Mark C. Haigney, MD

Mark C. Haigney, MD

Mark Haigney

Name: Mark C. Haigney, MD

Department of Primary Appointment: Dept. of Medicine
Position: USU Faculty
Title: Professor of Medicine and Pharmacology, Director of Cardiology

Office Phone: (301) 295-3826
Fax Number: (301) 295-3557
Room: A3060


  • 1977-81 University of Virginia, Charlottesville, VA
  • 1983-7   Vanderbilt University School of Medicine, Nashville, TN


  • 1987-94 Johns Hopkins Hospital Internal Medicine, Cardiology, Electrophysiology

Clinical Practice

Staff Cardiologist and Electrophysiologist, Walter Reed National Military Medical Center


The USU Cardiovascular Laboratory is primarily concerned with identifying mechanisms of sudden cardiac death.  The lab combines basic and clinical investigations in a translational approach.  A tachycardia-pacing model of large animal heart failure has been in place for ten years and has allowed evaluation of specific ion channels and their alteration by heart failure.  The clinical research component has evaluated a number of approaches to prediction of arrhythmic events, with particular emphasis on unstable repolarization as manifest by QT interval variability. Dr. Haigney is particularly interested in iatrogenic factors contributing to sudden death, including the impact of prescription medications and supplements.

National Committees

American College of Cardiology, National Cardiovascular Data Registry on Implantable Defibrillator, committee member, Research and Publication Committee

Chair, American Heart Association (National) CardiacElectrophysiology- Clinical Peer Review Study Section

LV Pressure-Volume Loops in Control, HF Pigs


Selected Publications

  1. Wei SK, Ruknudin A, Hanlon SU, McCurley JM, Schulze D, Haigney MCP.  PKA hyperphosphorylation increases basal current but decreases β-adrenergic responsiveness of the sarcolemmal Na+/Ca2+ exchanger in failing pig myocytes. Circulation Research, 2003; 92: 897-903.
  2. Domanski M, Norman J, Pitt B, Haigney M, Hanlon S, Peyster E: Diuretic Use, Progressive Heart Failure, and Death In Patients in Studies of Left Ventricular Dysfunction (SOLVD). Journal of the American College of Cardiology, 2003;42:705-708.
  3. McCurley JM, Hanlon SU, Wei SK, Wedam EF, Michalski M, Haigney MC: Furosemide Accelerates the Progression of Left Ventricular Dysfunction in Experimental Heart Failure. J American College of Cardiology, 2004;44(6):1301-7.
  4. Haigney MC, Zareba W, Gentlesk P, Goldstein RE, Illovsky M, McNitt S, Moss A. QT Interval Variability and Spontaneous Ventricular Tachycardia or Fibrillation in MADIT II Patients. Journal of the American College of Cardiology, 2004; 44(7): 1481-1487.
  5. Wei SK, Ruknudin AM, Shou M, McCurley J, Hanlon SU, Elgin E, Schulze D, Haigney MC.  Muscarinic modulation of the sodium-calcium exchanger in heart failure.  Circulation.  2007;13;115(10):1225-33.
  6. Wedam EF, Bigelow G, Nuzzo P, Johnson RE, Haigney MC.  QT interval effects of methadone, levomethadyl acetate, and buprenorphine in a randomized trial. Archives of Internal Medicine, 2007;167(22):2469-75.
  7. Dobson, C, Olsen C, LaRovere MT, Bernardinangeli M, Veniani M, Midi P, Tavazzi L, Haigney M. QT Variability Index on 24-Hour Holter Independently Predicts Mortality  in Patients with Heart Failure: Analysis of GISSI-HF Trial Data. Heart Rhythm, 2011;8(8):1237-42.
  8. Goldstein RE, Haigney MC, Krone R, Mcnitt S, Zareba W, Moss AJ. Differing Effects of Cardiac Resynchronization Therapy on Long-term Mortality in Patient Subgroups of MADIT-CRT Defined by Baseline Conduction and One-Year Post-Treatment Left Ventricular Remodeling. Heart Rhythm. 2013;10(3):366-73.
  9. Dobson C, Kim A, Haigney M. QT Variability Index. Progress in Cardiovascular Disease, 2013; 56(2):186-94


    Yeung E, Krantz M, Schuller JL, Dale R, Haigney MC. Ranolazine for the Suppression of Ventricular Arrhythmia: A Case Series. Annals of Noninvasive Electrocardiography. 2014 19(4):345-50.
  11. H

    aigney M, Zareba W, La Rovere MT, Grasso I, Mortara D; GISSI HF M2Risk Investigators. Assessing the interaction of respiration and heart rate in heart failure and controls using ambulatory Holter recordings. 

    J Electrocardiol. 2014;47(6):831-5

For appointments, please contact my Administrative Assistant: Melisa Roderick-Thompson, (301) 295-3617