Mark Haigney, MD

Mark C. Haigney, MD

Name: Mark C. Haigney, MD

USU Department of Primary Appointment: 
Medicine
Title: 
Director of Cardiology
Faculty Rank: 
Full Professor
Location: 
Uniformed Services University of the Health Sciences, Bethesda, MD

Research Interests:
Sudden Cardiac Death in the Young
Cardiac Repolarization

Office Phone: 
(301) 295-3826

Education

BA: University of Virginia, Charlottesville, VA
MD: Vanderbilt University School of Medicine, Nashville, TN
Post-doctoral training: Johns Hopkins Hospital, Baltimore, MD

Biography

Dr. Haigney is a board certified cardiologist and electrophysiologist who attends in the Walter Reed Cardiology and Genetic Cardiology clinics. The Haigney Cardiovascular Laboratory is primarily concerned with identifying mechanisms of sudden cardiac death, including those related to genetically transmitted arrhythmia syndromes. The lab combines basic and clinical investigations in a translational approach. A tachycardia-pacing model of large animal heart failure has been in place for ten years and has allowed evaluation of specific ion channels and their alteration by heart failure. The clinical research component has evaluated a number of approaches to prediction of arrhythmic events, with particular emphasis on unstable repolarization as manifest by QT interval variability. Most recently, the laboratory has investigated the use of inducible pluripotent stem cell derived myocytes to understand the mechanisms of cardiac arrest in human subjects. Dr. Haigney is particularly interested in iatrogenic factors contributing to sudden death, including the impact of prescription medications, particularly synthetic opioids, and sympathomimetic supplements.

CONTACT INFORMATION
Office A3060, Hebert School of Medicine, 4301 Jones Bridge Road, Bethesda MD 20814
Phone: 301-295-3826
Fax: 301-295-3557
For appointments, please contact my Administrative Assistant: 301-295-3617
For appointments in the Genetic Cardiology Clinic at Walter Reed, please call 301-295-4939

Representative publications, projects, and/or deployments

  • 2013 Carol Johns Medal for Service, Uniformed Services University
  • 2016 Civilian Educator of the Year, School of Medicine, Uniformed Services University
  • 2014- 2018 Treasurer, International Society for Holter and Noninvasive Electrocardiology
  • 2015-6 Chair, National American Heart Association Cardiac Electrophysiology- Clinical Peer Review Study Group,
  • 2013--7 American College of Cardiology, National Cardiovascular Data Registry on Implantable Defibrillator, Research and Publication Committee
  • DSMB Member MADIT RIT, MADT CHIC, JAVA CRT, WR1877, WR1849

Bibliography

  • Klein MG, Shou M, Stohlman J, Solhjoo S, Haigney M, Tidwell RR, Goldstein RE, Flagg TP, Haigney MC. Role of suppression of the inward rectifier current in terminal action potential repolarization in the failing heart. Heart Rhythm. 2017. PMID: 28396172
  • Lin Y, Linask KL, Mallon B, Johnson K, Klein M, Beers J, Xie W, Du Y, Liu C, Lai Y, Zou J, Haigney M, Yang H, Rao M, Chen G. Heparin Promotes Cardiac Differentiation of Human Pluripotent Stem Cells in Chemically Defined Albumin-Free Medium, Enabling Consistent Manufacture of Cardiomyocytes. Stem Cells Transl Med. 2017 Feb;6(2):527-538. PMID: 28191759
  • Sandhu A, David Kao, Philip S. Mehler, Mark CP Haigney, Krantz MJ. Cardiovascular Disorders Associated with Naloxone Monotherapy and in Fixed-Dose Combination with Opioids: Data from International Safety Surveillance. Int J Cardiol. 2016 ;212:360-3
  • Fatima N, Devin C. Cohen, Gauthaman Sukumar, Tristan M. Sissung, James F. Schooley, Jr., Mark C. Haigney, William C. Claycomb, Rachel T. Cox, Clifton L. Dalgard, Susan E. Bates, and Thomas P. Flagg. Histone deacetylase inhibitors modulate KATP subunit transcription in HL-1 cardiomyocytes through effects on cholesterol homeostasis. Frontiers in Pharmacology 2015 6 1-9.
  • Kao D, Haigney M, Mehler P, Krantz M. Arrhythmia Associated with Buprenorphine and Methadone Reported to the Food and Drug Administration. Addiction 2015 Sep;110(9):1468-75.
  • Haigney MC. Looking for Virtuous Promiscuity: Electrocardiographic Evidence of Multichannel Drug Block. Clinical Pharm and Therapeutics, 2014 ;96(5):534-6. doi: 10.1038/clpt.2014.165. PMID: 25336265
  • Mark Haigney, Wojceich Zareba, Maria Teresa La Rovere, Ian Grasso, David Mortara. Assessing the Interaction of Respiration and Heart Rate in Heart Failure and Controls Using Ambulatory Holter Recordings. J ECG, in press. PMID: 25172186
  • Chou R, Inturisi C, Feillin D, Haigney M, Walsh S. Methadone Safety: A Clinical Practice Guideline from the American Pain Society and College on Problems of Drug Dependence. J Pain. 2014;15(4):321-37.
  • Goldstein RE, Haigney MC, Krone R, Mcnitt S, Zareba W, Moss AJ. Differing Effects of Cardiac Resynchronization Therapy on Long-term Mortality in Patient Subgroups of MADIT-CRT Defined by Baseline Conduction and One-Year Post-Treatment Left Ventricular Remodeling. Heart Rhythm. 2013 Mar;10(3):366-73.
  • 48. Dobson, C, Olsen C, LaRovere MT, Bernardinangeli M, Veniani M, Midi P, Tavazzi L, Haigney M. QT Variability Index on 24-Hour Holter Independently Predicts Mortality in Patients with Heart Failure: Analysis of GISSI-HF Trial Data. Heart Rhythm, 2011;8(8):1237-42.