Marzena E Pazgier


Department of Primary Appointment:
School of Medicine
Professor of Medicine
Location: Uniformed Services University of the Health Sciences, Bethesda, MD
Research Interests:
structural biology, protein engineering, structure based design
infectious disease, HIV, antimicrobial agents
Office Phone


1996 MS Biochemistry and Biotechnology, Lodz University of Technology
2001 PhD, Chemical Engineering, Lodz University of Technology
2007, Postdoctoral Fellow, NIH, National Cancer Institute Macromolecular Crystallography Laboratory, Frederick, MD


Dr. Pazgier graduated from Lodz University of Technology in technical sciences and did her postdoctoral training at the Molecular Crystallography Laboratory in National Cancer Institute-Frederick in structural biology by X-ray crystallography. In 2007 she became a faculty member of the Institute of Human Virology and Department of Biochemistry and Molecular Biology of University of Maryland School of Medicine where she established her independent research program in structural biology of infectious disease. Dr. Pazgier joined the Department of Medicine of USUHS in 2018 in the Infectious Disease Division.
Dr. Pazgier's research focuses on understanding, at the molecular level, of mechanisms involved in innate and adaptive responses to infectious disease with the long term goal to generate knowledge required to develop new vaccines and antibody therapeutics. Her research is highly interdisciplinary, involving structural biology, contemporary biophysical and protein engineering techniques, and structure-function analyses.

Representative publications, projects, and/or deployments

2018 - present Associate Professor, Infectious Diseases Division, Department of Medicine of F. Edward Hebert School of Medicine, Uniformed Services University of Health Sciences, Bethesda, MD

2017-2018 - Associate Professor, Department of Biochemistry and Molecular Biology, Institute of Human Virology, University of Maryland School of Medicine (UMSOM), Baltimore, MD

2009-2017 - Assistant Professor, Department of Biochemistry and Molecular Biology, Institute of Human Virology, UMSOM, Baltimore, MD

2007-2009 - Research Associate, Department of Biochemistry and Molecular Biology, Institute of Human Virology, University of Maryland School of Medicine,, Baltimore, MD

1993-1995 Scholarship for outstanding undergraduate, National Science Foundation and the Ministry of Science of Poland, awarded annually for top 1% of national students

2001 - The Research Council Award for outstanding PhD Thesis, Technical University of Lodz, Poland

2003 - Outstanding Young Scientists Science Award, Polish Academy of Sciences and the Presidents of the Universities of Lodz, Poland

2014 - Early Career Investigator Recognition Award, Global HIV Vaccine Enterprise, Bill and Melinda Gates Foundation

2017 - Special Award for Outstanding Achievements and Productivity in the field of Basic Science and HIV Vaccine, Institute of Human Virology, UMSOM

2011-present, multiple Research Project grants funded by NIH (RO1s and P01s) and Bill and Melinda Gates Foundation (Program grants)


Tolbert WD, Subedi GP, Gohain N, Lewis GK, Patel KR, Barb AW, Pazgier M(2019) From Rhesus macaque to human: structural evolutionary pathways for Immunoglobulin G subclasses; mAb, DOI of your paper is: 10.1080/19420862.2019.1589852

Tolbert WD, Sherburn RT, Van V, Pazgier M (2019) Structural Basis for Epitopes in the gp120 Cluster A Region, the HIV Envelope Targets Involved in Potent Effector Cell Activity, Viruses, Jan 16;11(1)

Xu D, Liao C, Zhang B, Tolbert WD, He W, Dai Z, Zhang W, Yuan W, Pazgier M, Liu J, Yu J, Sansonetti PJ, Bevins CL, Shao Y, Lu W. (2018) Human Enteric α-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion, Immunity.;48(6):1233-1244

Sajadi MM, Dashti A, Tehrani ZR, Tolbert WD, Seaman MS, Ouyang X, Gohain N, Pazgier M, Kim D, Cavet G, Yared J, Redfield RR, Lewis GK, DeVico AL (2018) Identification of near pan-neutralizing antibodies against HIV-1 by deconvolution of plasma antibodies, Cell. 2018 Jun 14;173(7):1783-1795

Lewis G, Pazgier M, DeVico A (2017) Survivor's Remorse: Antibody-Mediated Protection Against HIV-1; Immunological reviews;275(1):271-284.

Tolbert WD, Gohain N, Alsahafi N, Van V, Orlandi Ch, Ding S, Martin L, Finzi A, Lewis GK, Ray K, Pazgier M (2017) Targeting the Late Stage of HIV-1 Entry for Antibody-dependent Cellular Cytotoxicity: Structural Basis for Env Epitopes in the C11 Region, Structure, 25(11):1719-1731

Gohain N, Tolbert WD, Orlandi Ch, Richard J , Ding S, Chen X, Bonsor DA, Sundberg EJ, Lu W, Ray K, Finzi A, Lewis GK, Pazgier M. (2016) Molecular basis for epitope recognition by non-neutralizing anti-gp41 antibody F240, Scientific reports: Nov 9;6:36685.

Tolbert WD, Gohain N, Veillette M, Chapleau J-P, Orlandi Ch, Visciano ML, Ebadi T, DeVico T, Fouts TR, Finzi A, Lewis G, Pazgier M (2016) Paring down HIV-1 Env: Design and Structure of an Independent Inner Domain of gp120 that Stably Expresses the A32 Epitope Sub-region of ADCC Epitope Cluster A, Structure: 24(5):697-709