Joseph Mattapallil, B.V.Sc., M.S., Ph.D.

Joseph J. Mattapallil, B.V.Sc., M.S., Ph.D.

Name: Joseph J. Mattapallil, B.V.Sc., M.S., Ph.D.

USU Department of Primary Appointment: 
Microbiology and Immunology
Co-Director of Bench to Bedside and Beyond (BBB) Module and Graduate Molecular Virology (MCO501)
Faculty Rank: 
Associate Professor
Uniformed Services University of the Health Sciences, Bethesda, MD

Research Interests:
Basic Biology of Bacterial, Viral, or Parasite Diseases
Immunology, Host Defenses

Office Phone: 
(301) 295-3737


1997: Ph.D., Immunology, University of California Davis, Davis, CA
1994: M.S., Animal Science, University of California Davis, Davis, CA
1986: B.V.Sc, Veterinary Medicine, College of Veterinary Medicine, APAU, India

Representative publications, projects, and/or deployments

  • Standing/Chartered Member, AIDS Immunology and Pathogenesis (AIP) Study Section, Center for Scientific Review, NIH (2014 – 2020)
  • Member, DAIT, NIAID Radiation-Nuclear Countermeasures Program Data and Safety Monitoring Committee (RNMC-DSMB), 2011 – 2014
  • Member, Over 25 NIH Special Emphasis Panels reviewing AIDS, and Biodefense related grant applications, 2006 – Present
  • Associate Editor, Journal of Immunolgy (2013 - present)
  • Academic Editor, Plos One (2013 - present)
  • Associate Editor, Cellular Immunology (2015 - present)
  • Editorial Board Member, Clinical and Vaccine Immunology (2012 - present)
  • Editorial Board Member, AIDS Research and Human Retroviruses (2012 - present)
  • Ad Hoc Reviewer, Journal of Clinical Investigation, Journal of Infectious Diseases, Mucosal Immunology, Plos Pathogens, FASEB Journal, Blood, Retrovirology, Journal of Virology


  • Mattapallil, J., Douek, D. C., Hill, B., Nishimura, Y., Martin, M. A and Roederer, M. 2005. Massive infection and loss of memory CD4 T-cells in multiple tissues during acute SIV Infection. Nature. 434: 1093-97.
  • Mattapallil, J., Douek, D.C., Buckler-White, A., Montefiori, D., Letvin, N. L., Nabel, G. J and Roederer, M. 2006. Vaccination prevents the destruction of CD4 memory T cells during acute SIV infection. J. Exp. Med. 203: 1533-41.
  • Kader, M., Hassan, W., Eberly, M., Piatak, M., Lifson, J., Roederer, M and Mattapallil, J. J. 2008. Anti-retroviral therapy prior to acute viral replication preserves CD4 T cells in the periphery but not in the rectal mucosa during acute simian immunodeficiency virus infection. J. Virol. 82: 11467-71.
  • Eberly, M. D., Kader, M., Hassan, W., Rogers, K. A., Zhou, J., Mueller, Y.M., Mattapallil, M. J., Piatak, M., Lifson, J. D., Katsikis, P. D., Roederer, M., Villinger, F and Mattapallil, J.J. 2009. Increased IL-15 production is associated with higher susceptibility of memory CD4 T cells to SIV during acute infection. J. Immunology. 182: 1439-48.
  • Kader, M., Wang, X., Piatak, M., Lifson, J., Roederer, M., Veazy, R and Mattapallil, J. J. 2009. a4+β7hiCD4+ memory T cells harbor most Th-17 cells and are preferentially infected during acute SIV infection. Mucosal Immunology: 2: 439-49.
  • Moore, A. C., Bixler, S. L., Lewis, M. G., Verthelyi, D and Mattapallil, J. 2012. Mucosal and Peripheral Lin–HLA-DR+CD11c/123–CD14– Mononuclear cells are preferentially infected very early during simian immunodeficiency virus infection. J Virology: 86: 1069-78.
  • Bixler, S., Sandler, N., Douek, D. C. and Mattapallil, J. 2013. Suppressed Th17 levels correlate with elevated PIAS3, SHP2, and SOCS3 Expression in CD4 T cells during acute simian immunodeficiency virus infection. J. Virology: 87: 7093-101.
  • Onabajo, O. O., George, J., Lewis, M. and Mattapallil, J. 2013. Rhesus macaque lymph node PD-1hiCD4+ T cells express high levels of CXCR5 and IL-21 and display a CCR7loICOS+Bcl6+ T follicular (Tfh) cell phenotype. Plos One: 8(3):e59758.
  • George, J., Lewis, M. G., Renne, R and Mattapallil, J. 2015. Suppression of transforming growth factor b receptor 2 and smad5 is associated with high levels of microRNA miR-155 in the oral mucosa during chronic simian immunodeficiency virus infection. J. Virology: 89: 2972-8.
  • George, J., Renn L., Lewis, M. G., Verthelyi, D., Roederer, M., Rabin, R. L. and Mattapallil, J. 2016. Early treatment with reverse transcriptase inhibitors significantly suppresses peak plasma IFNα in vivo during acute simian immunodeficiency virus infection. Cellular Immunology: 310:156-164.