Thomas Davis, PhD
Thomas A Davis, PhD
Name: Thomas A Davis, PhD
Traumatic Injury, wound healing, allotransplantation, tissue regeneration, tolerance induction
1987 M.S. George Mason University, Fairfax, VA
1983 B.S. George Mason University, Fairfax, VA
Dr. Davis, Professor and Vice Chair of Research in the Department of Surgery, joined USU in February 2017. Dr. Davis has spent over 35 years in the areas of immune modulation, immunotherapy, radiation injury, stem cell research, experimental hematology, wound healing and transplantation biology. He has published 94 peer-reviewed manuscripts and 7 book chapters. Before joining USU, Dr. Davis served as the Scientific Director of the Regenerative Medicine Department at the Naval Medical Research and lead multifaceted programs that explore the events that govern the development, patterning, immune modulation and healing/repair/ regeneration of cells and organs following traumatic injury. The main areas of research focused on rapidly and effectively developing new therapies to address urgent questions in the areas of limb salvage and tissue regeneration, burn injury, scar prevention, heterotopic ossification development, allograft organ transplantation and radiation injury countermeasures. Previously, Dr. Davis was the Scientific Director of Endogeny Bio a small start up biopharmaceutical company developing a new class of protein and small molecule therapeutics that treat and repair diseased tissue by targeting pools of endogenous tissue multipotent stem/progenitor cells that can be recruited to a site of injury/tissue damage. Prior, Dr. Davis was Director of Large Scale Biology Corporation’s Immunology and Stem Cell Biology Programs where he was responsible for cytokine/growth factor discovery and immune cell-based proteomic initiatives. From 1997 to 1999, he served as the Director of Immunology R&D Program Initiatives at Nextran Inc. that focused on solid organ xenotransplantation immunology and efficacy evaluation of various immunotherapeutic applications to facilitate engraftment and tolerance induction in nonhuman xenogeneic preclinical models. From 1981-1997as a Post Doc and then Staff Scientist, Dr. Davis led scientific teams at the Armed Forces Radiobiology Research Institute evaluating the efficacy of newly cloned recombinant molecules/ cytokines/hematopoietic growth factors as well as novel radioprotective countermeasures on enhancing survival and recovery of hematopoiesis in lethally irradiated small and large animal models. Dr. Davis played a key role in demonstrating the efficacy of Neupogen (G-CSF) in pivotal bone marrow myeloablative studies conducted in non-human primates, approved by FDA's Biological Response Modifiers Advisory Committee, as the first stock-piled growth factor for use as an antidote to chemical weapon exposure by military field hospitals during the Persian Gulf War. In 1995, Dr. Davis was invited and received funding support from NASA to develop and deploy an fully automated self-contained bioreactor to evaluate the effects of prolonged space flight on the ex vivo growth and expansion of human bone marrow hematopoietic stem cells (space shuttle missions STS-63 (Discovery) and STS-69 (Endeavour)). Dr. Davis received his Ph.D. in Immunology from George Washington University in 1993.
Representative publications, projects, and/or deployments
- 2017-present Deputy Vice Chair of Research, Department of Surgery Uniformed Services University of Health Sciences-WRNMMC, Bethesda, MD
- 2013-present Professor, Department of Surgery, Uniformed Services University of Health Sciences,
- 2003-2017 Scientific Director, Regenerative Medicine Department, Naval Medical Research Center, The Jackson Foundation for the Advancement of Military Medicine
- 2002-2003 Scientific Director, Endogeny Bio Corp, Rockville, MD
- 1999-2002 Director, Immunology and Stem Cell Biology Department, Large Scale Biology, Vacaville, CA
- 1997-1999 Director, Immunology Department, Nextran, Inc., Princeton, NJ.
- 1994-1997 Assistant Professor of Medicine, Uniformed University of Health Services, Bethesda, MD.
- 1993-1997 Head, Stem Cell Biology Branch, Naval Medical Research Institute, Bethesda, MD.
- 1985-1990 Research Immunologist, Naval Medical Research Institute, Bethesda, MD.
- 1981-1985 Research Associate, Armed Forces Radiobiology Research Institute, Bethesda, MD.