Ashley Binam

MD, Ph.D

Department of Primary Appointment:
School of Medicine
Preventive Medicine and Biostatistics
Location: Uniformed Services University of the Health Sciences, Bethesda, MD
Research Interests:
Short- and long-term effects of traumatic brain injury (TBI) and TBI-related neuropsychiatric diseases, especially among active duty military personnel and war veterans.
Expanding the DoD Brain Repository
Office Phone


MD and Ph.D: School of Medicine and Surgery of the Catholic University of the Sacred Heart, Rome, Italy


Dr. Iacono received his medical degree (MD) and PhD (in Neuroscience) from the School of Medicine and Surgery of the Catholic University of the Sacred Heart - “Gemelli” Hospital in Rome, Italy. He then completed his residency in Neurology in Italy, which included clinical training periods at the Pitié-Salpêtrière University Hospital in Paris, France and at the National Hospital for Neurology and Neurosurgery, Queen Square, in London, UK. Apart from general neurology and neurological emergencies daily activities, Dr. Iacono focused on neurodegenerative diseases, especially dementias and movement disorders, during his entire clinical and research career. He also participated in numerous early-phase drug international clinical trials. After his clinical and research training in Europe, he received further post-residency training in clinical and experimental neuropathology at Johns Hopkins University, Baltimore, MD. At Johns Hopkins University he started to study and publish novel data related to normal and pathologic aging analyzing clinical, imaging, genetic, and neuropathologic findings from subjects enrolled in historical longitudinal studies of aging such as the Baltimore Longitudinal Study of Aging (BLSA) and the Nun Study. After 4 years at Johns Hopkins, he directed the Brain Bank of the Karolinska Institutet in Stockholm, Sweden. At Karolinska, Dr. Iacono expanded his research on neurodegenerative diseases and co-occurring brain pathologies examining and comparing brains from identical and fraternal twin pairs, all belonging to the Swedish Twin Study of Aging. Dr. Iacono moved back to the US to establish his own brain bank and direct the Neuropathology Research activities for the Biomedical Research Institute of New Jersey and Atlantic Health System, NJ. At the same time, he was appointed associate professor in the Department of Neurology at the Icahn School of Medicine, Mount Sinai Hospital, NY City, NY.
Dr. Iacono joined the Center for Neuroscience and Regenerative Medicine (CNRM) as research associate professor and Deputy Director of the Brain Tissue Repository and Neuropathology Core at the Uniformed Services University of the Health Sciences (USUHS) in Bethesda, MD in the summer of 2016. In 2017, he obtained a faculty appointment as associate professor in the Departments of Neurology and Pathology at USUHS.
As deputy director of the CNRM’s BTR and Neuropathology Core, in collaboration with Dr. Daniel Perl, director of the Core, Dr. Iacono is contributing to establish and expand the first brain bank and neuropathology research center in the world fully dedicated to investigate short- and long-term effects of traumatic brain injury (TBI) and TBI-related neuropsychiatric diseases, especially among active duty military personnel and war veterans. Dr. Iacono is currently expanding his clinical and experimental research investigations participating, collaborating and initiating multiple collaborative grant-funded studies, including imaging-genetic-pathologic correlations analyses of subjects with a history of single-TBI, repetitive-TBI, blast-TBI and TBI-related neurodegenerative diseases, with a special emphasis on different neuropsychiatric aspects. Dr. Iacono has recently established his own lab for basic research studies using human specimens and different rodent and non-rodent animal models as well.

Uniformed Services University of the Health Sciences
Departments of Neurology and Pathology
4301 Jones Bridge Rd.
Bethesda, MD 20814

Representative publications, projects, and/or deployments

1. Szpisjak DF, Edgell DS, Bissonnette B. Potassium as a surrogate marker of debris in cell- salvaged blood. Anesth Analg 2000;91:40-3.

2. Szpisjak DF. Debris elimination from partially-filled cell salvage bowls. Anesth Analg 2001;92:1137-8.

3. Szpisjak DF, Potter PS, Capehart BP. Economic Analysis of an Intraoperative Cell-Salvage Service. Anesth Analg 2004:98:201-5.

4. Serianni RP, Shields CH, Szpisjak DF, Mongan PD. Intraoperative management: peripheral vascular surgery. Anesthesiol Clin North America 2004;22:307-18.

5. Szpisjak DF, Lamb CL, Klions KD. Oxygen Consumption with Mechanical Ventilation in a Field Anesthesia Machine. Anesth Analg 2005;100:1713-17.

6. Szpisjak DF, Javernick EN, Kyle RR, Austin PN. Drive gas volume of a pneumatically powered and controlled field anesthesia machine ventilator. Anesth Analg 2008;107: 1907-1911.

7. Keneally R, Szpisjak DF, et al. Thoracic trauma in Iraq and Afghanistan. J Trauma Acute Care Surg. 2013 May;74(5):1292-7.

8. Szpisjak DF, Starrett-Keller CM. Field anesthesia machine ventilator oxygen consumption in models of high and low pulmonary compliance. Mil Med 2014;179:1465-8.

9. Hudson AJ, Whittaker DR, Szpisjak DF, et al. Tumescent technique without epinephrine for endovenous laser therapy and serum lidocaine concentration. J Vasc Surg: Venous and Lym Dis 2015;3:48-53.

10. Szpisjak DF, Giberman AA. Air compressor battery duration with mechanical ventilation in a field anesthesia machine. Mil Med 2015;180:499-502.


11. Hudson AJ, Whittaker DR, Szpisjak DF, et al. Reply. J Vasc Surg: Venous and Lym Dis 2015;3:345.

12. Szpisjak DF, Horn G, Shalov S, Abes AA, Van Decar L. Minute ventilation limitations of two field transport ventilators. Mil Med 2017;182:e1653-e1657.

13. Keneally RJ, Szpisjak DF, Hoffman P, Park E, Albergo M. Vital signs and physiologic derangement in patients with thoracic trauma in Iraq and Afghanistan. Mil Med 2017;182:e1881-e1884.

14. Hudson AJ, Walter RJ, Flynn J, Szpisjak DF, et al. Ambulatory Surgery has minimal impact on sleep parameters: a prospective observational trial. J Clin Sleep Med; In Press.