Yang Du, PhD

Yang Du, PhD

Name: Yang Du, PhD

USU Department of Primary Appointment: 
Pediatrics
Faculty Rank: 
Assistant Professor
Location: 
Uniformed Services University of the Health Sciences, Bethesda, MD

Research Interests:
Molecular mechanisms of leukemia development
Stem cell self-renewal

Office Phone: 
(301) 295-9714

Education

2000 Ph.D., Texas Tech University Health Sciences Center (TTUHSC), Department of Cell Biology and Biochemistry, Lubbock, TX

Biography

Dr. Du is a molecular biologist and mouse geneticist who is interested in mechanisms responsible for the development of leukemia. He received his Ph.D. in Medical Biochemistry from Texas Tech University Health Sciences Center, where he studied transcription regulation of hematopoietic development in Dr. Simon Williams laboratory. He later joined the laboratory of Drs. Neal Copeland and Nancy Jenkins in the Mouse Cancer Genetics Program at National Cancer Institute-Frederick as a postdoctoral fellow to study leukemia development using mouse models.

Representative publications, projects, and/or deployments

  • 2005 Fellows Award for Research Excellence (FARE), National Institutes of Health
  • 1998 Faculty Award, Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center

Bibliography

  • Nguyen N., Oakley K., Vishwakarma B. A., Han Y., Przychodzen B., Maciejewski J. P., and Du Y. (2016). Myb expression is critical for myeloid leukemia development induced by Setbp1 activation. Oncotarget, 10.18632/oncotarget. 13383.
  • Vishwakarma, B. A., Nguyen, N., Makishima, H., Hosono, N., Gudmundsson, K. O., Negi, V., Oakley, K., Han, Y., Przychodzen, B., Maciejewski, J. P., and Du, Y. (2016). Runx1 repression by histone deacetylation is critical for Setbp1-induced mouse myeloid leukemia development. Leukemia, 30(1), 200-208.
  • Zhou S., Fatima S., Ma Z., Wang Y. D., Lu T., Janke L. J., Du Y., and Sorrentino B. P. (2016). Evaluating the safety of retroviral vectors based on insertional oncogene activation and blocked differentiation in cultured thymocytes. Molecular Therapy, 24(6), 1090-9.
  • Polprasert, C., Schulze, I., Sekeres, M. A., Makishima, H., Przychodzen, B., Hosono, N., Singh, J., Padgett, R. A., Gu, X., Phillips, J. G., Clemente, M., Parker, Y., Lindner, D., Dienes, B., Jankowsky, E., Saunthararajah, Y., Du, Y., Oakley, K., Nguyen, N., Mukherjee, S., Pabst, C., Godley, L. A., Churpek, J. E., Pollyea, D. A., Krug, U., Berdel, W. E., Klein, H. U., Dugas, M., Shiraishi, Y., Chiba, K., Tanaka, H., Miyano, S., Yoshida, K., Ogawa, S., Müller-Tidow, C., and Maciejewski, J. P. (2015). Inhe
  • Huang, D., Nagata, Y., Grossmann, V., Radivoyevitch, T., Okuno, Y., Nagae, G., Hosono, N., Schnittger, S., Sanada, M., Przychodzen, B., Kon, A., Polprasert, C., Shen, W., Clemente, M. J., Phillips, J. G., Alpermann, T., Yoshida, K., Nadarajah, N., Sekeres, M. A., Oakley, K., Nguyen, N., Shiraishi, Y., Shiozawa, Y., Chiba, K., Tanaka, H., Koeffler, H. P., Klein, H. U., Dugas, M., Aburatani, H., Miyano, S., Haferlach, C., Kern, W., Haferlach, T., Du, Y., Ogawa, S., and Makishima, H. (2015). BRCC3 mutations
  • Makishima, H., Yoshida, K., Nguyen, N., Przychodzen, B., Sanada, M., Okuno, Y., Ng, K. P., Gudmundsson, K. O., Vishwakarma, B. A., Jerez, A., Gomez-Segui, I., Takahashi, M., Shiraishi, Y., Nagata, Y., Guinta, K., Mori, H., Sekeres, M. A., Chiba, K., Tanaka, H., Muramatsu, H., Sakaguchi, H., Paquette, R. L., McDevitt, M. A., Kojima, S., Saunthararajah, Y., Miyano, S., Shih, L. Y., Du, Y.*, Ogawa, S.*, and Maciejewski, J. P.* (*co-corresponding authors) (2013). Somatic SETBP1 mutations in myeloid malignan
  • Oakley, K., Han, Y., Vishwakarma, B. A., Chu, S., Bhatia, R., Gudmundsson, K., Keller, J., Chen, X., Vasko, V., Jenkins, N. A., Copeland, N. G., and Du, Y. (2012). Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10. Blood, 119(25), 6099-6108.
  • Aue, G*, Du, Y.*, Cleveland, S. M., Smith, S. B., Davé, U. P., Liu, D., Metais, J. Y., Jenkins, N. A., Copeland, N. G., and Dunbar, C. E. (* Co-first author) (2011). Sox4 cooperates with Pu.1 haploinsufficiency in murine myeloid leukemia. Blood, 118(17), 4674-4681.
  • Du, Y., Jenkins, N. A., and Copeland, N. G. (2005). Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells. Blood, 106(12), 3932-3939.
  • Du, Y., Spence, S. E., Jenkins, N. A., and Copeland, N. G. (2005). Cooperating cancer gene identification via oncogenic retrovirus-induced insertional mutagenesis. Blood, 106(7), 2498-2505.