Thomas Darling, M.D. Ph.D.

Thomas N Darling, M.D. Ph.D.

Name: Thomas N Darling, M.D. Ph.D.

USU Department of Primary Appointment: 
Dermatology
Title: 
Chair
Faculty Rank: 
Full Professor
Location: 
Uniformed Services University of the Health Sciences, Bethesda, MD

Research Interests:
Skin tumors
Skin regeneration

Office Phone: 
(301) 295-3528

Education

1979-1983 B.S. in Biology, Houghton College, Houghton, NY
1983-1990 M.D.-Ph.D., Duke University School of Medicine, Duke University Graduate School, Department of Cell Biology, Durham, NC,
1990-1991 Medicine Internship, UNC Hospitals, Chapel Hill, NC
1991-1994 Dermatology Residency, Duke University Medical Center, Durham, NC
1994-1996 Clinical Associate, Dermatology Branch, NIH, Bethesda, MD
1996-1998 Clinical Fellow, Dermatology Branch, NIH, Bethesda, MD

Representative publications, projects, and/or deployments

  • 1999-2005 Assistant Professor of Dermatology, Assistant Professor of Anatomy Physiology and Genetics (secondary), Uniformed Services University of the Health Sciences
  • 2005-2012 Associate Professor of Dermatology, (tenured 2005) Associate Professor of Anatomy Physiology and Genetics (secondary), Associate Professor of Molecular and Cell Biology (secondary), Uniformed Services University of the Health Sciences
  • 2012-present Professor of Dermatology Professor of Anatomy Physiology and Genetics (secondary), Professor of Molecular and Cell Biology (secondary), Uniformed Services University of the Health Sciences
  • 2014-present Chair of Dermatology Uniformed Services University of the Health Sciences, Bethesda, MD
  • 1994-1998 United States Public Health Service, Research Officer Group, 0-3 (LT) Sr. Assistant Surgeon, promoted to Permanent Grade: 0-4 (LT Commander) Surgeon, Bethesda, MD
  • 2009 James Leonard Award for Excellence in Clinical Research, USUHS
  • 2012 Member of research team that received a National Human Genome Research Institute GREAT Award, for “Discovery of the cause of Proteus syndrome”
  • 2013 Member, American Dermatological Association
  • 2013 Member of research team that received a National Human Genome Research Institute GREAT Award, for “Defining a new class of human disease caused by somatic mutations in the PI3K-AKT1 pathway”
  • 2016 Member of research team to receive a NHLBI Orloff Science Award for studies of circulating tumor cells in patients with LAM and TSC

Bibliography

  • Klover PJ, Thangapazham RL, Kato J, Wang JA, Anderson SA, Hoffmann V, Steagall WK, Li S, McCart E, Nathan N, Bernstock JD, Wilkerson MD, Dalgard CL, Moss J, Darling TN. Tsc2 disruption in mesenchymal progenitors results in tumors with vascular anomalies overexpressing Lgals3. Elife. 2017;6. pii: e23202. PMID: 28695825
  • Bongiorno MA, Nathan N, Oyerinde O, Wang JA, Lee CR, Brown GT, Moss J, Darling TN. Clinical Characteristics of Connective Tissue Nevi in Tuberous Sclerosis Complex With Special Emphasis on Shagreen Patches. JAMA Dermatol. 2017;153(7):660-665. PMID:
  • Cao J, Tyburczy ME, Moss J, Darling TN, Widlund HR, Kwiatkowski DJ. Tuberous sclerosis complex inactivation disrupts melanogenesis via mTORC1 activation. J Clin Invest. 2017;127:349-364. PMID: 27918305
  • Nathan N, Burke K, Moss J, Darling TN. A diagnostic and management algorithm for individuals with an isolated skin finding suggestive of tuberous sclerosis complex. Br J Dermatol. 2017;176(1):220-223. PMID: 27167640
  • Nathan N, Tyburczy ME, Hamieh L, Wang JA, Brown GT, Richard Lee CC, Kwiatkowski DJ, Moss J, Darling TN. Nipple Angiofibromas with Loss of TSC2 Are Associated with Tuberous Sclerosis Complex. J Invest Dermatol. 2016;136(2):535-8. PMID: 26824744
  • Nathan N, Burke K, Trickett C, Moss J, Darling TN. The Adult Phenotype of Tuberous Sclerosis Complex in Men. Acta Derm Venereol. 2016;96(2):278-80. PMID: 26258325
  • Nathan N, Wang JA, Li S, Cowen EW, Haughey M, Moss J, Darling TN. Improvement of tuberous sclerosis complex (TSC) skin tumors during long-term treatment with oral sirolimus. J Am Acad Dermatol. 2015;73:802-8. PMID: 26365597
  • Teng JM, Cowen EW, Wataya-Kaneda M, Gosnell ES, Witman PM, Hebert AA, Mlynarczyk G, Soltani K, Darling TN. Dermatologic and dental aspects of the 2012 international tuberous sclerosis complex consensus statements. JAMA Dermatol. 2014;150:1095-101. PMID: 25029267
  • Thangapazham RL, Klover P, Li S, Wang JA, Sperling L, Darling TN. A model system to analyze the ability of human keratinocytes to form hair follicles. Exp Dermatol. 2014;23:443-6. PMID: 24758480
  • Tyburczy ME, Wang JA, Li S, Thangapazham R, Chekaluk Y, Moss J, Kwiatkowski DJ, Darling TN. Sun exposure causes somatic second-hit mutations and angiofibroma development in tuberous sclerosis complex. Hum Mol Genet. 2014;23:2023-9. PMID: 24271014