SC2I Publications

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SC2i is dedicated to making concrete contributions to critical care medicine. One important method of doing so is by sharing our research through quality peer-reviewed journals.



Jonathan A. Forsberg, Benjamin K. Potter, Matthew B. Wagner, Andrew Vickers, Christopher J. Dente, Allan D. Kirk, Eric A. Elster. Lessons of War: Turning Data Into Decisions EBioMedicine. 2015 Jul 17.



Forsberg JA, Potter BK, Potter EM, Safford SD, Elster EA. Do Inflammatory Markers Portend Heterotopic Ossification and Wound Failure in Combat Wounds? Clin Orthop Relat Res. 2014 May 31.
Be NA, Allen JE, Brown TS, Gardner SN, McLoughlin KS, Forsberg JA, Kirkup BC, Chromy BA, Luciw PA, Elster EA, Jaing CJ. Microbial profiling of combat wound infection through detection microarray and next-generation sequencing J Clin Microbiol. 2014 May 14.
Bell JC, Wolf EJ, Schnall BL, Tis JE, Potter BK. Transfemoral Amputations: Is There an Effect of Residual Limb Length and Orientation on Energy Expenditure? Clin Orthop Relat Res. 2014 Apr 22.
Polfer EM, Hoyt BW, Senchak LT, Murphey MD, Forsberg JA, Potter BK. Fluid Collections in Amputations Are Not Indicative or Predictive of Infection Clin Orthop Relat Res. 2014 Apr 2.
Chromy BA, Eldridge A, Forsberg JA, Brown TS, Kirkup BC, Elster E, Luciw P. Proteomic sample preparation for blast wound characterization Proteome Sci. 2014 Feb. 12(1): p. 10.
Evans KN, Potter BK, Brown TS, Davis TA, Elster EA, Forsberg JA. Osteogenic gene expression correlates with development of heterotopic ossification in war wounds Clin Orthop Relat Res. 2014 Feb.472(2): p. 396-404.
Pubmed id24136804



Crane NJ, Polfer E, Elster EA, Potter BK, Forsberg JA. Raman spectroscopic analysis of combat-related heterotopic ossification development Bone. 2013 Dec. 57(2): p. 335-42.
McBeth P, Crawford I, Tiruta C, Xiao Z, Ahu GQ, Shuster M, Sewell L, Panebianco N, Lautner D, Nicolaou S, Ball CG, Blaivas M, Dente CJ, Wyrzkowski AD, Kirkpatrick AW. Help is in your pocket: the potential accuracy of smartphone-and laptop based remotely guided resuscitative telesonography. Telemed J E Health. 2013 Dec. 19(12): p. 924-30.
Chromy BA, Eldridge A, Forsberg J, Brown TS, Kirkup BC, Jaing C, Be NA, Elster E, Luciw PA. Wound outcome in combat injuries is associated with a unique set of protein biomarkers. J Transl Med. 2013 Nov. 11(1): p. 281.
Pubmed id 24192341
Bevevino AJ, Dickens JF, Potter BK, Dworak T, Gordon W, Forsberg JA. A Model to Predict Limb Salvage in Severe Combat-related Open Calcaneus Fractures Clin Orthop Relat Res. 2013 Nov 19.
Ball CG, Dente CJ, Kirkpatrick AW, Wyrzkowski AD, Williams BH, Nicholas JM, Shaz B, Laupland KB, Vercruysse GA, Salomone JP, Dixon E, Rozycki GS, Feliciano DV. The impact of a mature massive transfusion protocol (1:1:1) on major hepatic injuries: does it increase abdominal closure rates? Can J Surg. 2013 Oct. 56(5): p. 128-34.
Mina M, Winkler A, Dente CJ. Let technology do the work: improving prediction of massive transfusion with the aid of a smartphone app. J Trauma Acute Care Surg. 2013 Oct. 75(4): p. 669-75.
Zink JU, Morse BU, Vercruysse GA, Dente CJ, Jones YR. Remote group A beta-hemolytic streptococcal fascitis and myositis: a rare complication from hematogenous spread of streptococcal pharyngitis Am Surg. 2013 Sep. 79(9): p. 296-7.
Elster EA, Butler FK, Rasmussen TE. Implications of combat casualty care for mass casualty events JAMA.2013 Aug. 310(5): p. 475-6.
Lisboa FA, Forsberg JA, Brown TS, Gage FA, Potter BK, Elster EA. Bilateral lower-extremity amputation wounds are associated with distinct local and systemic cytokine response Surgery. 2013 Aug. 154(2): p.282.
Anam K, Lazdun Y, Davis PM, Banas RA, Elster EA, Davis TA. Amnion-derived multipotent progenitor cells support allograft tolerance induction Am J Transplant. 2013 Jun. 13(6): p. 1416-28.



Evans KN, Forsberg JA, Potter BK, Hawksworth JS, Brown TS, Andersen R, Dunne JR, Tadaki D, Elster EA. Inflammatory cytokine and chemokine expression is associated with heterotopic ossification in high-energy penetrating war injuries J Orthop Trauma. 2012 Nov. 26(11): p. 204-13.
Goldberg SR, , Anand RJ, Como JJ, Dechert T, Dente C, Luchette FA, Ivatury RR, Duane TM. Prophylactic antibiotic use in penetrating abdominal trauma: an eastern association for the surgery of trauma practice management guideline. J Trauma Acute Care Surg. 2012 Nov. 73(5 Supp 4): p. 321-5.
Benfield RJ, Mamczak CN, Vo KC, Smith T, Osborne L, Sheppard FR, Elster EA. Initial predictors associated with outcome in injured multiple traumatic limb amputations: a Kandahar-based combat hospital experience J Orthop Trauma. 2012 Oct. 43(10): p. 1753-8.
Hawksworth JS, Graybill C, Gillern SM, Brown TS, Wallace SM, Davis TA, Elster EA, Tadaki DK.Lymphocyte depletion in experimental hemorrhagic shock in swine. J Inflamm (Lond). 2012 Sep. 9(1): p.34.
Pubmed id 23009382
Watkins CJ, Feingold PL, Hashimoto B, Johnson LS, Dente CJ. Nocturnal violence: implications for resident trauma operative experiences. Am Surg. 2012 Jun. 78(6): p. 657-62.
Morse BC, Dente CJ, Hodgman El, Shaz BH, Winkler A, Nicholas JM, Wyrzkowski AD, Rozycki GS, Feliciano DV. Outcomes after massive transfusion in non-trauma patients in the era of damage control resuscitation. Am Surg. 2012 Jun. 78(6): p. 679-84.
Michetti CP, Fakhry SM, Ferguson PL, Dente CJ, Skeete D. Ventilator associated pneumonia rates at major trauma centers compared with a national benchmark: a multi-institutional study of the AAST. J Trauma Acute Care Surg. 2012 May. 72(5): p. 1165-73.
Hawksworth JS, Graybill JC, Brown TS, Wallace SM, Davis TA, Tadaki DK, Elster EA. Lymphocyte modulation with FTY720 improves hemorrhagic shock survival in swine. PLos One. 2012 Apr. 7(4):
Hodgman El, Morse BC, Dente CJ, Mina MJ, Shaz BH, Nicholas JM, Wyrzykowski AD, Salomone JP, Rozycki GS, Felician DV. Base deficit as a marker of survival after traumatic injury: consistent across changing patient populations and resuscitation paradigms . J Trauma Acute Care. 2012 Apr. 72(4): p.844-51.
Crane NJ, Elster EA. Vibrational spectroscopy: a tool being developed for the noninvasive monitoring of wound healing. J Biomed Opt. 2012 Jan. 17(1):
Pubmed id 22352634
Brown TS, Elster EA, Stevens K, Graybill JC, Gillern S, Phinney S, Salifu MO, Jindal RM. Bayesian modeling of pretransplant variables accurately predicts kidney graft survival Am J Nephrol. 2012. 36(6): p. 561-9.
Alfieri KA, Elster EA, Dunne J. Resuscitation and blood utilization guidelines for the multiply injured, multiple amputee J Surg Orthop. 2012. 21(1): p. 15-21.
Mamczak CN, Elster EA. Complex dismounted IED blast injuries: the initial management of bilateral lower extremity amputations with and without pelvic and perineal involvement J Surg Orthop. 2012. 21(1): p. 14-Aug.



Gillern SM, Sheppard FR, Evans KN, Graybill JC, Gage FA, Forsberg JA, Dunne JR, Tadaki DK, Elster EA.Incidence of pulmonary embolus in combat casualties with extremity amputations and fractures J Trauma. 2011 Sep. 71(3): p. 607-12.
Morse BC, Dente CJ, Hodgman EH, Shaz BH, Nicholas JM, Wyrzykowski AD, Salomone JP, Vercruysse GA, Rozycki GS, Feliciano DV. The effects of protocolized use of recombinant factor vlla within a massive transfusion protocol in a civilian level 1 trauma center. Am Surg. 2011 Aug. 77(8): p. 1043-9.
Davis TA, O'Brien FP, Anam K, Grijalva S, Potter BK, Elster EA. Heterotopic ossification in complex orthopaedic combat wounds: quantification and characterization of osteogenic precursor cell activity in traumatized muscle J Bone Joint Surg Am. 2011 Jun. 93(12): p. 1122-31.
Cannon JW, Zonies DH, Benfield RJ, Elster EA, Wanek SM. Advanced en-route critical care during combat operations Bull Am Coll Surg. 2011 May. 96(5): p. 21-9.
Ball CG, Salomone JP, Shaz BH, Dente CJ, Tallah C, Anderson K, Rozyci GS, Feliciano DV.Uncrossmatched Blood transfusion for trauma patients in the emergency department: incidence, outcomes and recommendations. Can J Surg. 2011 Apr. 54(2): p. 115-5.
Dente CJ, Feliciano DV. Torso vascular trauma in an urban level-1 trauma center. Perspect Vasc Surg Endovasc Ther. 2011 Mar. 23(1): p. 36-46.
Stojadinovic A, Kyle Potter B, Eberhardt J, Shawen SB, Andersen RC, Forsberg JA, Shwery C, Elster EA, Schaden W. Development of a prognostic naive bayesian classifier for successful treatment of nonunions. J Bone Joint Surg Am. 2011 Jan. 93(2): p. 187-94.
Hahm G, Glaser JJ, Elster EA. Biomarkers to predict wound healing: the future of complex war wound management. Plast Reconstr Surg. 2011 Jan. 127(Suppl): p. 21S-26S.
Pubmed id 21200268
Brown TS, Hawksworth JS, Sheppard FR, Tadaki DK, Elster EA. The inflammatory response in combat wounds is associated with critical colonization. Surg Infection. 2011.
Gillern SM, Evans KN, Graybill JC, Forsberg JA, Dunne JR, Tadaki D, Stojadinovic A, Elster EA. Incidence of pulmonary embolus in patients with high energy wartime extremity wounds. J Trauma. 2011.
Hwang P, Porterfield N, Pannell D, Davis T, Elster E. Trauma is Danger. Journal of Translational Medicine.2011. 9(92):
N. Crane, F. O'Brien, J. Forsberg, B. Potter, E. Elster. Developing a toolbox for analysis of warrior wound biopsies: vibrational spectroscopy. Proc SPIE. 2011.



Ball CG, Navsaria P, Kirkpatrick AW, Vercler C, Dixon E, Zink J. Laupland KB, Lowe M, Salomone JP, Dente CJ, Wyrykowski AD, Hameed SM, Widder S, Inaba K, Ball JE, Rozycki GS, Montgomery SP, Hayward T, Feliciano DV. The Impact of country and culture of end-of-life care for injured patients: results of an international survey J Trauma . 2010 Dec. 69(6): p. 1323-34.
Potter BK, Forsberg JA, Davis TA, Evans KN, Hawksworth JS, Tadaki D, Brown TS, Crane NJ, Burns TC, O'Brien FP, Elster EA. Heterotopic ossification following combat-related trauma. J Bone Joint Surg Am.2010 Dec. 92(Suppl 2): p. 74-89.
FR Sheppard, P Keiser, DW Craft, F Gage, M Robson, TS Brown, K Petersen, S Sincock, M Kasper, J Hawksworth, D Tadaki, TA Davis, A Stojadinovic, E Elster. The majority of U.S. combat casualty soft tissue wounds are not infected or colonized upon arrival or during treatment at a continental United States military medical facility. Am J Surg. 2010 Oct. 200(4): p. 489-95.
Pubmed id 20887842
Hurst FP, Jindal RM, Graham LJ, Falta EM, Elster EA, Stackhouse GB, Agodoa LY, Lentine KL, Salifu MO, Abbott KC. Incidence, predictors, costs, and outcome of renal cell carcinoma after kidney transplantation: USRDS experience Transplantation. 2010 Oct. 90(8): p. 898-904.
Elster EA, Hawksworth J, Chang O, Leeser DB, Ring M, Tadaki DK, Kleiner DE, Brown TS, Mannon RB.Probabilistic (Bayesian) modeling of gene expression in transplant glomerulopathy. J Mol Diagn. 2010 Sep. 12(5): p. 653-63.
Pubmed id 20688906
Ball CG, Dente CJ, Kirkpatrick AW, Shah AD, Rajani RR, Wyrzkowski AD, Vercruysse GA, Rozycki GS, Nicholas JM, Salomone JP, Feliciano DV. Occult pneumothoraces in victims of penetrating trauma: does mechanism matter? Can J Surg. 2010 Aug. 53(4): p. 251-5.
NJ Crane, TS Brown, KN Evans, JS Hawksworth, S Hussey, DK Tadaki, EA Elster. Monitoring the healing of combat wounds using raman spectroscopic mapping. Wound Repair Regen. 2010 Jun.
Pubmed id 20546554
Brown TS, Safford S, Caramanica J, Elster EA. Biomarker use in tailored combat casualty care. Biomark Med. 2010 Jun. 4(3): p. 465-73.
Pubmed id 20550480
Ball CG, Wyryzkowski AD, Kirkpatrick A, Dente CJ, Nicholas JM, Salomone JP, Rozycki GS, Kortbeek JB, Feliciano DV. Thoracic needle decompression for tension pneumothoraces: clinical correlation with catheter length. Can J Surg. 2010 Jun. 53(3): p. 184-8.
Sullivan PS, Dente CJ, Patel S, Carmichael M, Srinivasan JG, Wyrzkowski AD, Nicholas JM, Salomone JP, Ingram WL, Vercruysse GA, Rozcyki GS, Feliciano DV. Outcome of ligation of the inferior vena cava in the modern era. Am J Surg. 2010 Apr. 199(4): p. 500-6.
Dente CJ, Shaz BH, Nicholas JM, Harris RS, Wyrzykowski AD, Ficke BW, Vercruysse GA, Feliciano DV, Rozycki GS, Salomone JP, Ingram WL. Early predictors of Massive Transfusion in Patients Sustaining Torso Gunshot Wounds in A Civilian Level I Trauma Center J Trauma . 2010 Feb. 68(2): p. 298-304.
Shaz BH, Dente CJ, Nicholas JM, Macleod JBA, Young AN, Easley K, Ling Q, Harris RS, Hillyer CD.Increased number of coagulation products in relationship to red blood cell products transfused improves mortality in trauma patients. Transfusion. 2010 Feb. 50(2): p. 493-500.
Stojadinovic AS, Eberhardt J, Brown TS, Hawksworth JS, Gage F, Tadaki DK, Forsberg JA, Davis TA, Potter BK, Dunne JR, Elster EA. Development of a bayesian model to estimate health care outcomes in severely wounded. Journal of Multidisciplinary Healthcare. 2010. 2010(3): p. 125-35 .



Hawksworth JS, Stojadinovic A, Gage FA, Tadaki DK, Perdue PW, Forsberg J, Davis TA, Dunne JR, Denobile JW, Brown TS, Elster EA. Inflammatory biomarkers in combat wound healing Ann Surg. 2009 Dec. 250(6): p. 1002-7.
Utz ER, Elster EA, Tadaki D, Gage F, Perdue PW, Stojadinovic A, Hawksworth J, Brown TS. Matrix metalloprotease (MMP) expression is associated with wound failure in traumatic war injuries. J Surg Res.2009 Sep.
Pubmed id 20056248
Dunne JR, Hawksworth JS, Stojadinovic A, Gage F, Tadaki DK, Perdue PW, Forsberg J, Elster EA.Perioperative blood transfusions in combat casualties: a pilot study. J Trauma. 2009 Apr. 66(4): p. 150-6.
Pubmed id 19359959
Forsberg JA, Pepek JM, Wagner S, Wilson K, Flint J, Andersen RC, Tadaki D, Gage FA, Stojadinovic A, Elster EA. Heterotopic ossification in high-energy wartime extremity injuries, prevalence and risk factorsJ Bone Joint Surg Am. 2009. 91(5): p. 1084-91.



Forsberg JA, Elster EA, Andersen RC, Nylen E, Brown TS, Rose MW, Stojadinovic A, Becker KL, McGuigan FX. Correlation of procalcitonin and cytokine expression with dehiscence of wartime extremity wounds. J Bone Joint Surg Am. 2008 Mar. 90(3): p. 580-8.
Pubmed id 18310708



Kirk AD, Hale DA, Ford E, Kleiner DE, Kampen RL, Elster EA, Swanson SJ, Cendales L, Cropper T, Hale L, Jordan S, Koussis T, Peretti J, Sloane A, Salaita C, Ring M, Chamberlain C, Mannon RB. Solid Organ Transplantation at the National Institutes of Health: Development of a Research Based Transplantation Practice In: Cecka and Terasaki, editors. Clinical Transplants 2005. Los: UCLA Tissue Typing Laboratory;2006. 131-144.