|The TCR to NF-κB pathway. Following TCR activation, PKCθ is recruited to the immunological synapse. Activated PKCθ phosphorylates CARMA1, resulting in formation of the CARMA1, BCL10, MALT1 (CBM) complex. The CBM complex transmits activating signals that ultimately result in ubiquitination (U) and degradation of the NF-κB inhibitor, IκBα. NF-κB then translocates to the nucleus and activates transcription of genes required for T cell proliferation and differentiation.TCR-activated CD4 T cell with cytoplasmic Bcl10 POLKADOTS that co-localize with LC3+ autophagosomes. Bcl10 (green) and LC3 (red) signals combine to produce yellow at the region of overlap. Blue is cell surface anti-CD4. The fluorescence image is overlayed on a grayscale DIC image.|
Bioluminescence imaging of lyssavirus infection. Site and relative intensity of lyssavirus infection are visualized via a luminescence image overlaid on a CT scan. We are using this technology to longitudinally trace lyssavirus infection and to assess efficacy of novel therapies.
Research: Mechanisms of leukocyte activation in response to infectious agents and cancer
Our research is focused on investigating signaling events that regulate leukocyte activation. Although we have a longstanding interest in T cell receptor (TCR) activation of NF-κB, our work has more recently diversified to include studies of the innate response to a variety of pathogens and cancer. Our experimental approach combines cutting-edge imaging technologies with biochemistry, cell biology, and in vivo models of infection and tumorigenesis. We are currently focusing on the following major projects:
The mission of the Uniformed Services University of Health Sciences is to educate, train, and comprehensively prepare uniformed services health professionals, scientists, and leaders to support the Military and Public Health Systems, the National Security and National Defense Strategies of the United States, and the readiness of our Uniformed Services.
Since our first graduating class in 1982, the USU's MDs. Nurses and graduates in biomedical sciences provide exceptional service through service in the U.S. Military and civilian careers of distinction. Today, America's Medical School has 691 enrolled students and 5,043 graduates. Over 1,300 graduates in Biomedical Sciences lead aggressive research in medical research. Today's 663 graduates of the School of Nursing blend science, research and field training in advanced practice and PhD degrees. The USU's Postgraduate Dental College provides advanced degree's to the military's dental community, graduating 72 students since establishment.
Research At USU
The University's research program covers a range of clinical and other topics important to both the military and public health. Infectious diseases, trauma medicine, health maintenance, and cancer are areas of particular strength. Researchers are also making important new efforts in state-of-the-art fields that cut across disciplines, such as genomics, proteomics, and drug-delivery mechanisms.
USU is home to many different Centers and Institutes, which help advance the university's research, education and public service missions. Faculty members and students collaborate with other leading experts at USU's Centers and Institutes on projects that push incredible boundaries across manifold disciplines of biomedical science. Their work is shaping military medicine and world health in many positive, powerful ways.
Military At USU
The USU's military unique curriculum is supported by military professions from all services who teach USU's military and civilian students. All military personnel are supported by the USU Brigade, the Brigade staff are managed by the Military Personnel Office.
AFRRI At USU
AFRRI mission is to preserve the health and performance of U.S. military personnel and to protect humankind through research that advances understanding of the effects of ionizing radiation.
To these ends, the institute collaboratively researches the biological effects of ionizing radiation and provides medical training and emergency response to manage incidents related to radiation exposure.