to Epilepsy and Affective Disorders

Research in this laboratory is directed toward understanding the electrophysiology of the vascular smooth muscle membrane and its relation to the etiology of hypertension. In vivo and in vitro studies are carried out using animals with hypertension and their respective normotensive controls to better understand the role of smooth muscle electrophysiology in the development and maintenance of hypertension. In some experiments, animals are treated with antihypertensive agents to ameliorate the hypertension and the effects of these antihypertensive agents on the smooth muscle membrane are examined. Other areas of research include: 1) measurement of membrane potentials using a fiber optic system and voltage-sensitive dyes. 2) Measurement of electrophysiological and biophysical properties of cultured NG108 neuroblastoma cells. Several ionic currents in these cells are sensitive to the presence of chemical agents. We are currently characterizing these currents under various experimental conditions to determine if these electrophysiological changes may allow the cells to be used as biological sensors.