Xiaoming Zhou, PhD

Xiaoming Zhou, PhD

Name: Xiaoming Zhou, PhD

Department of Primary Appointment: Dept. of Medicine
Position: USU Faculty
Title: Research Associate Professor

Email: xiaoming.zhou@usuhs.edu (link sends e-mail)
Office Phone: (301) 295-9604
Lab Phone: (301) 295-1355
Fax Number: (301) 295-3557


Research: Regulation of the Transcription Factor NFAT5

Dr. Zhou’s laboratory is primarily focused on signaling regulation of NFAT5 in hypertonic stress and leishmaniasis. NFAT5 is the newest member of the Rel transcription factor family. It regulates a variety of biological functions. Its protective role against hypertonic stress and modulation of immune responses are the two areas which have been studied most. The kidney medulla is normally exposed to a hypertonic environment because of the urinary concentration mechanism. NFAT5 is essential for the kidney medulla to survive and function adequately.  NFAT5 may also protect against the pathogenic effects of parasites. like Leishmania. Over the past decade, more than a dozen of kinases have been identified that involve in tonicity-dependent activation of NFAT5 in cell culture. The opposite role of phosphatases has recently begun to reveal. Dr. Zhou’s laboratory is using cell and molecular approaches and mouse models to study how kinases and phosphatases regulate NFAT5 in the macrophages and kidney medulla from the normal mice and mice infected with Leishmania.

Recent Publications

  1. Zhou X, Ferraris JD, Dmitrieva NI, Liu Y, Burg MB. MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38a and p38d.  Proceedings of National Academy Sciences of USA 105:5620-5625, 2008.
  2. Zhou X, Gallazzini M, Burg MB, Ferraris JD. Contribution of SHP-1 protein tyrosine phosphatase to osmotic regulation of the transcription factor TonEBP/OREBP. Proceedings of National Academy Sciences of USA 107:7072-7077, 2010.
  3. Zhou X, Izumi Y, Burg MB, Ferraris JD. Rac1/osmosensing scaffold for MEKK3 contributes via phospholipase C-gamma1 to activation of the osmoprotective transcription factor NFAT5. Proceedings of National Academy Sciences of USA 108:12155-12160, 2011.
  4. Zhou X, Burg MB, Ferraris JD. Water restriction increases renal inner medullary manganese superoxide dismutase (MnSOD). American Journal of Physiology (Renal Physiology) 303:F674-F680, 2012.
  5. Zhou X, Wang H, Burg MB, Ferraris JD. Inhibitory phosphorylation of GSK-3b by AKT, PKA, and PI3K contributes to high NaCl-induced activation of the transcription factor NFAT5 (TonEBP/OREBP). American Journal of Physiology (Renal Physiology). 304:F908-F917, 2013.
  6. Topanurak S, Ferraris JD, Li J, Izumi Y, Williams C, Zhou X, Burg MB. High NaCl- and urea-induced post translational modifications that increase glycerophosphocholine by inhibiting GDPD5 phosphodiesterase. Proceedings of National Academy Sciences of USA. 110:7482-7487, 2013.
  7. Zhou X, Wang H, Burg MB, Ferraris JD. High NaCl-induced inhibition of PTG (protein targeting to glycogen) contributes to activation of NFAT5 through attenuation of the negative effect of SHP-1. American Journal of Physiology (Renal Physiology). 305:F362-F369, 2013.