Thomas Flagg, PhD

Thomas P. Flagg, PhD

Name: Thomas P. Flagg, PhD

USU Department of Primary Appointment: 
Anatomy, Physiology and Genetics
Faculty Rank: 
Associate Professor
Uniformed Services University of the Health Sciences, Bethesda, MD

Research Interests:
Ion Channel Structure & Function
Co-Module Director, Foundation in Medicine Module

Office Phone: 
(301) 295-3509


B.S. Stevens Institute of Technology, Hoboken, NJ Major: Chemical Biology; Minor: History 1989 – 1993
M.S. University of Maryland, Baltimore, MD Major: Physiology 1994 – 1996
Ph.D. University of Maryland, Baltimore, MD Major: Physiology 1996 – 2001
Mentor: Paul A. Welling, M.D.
Postdoctoral Washington University School of Medicine, St. Louis, MO 2001 - 2004
Mentor: Colin G. Nichols, Ph.D.


  • Geiger RM, MG Klein, N Fatima, RE Goldstein, MJ Krantz, MC Haigney, and TP Flagg. Rapid Assessment of Proarrhythmic Potential Using Human iPSC-Derived Cardiomyocytes. JACC Clin Electrophysiol, in press, 2020.
  • Khayrullina G, Moritz KE, Schooley JF, Fatima N, Viollet C, McCormack NM, Smyth JT, Doughty ML, Dalgard CL, Flagg TP, Burnett BG. SMN-deficiency disrupts SERCA2 expression and intracellular Ca2+ signaling in cardiomyocytes from SMA mice and patient-derived iPSCs. Skelet Muscle.10:16, 2020.
  • Krantz MJ, Flagg TP, Haigney MCP. Dangerous Needle Stick. Circulation. 141:1424-1426, 2020.
  • Goldstein RE, Klein MG, Ouimet SP, Shou M, Hood MN, Flagg TP, Haigney MC. Hemodynamic Effects of Late Sodium Current Inhibitors in a Swine Model of Heart Failure. J Card Fail. 25:828-836, 2019.
  • Flagg, TP, SW Rothwell, and BE Neubauer. Avoiding the chopping block in curricular reform - re-imagining physiology laboratories in the era of integrated medical curricula. Adv Physiol Educ, 41: 279-285, 2017.
  • Klein, MG, M Shou, J Stohlman, M Haigney, RR Tidwell, TP Flagg, RE Goldstein, MC Haigney. Role of IK1 Suppression on Terminal Action Potential Repolarization in the Failing Heart. Heart Rhythm, 14:1217-1223, 2017.
  • Klein, MG, MC Haigney, PS Mehler, N Fatima, TP Flagg, and MJ Krantz. Potent Inhibition of hERG Channels by the Over-The Counter Anti-Diarrheal Agent Loperamide, JACC Clin Electrophysiol, 251, 2016.
  • Fatima, N, DC Cohen, JF Schooley, Jr., MC Haigney, WC Claycomb, CL Dalgard, RT Cox, SE Bates, and TP Flagg. Histone deacetylase inhibitors modulate KATP subunit transcription in HL-1 cardiomyocytes through effects on cholesterol. Frontiers Pharmacol, 6:168, 2015.
  • Schooley, Jr., JF, AMA Namboodiri, RT Cox, R Bunger, and TP Flagg. Acetate Transiently Inhibits Myocardial Contraction by Increasing Mitochondrial Calcium Uptake. BMC Physiol,14:12, 2014.
  • Fatima, N., JF Schooley, Jr., WC Claycomb, and TP Flagg. Promoter DNA methylation regulates murine SUR1 (Abcc8) and SUR2 (Abcc9) expression in HL-1 cardiomyocytes. PlosOne, 7: e41533, 2012.