Diego Iacono, M.D., Ph.D.
Diego Iacono, M.D., Ph.D.
Name: Diego Iacono, M.D., Ph.D.
Traumatic brain injury (TBI), TBI-related Neuropsychiatric disorders, Dementias, Movement Disorders, Clinical Trials
Animal modeling, Molecular mechanisms, Drug Discovery
In 2016, on the behalf of the Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF), Dr. Iacono joined the Center for Neuroscience and Regenerative Medicine (CNRM) at the Uniformed Services University (USU), Bethesda, MD as Research Associate Professor, where he was also appointed Deputy Director of the Brain Tissue Repository (BTR) and Neuropathology Core. In 2017 he obtained a Faculty appointment at USU as Associate Professor in the Departments of Neurology and Pathology (Neuropathology).
As Deputy Director of BTR and Neuropathology Core at CNRM-USU, Dr. Iacono is contributing to establishing and expanding the first brain bank and neuropathology research center in the world fully dedicated to the study of TBI and TBI-related neuropsychiatric consequences in military personnel. One of the main goals of Dr. Iacono's research is to investigate short- and long-term effects on the brain of TBI, and correlate TBI with their related neuropsychiatric sequelae in military personnel. In addition, Dr. Iacono is expanding his clinical and experimental research activities collaborating and initiating multiple collaborative grant-funded studies that include imaging-genetic-pathologic correlations in subjects with a history of single-TBI, repetitive-TBI and TBI-related neurodegenerative diseases with a special emphasis on neuropsychiatric-neuropathological correlates. Dr. Iacono has recently established his own translational neuropathology lab to perform more basic research investigations using human tissues, rodents and other animal models (e.g. ferret, swine). His research activities aim to identify precise molecular aspects, pathophysiological mechanisms, and timing of TBI and TBI-related conditions (including dementias, movement disorders, and epilepsy).
In 2017, Dr. Iacono has been appointed Research Collaborator at the Neurodegenerative Clinics, NINDS, NIH, Bethesda, MD, where he will collaborate to different clinical research studies evaluating subjects with various types of neurodegenerative conditions, in particular subjects with a diagnosis of FTD, ALS-FTD, PD and DLB and history of TBI.
Representative publications, projects, and/or deployments
- MRI-Neuropathology Correlations (USU-Harvard University-Mount Sinai Icahn School of Medicine project; USU-CNRM-NIH MRI histology project)
- RepetitiveTBI (CNRM Brain collection), BlastTBI (CNRM brain collection), Post Traumatic Stress Disorder (PTSD) (CNRM brain collection and USU-CNRM-Duke collaboration)
- CTE and Co-occurring Brain Pathologies; Quantitative Neuropathology (Neurostereology)
- TBI and Neurodegeneration (Early-onset dementias, parkinsonisms, FTD, ALS)
- Tau pathology mechanisms and therapeutics (USU-UCSF)
- Guam disease (3-diseases with a common cause project), Department of Pathology, USU Guam Brain collection
- Twin Brains Study