Shuishu Wang, Ph.D.

Shuishu Wang, Ph.D.

Name: Shuishu Wang, Ph.D.

USU Department of Primary Appointment: 
Faculty Rank: 
Assistant Professor
Uniformed Services University of the Health Sciences, Bethesda, MD
Office Phone: 
(301) 295-3418


Ph.D., Purdue University
Postdoctoral, UCLA

Representative publications, projects, and/or deployments

  • 2008 – pres. Assistant Professor, Department of Biochemistry and Molecular Biology, F. Edward Hebert School of Medicine, Uniformed Services University, Bethesda, Maryland.
  • 2004 – 2008 Assistant Member, Public Health Research Institute, Newark, New Jersey.
  • 2006 – 2008 Assistant Professor, Department of Biochemistry and Molecular Biology, New Jersey Medical School, Newark, New Jersey.
  • National Institute of General Medical Sciences, R01GM079185, Structural and functional studies of a PhoP-PhoR two-component system, 7/20/2007 – 5/31/2012, no cost extension to 5/31/2015, total costs for the entire grant period $1,400,490, role PI.
  • USUHS intramural exploratory grant, Bio-71-3018, Mechanisms of a PhoPR signaling system from Mycobacterium tuberculosis, 2/2015 – 9/2017, $150,000 direct costs + $71,765 indirect costs, role PI.
  • USUHS intramural bridge funding award. Phosphorylation and signaling mechanism of the PhoPR two-component system, 4/2017 – 4/2018, $50,000 direct costs + $25,000 indirect costs, role PI.


  • 1. L. Wang, D. Xing, A. Le Van, A.E. Jerse, and S. Wang. Structure-based design of ferritin-nanoparticle immunogens displaying antigenic loops of Neisseria gonorrhoeae. FEBS Open Bio (2017) 7, 1196-1207.
  • 2. D. Xing, M.B. Ryndak, L.Wang, I. Kolesnikova, I. Smith, and S. Wang. Asymmetric structure of the dimerization domain of PhoR, a sensor kinase important for the virulence of Mycobacterium tuberculosis. ACS Omega (2017) 2, 3509-17.
  • 3. L. Wang, M. Xu, N. Southall, W. Zheng, and S. Wang. A High-Throughput Assay for Developing Inhibitors of PhoP, A Virulence Factor of Mycobacterium tuberculosis. Comb Chem High Throughput Screen. (2016) 19, 855-864.
  • 4. X. He, L. Wang, and S. Wang. Structural basis of DNA sequence recognition by the response regulator PhoP in Mycobacterium tuberculosis. Sci Rep. (2016) 6, 24442.
  • 5. X. He and S. Wang. DNA Consensus Sequence Motif for Binding Response Regulator PhoP, a Virulence Regulator of Mycobacterium tuberculosis. Biochemistry (2014) 53, 8008-20.
  • 6. N. Sambuughin, X. Liu, S. Bijarnia, T. Wallace, I.C. Verma, S. Hamilton, S. Muldoon, L.J. Tallon and S. Wang. Exome sequencing reveals SCO2 mutations in a family presented with fatal infantile hyperthermia. J. Hum. Genet. (2013) 58, 226-8.
  • 7. S. Wang. Bacterial Two-Component Systems: Structures and Signaling Mechanisms, in Protein Phosphorylation in Human Health, p439-466, (2012), C. Huang (Ed.), ISBN: 978-953-51-0737-8, InTech, DOI: 10.5772/48277.
  • 8. S. Menon and S. Wang. Structure of the response regulator PhoP from Mycobacterium tuberculosis reveals a dimer through the receiver domain. Biochemistry (2011) 50, 5948-5957.
  • 9. M. B. Ryndak, S. Wang, I. Smith, and G. M. Rodriguez. The Mycobacterium tuberculosis high-affinity iron importer, IrtA, contains an FAD-binding Domain. J. Bacteriol. (2010) 192, 861-869.
  • 10. M. Ryndak, S. Wang, and I. Smith. PhoP, a key player in Mycobacterium tuberculosis virulence. Trends in Microbiology (2008) 16, 528-534.