Xin Xiang, Ph. D.

Xin Xiang, Ph. D.

Name: Xin Xiang, Ph. D.

USU Department of Primary Appointment: 
Biochemistry
Title: 
Professor
Faculty Rank: 
Professor
Location: 
Uniformed Services University of the Health Sciences, Bethesda, MD

Research Interests:
Cell biology, intracellular transport, motor proteins
Genetics, fungi, Aspergillus nidulans

Office Phone: 
(301) 295-0000

Education

B.S. & M.S. Department of Biology, Peking University, Beijing, P. R. China
Ph.D. Department of Biochemistry, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey. Advisor: Dr. Kiran Chada.
Post-doctoral research: Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey. Advisor: Dr. Ron Morris.

Biography

2012- Professor, Department of Biochemistry and Molecular Biology, the Uniformed Services University of the Health Sciences-F. Edward Hébert School of Medicine
2004-2012 Associate Professor, Department of Biochemistry and Molecular Biology, the Uniformed Services University of the Health Sciences-F. Edward Hébert School of Medicine
1999-2004 Assistant professor, Department of Biochemistry and Molecular Biology, the Uniformed Services University of the Health Sciences-F. Edward Hébert School of Medicine


Representative publications, projects, and/or deployments

  • Xiang, X. and Qiu, R. (2020) Cargo-mediated activation of cytoplasmic dynein in vivo (review). Frontiers in Cell and Developmental Biology 23 October 2020 | https://doi.org/10.3389/fcell.2020.598952 (Research Topic: Energy Requirements in Membrane Trafficking. Editor: C.M. Guardia)
  • Xiang, X. (2018) Insights into Cytoplasmic Dynein Function and Regulation from Fungal Genetics (book chapter), in: S. M. King (Ed.) Dyneins: Structure, Biology and Disease: The Biology of Dynein Motors, vol. 1, Academic Press, Elsevier, 2018, pp. 470-501.
  • Xiang, X. (2018) Nuclear Movement in fungi (review). Seminars in Cell and Developmental Biology: in the special issue "Nuclear positioning" (Guest Editor: B. Cadot), 82:3-16.
  • Xiang, X, Qiu, R., Yao, X., Arst, H.N. Jr, Peñalva, M.A. and Zhang, J. (2015) Cytoplasmic dynein and early endosome transport (review). Cellular and molecular life sciences 72, 3267-3280. PMCID: PMC4534323
  • Xiang, X. (2012) Nuclear positioning: dynein needed for microtubule shrinkage-coupled movement. Curr. Biol. 22 (12), R496-R499.
  • Xiang, X. and Oakley, B. R. (2010). The Cytoskeleton in Filamentous Fungi (book chapter). In: Cellular and Molecular Biology of Filamentous Fungi (Edited by K. Borkovich and D. Ebbole), ASM Press. p209-223.
  • Xiang, X. (2006) A +TIP for a smooth trip. (minireview) J. Cell Biol. 172, 651-654.
  • Current grant support: RO1, NIH/NIGMS "Regulation of cytoplasmic dynein in vivo" (2017-2021).
  • USUHS Awards (2017): Henry Wu award for excellence in the basic sciences; Medical School Dean's Impact award recognizing excellence in research.
  • 2019 Fellow of the American Society for Cell Biology

Bibliography

  • Qiu, R., J. Zhang, and X. Xiang. (2020) The splicing-factor Prp40 affects dynein-dynactin function in Aspergillus nidulans. Mol. Biol. Cell, 31:1289-1301.
  • Qiu, R., Zhang, J., Xiang, X. (2019) LIS1 regulates cargo-adapter-mediated activation of dynein by overcoming its auto-inhibition in vivo. J. Cell Biol. 218, 3630-3646.
  • Qiu, R., J. Zhang, and X. Xiang. (2018) p25 of the dynactin complex plays a dual role in cargo binding and dynactin regulation. J Biol Chem. 293:15606-15619.
  • Zhang, J., R. Qiu, and X. Xiang. (2018) The actin capping protein in Aspergillus nidulans enhances dynein function without significantly affecting Arp1 filament assembly. Scientific reports. 8:11419.
  • Yao, X., Arst, H, Wang, X. and Xiang, X. (2015) Discovery of a vezatin-like protein for dynein-mediated early endosome transport. Mol. Biol. Cell. 26, 3816-3827 (highlighted by MBoC). PMCID: PMC4626066
  • Yao, X., Wang, X. and Xiang, X. (2014) FHIP and FTS proteins are critical for dynein-mediated transport of early endosomes in Aspergillus. Mol. Biol. Cell. 25, 2181-2189 (highlighted by MBoC). PMCID: PMC4091831
  • Zhang, J., Qiu, R., Arst, H.N. Jr, Peñalva, M.A. and Xiang, X. (2014) HookA is a novel dynein-early endosome linker critical for cargo movement in vivo. J. Cell Biol., 218:3630-3646. 204, 1009-1026 PMCID: PMC3998793. (highlighted by JCB In Focus and by Nat. Rev. Mol. Cell Biol in Res. Highlights).
  • Zhang, J., Yao, X., Fischer, L. Abenza J. F., Peñalva. M. A., Xiang, X. (2011) The p25 subunit of the dynactin complex is required for dynein-early endosome interaction. J. Cell Biol. 193, 1245-1255. PMCID:PMC3216330
  • Zhang, J., Li, S., Fischer, R. and Xiang, X. (2003) Accumulation of cytoplasmic dynein and dynactin at microtubule plus ends in Aspergillus nidulans is kinesin dependent. Mol. Biol. Cell 14, 1479-1488.
  • Han, G., Liu, B., Zhang, J., Zuo W., Morris, N. R. and Xiang, X. (2001) The Aspergillus cytoplasmic dynein heavy chain and NUDF localize at the microtubule ends and affect microtubule dynamics. Curr. Biol. 11, 719-724.