Chou-Zen Giam, Ph.D.
Chou-Zen Giam, Ph.D.

Name: Chou-Zen Giam, Ph.D.
Research Interests:
The molecular biology and pathogenesis of human retroviruses and viral oncogenesis. How chronic NF-kB activation promotes genomic instability and cellular senescence.
Education
Ph. D. Molecular Biology and Biochemistry, University of Connecticut Health Center, Farmington, CT, USA (05/1983)
Post-doctoral Fellow, Laboratory of Molecular Virology, NCI, NIH, Bethesda, MD, USA (09/1987)
Biography
Bibliography
- NF-kB signaling mechanisms in HTLV-1-induced adult T-cell leukemia/lymphoma. Harhaj EW, Giam CZ, FEBS J. 2018. doi: 10.1111/febs.14492.
- HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma-A Tale of Two Proteins: Tax and HBZ. Giam CZ, Semmes OJ. Viruses. 2016 Jun 16;8(6). pii: E161. https://www.ncbi.nlm.nih.gov/pubmed/27322308
- HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation. Ho YK, Zhi H, Bowlin T, Dorjbal B, Philip S, Zahoor MA, Shih HM, Semmes OJ, Schaefer B, Glover JN, Giam CZ. PLoS Pathog. 2015 Aug 18;11(8):e1005102. https://www.ncbi.nlm.nih.gov/pubmed/26285145
- KSHV vCyclin counters the senescence/G1 arrest response triggered by NF-kB hyperactivation. Zhi H, Zahoor MA, Shudofsky AM, Giam CZ. Oncogene. 2015; 34(4):496-505. NIHMSID: NIHMS550287 https://www.ncbi.nlm.nih.gov/pubmed/24469036
- HTLV-1 tax-induced rapid senescence is driven by the transcriptional activity of NF-kB and depends on chronically activated IKKa and p65/RelA. Ho YK, Zhi H, DeBiaso D, Philip S, Shih HM, Giam CZ. Journal of Virology. 2012; 86(17):9474-83. https://www.ncbi.nlm.nih.gov/pubmed/22740410
- Complex cell cycle abnormalities caused by human T-lymphotropic virus type 1 Tax. Yang L, Kotomura N, Ho YK, Zhi H, Bixler S, Schell MJ, Giam CZ. Journal of Virology. 2011; 85(6):3001-9.
- NF-kB hyper-activation by HTLV-1 tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ. Zhi H, Yang L, Kuo YL, Ho YK, Shih HM, Giam CZ. PLoS pathogens. 2011; 7(4):e1002025. https://www.ncbi.nlm.nih.gov/pubmed/21552325
- Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence. Kuo YL, Giam CZ. The EMBO journal. 2006; 25(8):1741-52. https://www.ncbi.nlm.nih.gov/pubmed/16601696
- Published video: https://www.youtube.com/watch?v=votp2hRndIk&spfreload=10
- Published video: https://www.youtube.com/watch?v=XasVBcMRGls&spfreload=10