Elke Bergmann-Leitner Ph.D., MSc

Education

Postdoctoral fellow 1992-1996: National Cancer Institute/ NIH Bethesda, MD
Ph.D. 1992 -summa cum laude- (Distribution of T-cells, B-cells and ED-1 positive macrophages in spleen and autotransplanted splenic tissue after intravenous immunization: a comparison of the effect of soluble and cellular antigen from Escherichia coli). Institute of Chemistry and Biochemistry at the University of Salzburg

M.S. 1990: (Regeneration of autotransplanted splenic tissue in the course of time),Institute for Biology, Biochemistry and Biophysics, Department of Biochemistry
University of Salzburg/Austria

Biography

Dr. Elke Bergmann-Leitner currently works at the Center for Infectious Disease Research, Walter Reed Army Institute of Research. She is heading the Immunology Core; the mission is to evaluate immune responses induced by vaccines in an effort to identify immune correlates of protection against infectious diseases. Besides immunoprofiling, the labs are continuously developing and optimizing readout assays for immunological and parasitological applications.

Career Highlights: Positions, Projects, Deployements, Awards and Additional Publications

Nov 2017: Research Prof. Dept Medicine USUHS

October 2014- present: Science and Technology Manager Level III (Army AT&L Workforce)

August 2013- present: Chief Flow Cytometry Center, US Military Malaria Research Program

February 2001- Jan 2014: Research Scientist, WRAIR (Characterization of anti-malaria immune responses induced by DNA vaccines; functional characterization of growth- and invasion-inhibitory antibodies against blood stages of P.falciparum; development of high-throughput functional assays for vaccine evaluation, characterization of novel malarial antigens as vaccine candidates); Contractor Clinical Research Management

July 1998-January 2001: Research Fellow, LTIB/NCI/NIH (Development of model systems for the study of tumor escape mechanisms)

Apr.1996-July 1998: Visiting Associate, LTIB/NCI/NIH (Human T-cell responses to point mutated ras oncogenes in healthy individuals and cancer patients)

Editorial board member:Clinical Immunology Infection and Immunity

complete publication list: http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/bibliography/48798681/descending

https://www.researchgate.net/publication/275714181_Simulating_the_immune_response

Presentation of novel flow cytometric methods - https://www.youtube.com/watch?v=o1zQXGHfAZI

Representative Bibliography

TREY A. KNEPPER, ELIZABETH H. DUNCAN, TATYANA SAVRANSKY ELKE S. BERGMANN-LEITNER. Novel ELISA method as exploratory tool to assess immunity induced by radiated attenuated sporozoites to decipher protective immunity. Mal J 2017 (16); e 484

CHAUDHURY S, DARKO C, REGULES JA, DUTTA S, WALLQVIST A, JONGERT E, WATERS NC, LEMIALE F, BERGMANN-LEITNER E. Delayed fractional dose regimen of the RTS,S/AS01 malaria vaccine candidate enhances an IgG4 response that inhibits serum opsono-phagocytosis"

FAROOQ F., BECK, K., PAOLINO K.M., PHILLIPS R. WATERS NC, REGULES, JA, BERGMANN-LEITNER E.S. Circulating follicular T helper cells and cytokine profile in humans following vaccination with the rVSV-ZEBOV Ebola vaccine

CHAUDHURY S, OCKENHOUSE CF, REGULES JA, DUTTA S, WALLQVIST A, JONGERT E, WATERS NC, LEMIALE F, BERGMANN-LEITNER E. The biological function of antibodies induced by the RTS,S/AS01 malaria vaccine candidate is determined by their fine specificity.

FAROOQ F, BERGMANN-LEITNER ES. Immune Escape Mechanisms are Plasmodium's Secret Weapons Foiling the Success of Potent and Persistently Efficacious Malaria Vaccines.

BERGMANN-LEITNER, ES, CHAUDHURY S. Simulating the immune response.

BERGMANN-LEITNER ES, LI Q, CARIDHA D, O’NEIL MT, OCKENHOUSE CF, HICKMAN M, ANGOV E. Protective immune mechanisms against pre-erythrocytic forms of Plasmodium berghei depend on the target antigen.

BERGMANN-LEITNER ES, CHAUDHURY S, STEERS NJ, SABATO M, DELVECCHIO V, WALLQVIST AS, OCKENHOUSE CF, ANGOV E. Computational and experimental validation of B and T-cell epitopes of the in vivo immune response to a novel malarial antigen.

BERGMANN-LEITNER E., HOSIE H, TRICHILO J, DERISO E, RANALLO R, ALEFANTIS, SAVRANSKAYA T, GREWAL P, OCKENHOUSE O, VENKATESAN M, DELVECCHIO V, ANGOV E. Self-adjuvanting bacterial vectors expressing pre-erythrocytic antigens induce sterile protection against malaria.

BERGMANN-LEITNER E. S., DUNCAN E.H., MEASE R.M., ANGOV E Impact of pre-existing MSP1-42 allele-specific immunity on potency of an erythrocytid Plasmodium falciparum vaccine.