Aneeta Patel MSc

Education

University of Oxford, London U.K. 1971 High School “O” Level.
Eastham College of Technology, London, U.K.1973 Advanced “A” Levels in high level sciences.
University of Wales, Cardiff, Wales, U.K. 1977. B.Sc Microbiology.
School of Medical Technology, Washington Hospital Center, Washington D.C.1982. Medical technology (ASCP)
University of Maryland, College Park, Maryland. 1984. B.Sc Management Technology.
Loyola College, Baltimore, Maryland. 1987 M.Sc Management Technology.

Biography

Curriculum Vitae
Aneeta Patel, M.Sc.
Endocrine Section, Department of Pediatrics.

Experience:
2000 - Present USUHS Research Assistant Professor, Bethesda MD

2001- Present Director, USUHS Department of Pediatrics Laboratories
Bethesda, MD

1995 – 2000 Molecular Biology Supervisor
The Department of Clinical Investigation (DCI).
Walter Reed Army Medical Center, Washington DC

1993 – 1995 Research Biologist, Renal Cell Biology
NIH, National Institute of Diabetes, Digestive and Kidney Diseases
Bethesda, Maryland

1988 – 1993 Research Biologist, Kidney Diseases Section
National Institute of Diabetes, Digestive and Kidney Diseases
Bethesda, Maryland

1987 – 1988 Research Biologist, Division of Flow Cytometry / Virology
FDA Center for Drugs, Biologics Research and Review

1984 – 1985 Medical Technologist, Team Leader
Department of Pathology and Area Lab Services
Hematology/ Emergency Section
Walter Reed Army Medical Center, Washington DC

1982 – 1984 Medical Technologist, Microbiology Laboratory
Suburban Hospital, Bethesda, Maryland.

1979 – 1982 Medical Technologist
Washington Hospital Center, Washington, D.C.

Teaching Experience:
2000 – Present Uniformed Services University of Health Sciences, Bethesda, MD.
Facilitator for the Ethical, Legal, and Social aspects of Medical care Course. Training
Medical students, Physicians, Fellows and Laboratory Personnel in Molecular Biology and
Immunology protocols.
1995 – 2001 Mentor for Washington Center Undergraduate and Medical Students
(3 months/ Semester)
1995 – 2000 Walter Reed Army Medical Center
Molecular Biology Course Instructor for:ENT, Surgery, Ob / Gyn, Opthamology,
Medicine, Nephrology, Adult and Pediatric Endocrinology and GI.
1998 – 2000 Walter Reed Army Medical Center Clinicians (Staff and GME).
6 Week Short Course. Lecturer and Instructor for Molecular Biology,
RNA and DNA Extractions, PCR, restriction enzyme digests, DNA
sequencing, cloning, HPLC, Immunology Techniques.
1998 University of Cairo, Egypt. Instructor for Major Megeed in Molecular Biology Techniques.
1997 Walter Reed Army Medical Center, Washington D.C.
Department of Surgery, Lecturer Grand Rounds - Introduction to
Molecular Biology.
1996 Walter Reed Armed Institute of Research, Washington D.C.
Lecturer Department of Physiology, Apoptosis: A Review.
1995 Walter Reed Army Medical Center (Amplicor / Roche)
Instructor in Hepatitis C viral load screening in Military Personnel.

Awards/Honors:

1998 - Merck Fellow’s Research Award, The Endocrine Society $ 30,000 New Orleans, LA. : Wingo ST, Patel A, Tuttle RM, Ringel M, Lukes Y, Djuh Y, Anderson J, Dontknow P, Levine M, and Francis G. “Detection of Thyroglobulin (Tg) mRNA in Peripheral Blood From Normal Subjects Using a Simplified Extraction Technique”

2000- Endocrine Fellow’s Foundation Research Grant, Thyroid Research Advisory Council. $7,500” Comparative Genomic Hybridization of Differentiated Thyroid Cancers” A.Patel – participant, A. Bauer-recipient
2001- Howard Johnson Research Award, $500. Uniformed Services Section, American Academy of Pediatrics, Louisville, KY. A Straight, A Patel, C Fenton, C Dinauer, RM Tuttle, and GL Francis “ Thyroid cancers that express telomerase follow a more aggressive clinical course for children and adolescents”.

2001- Merck Fellow’s Research Award, The Endocrine Society , Denver, CO, Bauer A, Gupta S, Shah R, Terrell R, Patel A, Saji M, Ringel M, Tuttle RM, and Francis GL “ Vascular endothelial Growth Factor Monoclonal Antibody (VEGF-MAb) Inhibits Growth of Anaplastic Thyroid Carcinoma Xenografts in Nude Mice”
2002- finalist Ogden Bruton Award, Uniformed Services Section, American Academy of Pediatrics San Diego, CA, Moores R, Patel A, Park D, Ringel M, and Francis GL “ A 60 kilodalton phosphotyrosine containing protein is over-expressed by anaplastic thyroid carcinoma and regulated by vascular endothelial growth factor”

2002- First Prize, Poster Presentation, The International Society for Preventive Oncology Presidents’ Award for Scientific Excellence Penko K, Moores R, Patel A, Tuttle RM, Saji M, Ringel M, Francis GL “Anaplastic and Differentiated Thyroid Carcinoma Express Different Profiles of Angiogenic Stimuli and Inhibitors”
2004- Finalist Ogden Bruton Competition Seattle WA, Uniformed Services Section, American Academy of Pediatrics
Straight A, Bauer A, Oakley K, Patel A, Scouten W, Tuttle RM, Jimeno J, and Francis GL “ Aplidine Reduces in Vitro Growth and the Expression fo Angiogenic Genes by Medullary Thyroid Cancer (MTC)”

2004- Semi-Finalist Howard Johnson Competition, Uniformed Services Section, American Academy of Pediatrics, Seattle, WA Costello A, Rey-Hipolito C, Patel A, Tuttle RM and Francis GL” Childhood Thyroid Cancers that Express CD-40 Ligand have a Greater Risk of Recurrence”

2004- Winner, Val Hemming Competition, Uniformed Services Section, American Academy of Pediatrics, Seattle, WA Walker T, Jensen K, Scouten W,Patel A, Saji M, Ringel M, and Francis GL,“Iodide Inhibits Phosphorylation of protein Kinase B (Akt) and Extracellular Signal Regulated Protein Kinase (ERK) in FRTL-5 Rat” Thyroid Cells.”

2010- Winner, International Thyroid Congress, Paris, France, Young Investigator Award, poster: Jensen K, Costello J, Patel A, Bauer A, Vasko V. “ Anoikis in Thyroid Cancer Cells”.
Committee assignments:
USUHS Radiation Safety Committee 2001- 2004

Professional Societies:

1984 to Present American Society of Clinical Pathology
1986 to Present Foundation of American Society of Experimental Biology
1997 to Present American Society of Clinical Oncology

Published Abstracts:

1. Patel A., Fenton C, Terrell R, Adair C, Pletcher S, Tuttle RM, Francis G.L.
Detection of tyrosine kinase in childhood thyroid cancers. Thyroid, 8:1228, 1998
2. Ramirez R, Fenton C, Patel A., Dinauer C, Tuttle RM, Francis G.L.
Over-expression of cMET is associated with increased recurrence in Childhood Thyroid Cancer. Pediatr Res, 45:96A, 1999.
3. Folstad A, Patel A., Fenton C, Dinauer C, Tuttle RM, Francis G.L.
Expression of Proliferating cell nuclear antigen (Ki-67) is increased in malignant thyroid tumors of children and young adults. Pediatr Res, 47: 128A, 2000.
4. Fenton C, Patel A., Terrell R, Dinauer C, Tuttle RM, Francis G.L.
Nitrotyrosine (N-TYR) but not endothelail nitric oxide synthase (Enos) is increased in differentiated thyroid cancers (DTC) of children and young adults. Pediatr Res,47: 127A, 2000.
5. Gillespie DL, Patel A,Fileta B., Chang A., Barnes S, Flagg A, Villavicencio JL,
Rich NM. Expression of MMP-1(active form) and MM-13 (latent form) varies by location in incompetant greater saphenous veins. J Surgical Research 2000;93:369.
6. Gillespie DL, Patel A, Fileta B, Chang A, Barnes S, FlaggA, Villavincencio JL,Rich NM, Expression of MMP-1 (active form) and MMP-13 (latent form) Varies by Location in Incompetant Greater Saphenous Veins J Surg Research 2000;93:369
7. Gillespie DL, Patel A, Fileta B, Chang A, Barnes S, Flagg A, Villavicencio JL, Rich NM, Expression of MMP-1 (active form) and MMP-13 (latent form) and MMP-13 (latent form) Gene Expression of MMP-1 and MMP-13 Is Upregulated with Worsening Venous Reflux in Patients with Venous Insufficiency J Invest Derm 2001;117(2),520
8. Gillespie DL, Patel A., Fileta B, Chang A, Barnes S, Flagg A, Villavicencio JL,
Rich NM. Expression of MMP-1 (active form) and MMP-13 (latent form) Gene expression of MMP-1 and MMP-13 is upregulated with worsening venous reflux in patients with venous insufficiency. J Invest Dermatology 2001;117(2),520.
9 Gupta S. Patel A, Jhiang S, Fenton C, Dinauer C,Tuttle RM, Francis G.L. Sodium Iodide symporter(NIS) expression may indicate a favorable prognosis for thyroid carcinoma of children and adolescents.
Pediatr Res,49:104A, 2001.
10. Shah R, Patel A., Gupta S, Terrell R, Fenton C, Dinaeur C, Tuttle RM, Francis G.L.
Expression of the Antigen Presentation Co-Activator (B7-1) is Increased in Childhood Thyroid Carcinoma. Pediatr Res 49: 104 A 2001
11. Gupta S, Folstad A, Patel A., Fenton C, Dinauer C, Tuttle RM, Francis G.L.
Infiltration of differentiated thyroid carcinomas by proliferating lymphocytes is Associated with Improved Disease-Free Survival for Children and Adolescents. Pediatr Res, 49: 104A, 2001
12. Bauer AJ, Patel A., Haddad BR, Terrell R, Fenton C, Dinauer C, Tuttle RM,
Francis G.L. The DNA Repair Enzymes (hMSH2 and hMLH1) are Expressed by Childhood Thyroid Carcinoma. Pediatr Res 49: 104 A ,2001
13. Straight A, Patel A., Fenton C, Dinauer C, Tuttle RM and Francis G.L.
Thyroid Cancers Which Express Telomerase have an Increased Recurrence Risk for Children and Adolescents. Pediatr Res, 49: 104A, 2001
14. Penko K, Moores R, Patel A, Tuttle RM, Ringel M, and Francis G.
Multiple angiogenic stimuli are over-expressed by anaplastic thyroid carcinoma. Pediatr Res, 2002.
15. Moores R, Park D, Patel A, Bauer A, Fileta B, Abdelrahim M, Tuttle RM, Ringel M, and Francis G.
In vitro expression of a 60kD phosphoprotein is increased in anaplastic (ATC) compared to less aggressive (NPA) thyroid cancer cells. Pediatr Res, 2002.
16. Bauer A, Penko K, Moores R, Patel A, Tuttle RM, Ringel M, and Francis G. Treatment of thyroid cancer xenografts with vascular endothelial growth factor (VAGF) antibody (VEGF-MAb) changes expression of factors that support angiogenesis. Pediatr Res, 2002.
17. Scouten W, Patel A, DiLauro R, and Francis G.
Cytoplasmic staining for the paired homeobox gene, PAX-8, suggests a poor prognosis for thyroid carcinoma of children and adolescents. Uniformed Services Section, American Academy of Pediatrics, San Diego, CA, March 2002.
18. Bauer A, Patel N, Terrell R, Doniparthi K, Patel A, and Francis G.
Treatment of anaplastic thyroid carcinoma xenografts with vascular endothelial growth factor monoclonal antibody is asscoiated with increased wild-type p53 expression. Uniformed Services Section, American Academy of Pediatrics, San Diego, CA, March 2002.
19. Bauer A, Patel A, Ringel M, and Francis G.
Angiogenesis in thyroid carcinoma is supported predominantly, and perhaps exclusively, by vascular endothelial growth factor. Uniformed Services Section, American Academy of Pediatrics, San Diego, CA, March 2002.
20. Moores R, Patel A, Park D, Ringel M, and Francis G.
A 60 kilodalton phosphotyrosine containing protein is over-expressed by anaplastic thyroid carcinoma and regulated by vascular endothelial growth factor. Uniformed Services Section, American Academy of Pediatrics, San Diego, CA, March 2002.
21. Penko K, Moores R, Patel A, Tuttle RM, Saji M, Ringel M, and Francis G. Anaplastic and differentiated thyroid carcinoma express different profiles of angiogenic stimuli and inhibitors. Predictive Oncology and Intervention Strategies, The Pasteur Institute, Paris, France, February 11, 2002.
22. Penko K, Moores R, Patel A, Tuttle RM, Ringel M, and Francis G. Multiple angiogenic stimuli are over-expressed by anaplastic thyroid carcinoma. Pediatr Res, 51:126A, 2002.
23. Modi J, Patel A, Terrell R, Tuttle RM and Francis G. Childhood thyroid cancers that contain a mixture of lymphocytes have favorable prognostic indicators. Pediatr Res, 53:144A, 2003.
24. Gydee H, O’Neill JT, Patel A, Bauer AJ, Tuttle RM and Francis G. Childhood Thyroid Cacners Express Insulin-like growth factor-1 (IGF-1) and the IGF-1 Receptor (IGF-1R) and Aggressive Cancers are More Likely to Express IGF-1-R. Pediatr Res, 53:144A, 2003.
25. Straight A, Patel A, Bauer A, Saji M, Ringel M, Tuttle RM, and Francis G. Insulin-like Growth Factor-1 (IGF-1), IGF-2 and the IGF Binding Proteins are Differentially Expressed by Anaplastic and Differentiated Thyroid Cancers. Pediatr Res, 53:144A, 2003.
26. Costello A, Rey-Hipolito C, Patel A, Tuttle RM, Francis G. Childhood Thyroid Cancers that Express CD-40 Ligand Have a Greater Risk of Recurrence. Pediatr Res, 55:141A, 2004.
27. Moores R, Adly M, Patel A, Ji X, Jiang G, Datta R, Jozwik C, Jacobowitz DM, Francis G. Unique Patterns of Protein Expression Correlate with the Level of Differentiation in Thyroid Cancers. Pediatr Res, 55:141A, 2004.
28. Straight A, Bauer A, Oakley K, Patel A, Scouten W, Tuttle RM, Jimeno J, Francis G. Aplidine Inhibits Growth and Angiogenic Gene Expression in Medullary Thyroid Cancer (MTC). Pediatr Res, 55:142A, 2004.
29. Penko K, Livezey J, Fenton C, Patel A, Nicholson D, Flores M, Oakley K, Tuttle RM, Francis G.
BRAF Mutations are less Common in Childhood papillary Thyroid Cancer (PTC) than in Adult PTC.
Thyroid,14: 750, 2004.
30. Vasko V, Adly M, Ringel M, Saji M, Patel A, Burman K, Ji X, Jiang G, Datta R, Jozwik C, Jacobowitz D, Moores R, Francis G. Vimentin is Expressed by Papillary thyroid Cancer Cells (NPA) In Vitro Where the Intracellular Localization is Regulated by Insulin and Akt Activation. Thyroid, 14: 699
31. Jensen K, Mackenzie E, Vasko V, Patel A, Oakley K, Saji M, Ringel M, Francis G.
Expression of DNA Methyltransferase varies among Thyroid Tumors and according to the extent of disease for papillary Thyroid Carcinomas. Endocrine Society Annual Meeting, Jun 2005 .
32. Jensen K, Patel A, Bauer A, Saji M, Vasko V. Treatment with DNA methylation inhibitors induce differentiation but may also induce expression of genes involved in Epithelial- Mesenchymal transition. American Thyroid Association Annual Meeting, Oct 2006.
33. Jensen K, Patel A, Bauer A, Vasko V. Targeting of epigenetic regulators in Thyroid cancer. Uniformed Services Pediatric Seminar ( AAP meeting), Mar 2007.
34. Jensen K, Patel A, Kuehn D, Bauer A, Vasko V. E-Cadherin gene promoter methylation in Papillary Thyroid Cancer and in lymph node metastases. Endocrine Society Annual Meeting, Jun 2007.
35. Jensen K, Patel A, Bauer A, Vask V. Thyroid cancer invasion and metastases: The role of Epithelial –Mesenchymal Transition. Bailey K Ashford competition, April 2007
36. Jensen K, Patel A, Bauer A, Vasko V. Epigenetic regulation of Oct-4 expression in thyroid papillary cancer and lymph node metastases. American Thyroid Association Annual meeting, Oct 2007.
37. Jensen K, Patel A, Bauer A, Vasko V. Anti-angiogenesis treatment activates notch signaling in thyoid cancer cells. American Thyroid Association Annual meeting, Oct 2008 .
38. Jensen K, Patel A, Larin A, Savchenco V, Bauer A,Yim K, Vasko V.
Human herpes virus is frequently detected in metastatic thyroid cancer and induces resistance to anoikis in thyroid cancer cell lines. American Thyroid Association Annual meeting, Oct 2008.
39. Jensen K, Patel A, Larin A, Savchenco V,Bauer A, Yim K, Vasko V. Human herpes virus is frequently detected in metastatic thyroid cancer and induces resistance to anoikis in thyroid cancer cell lines. Uniformed Services Pediatric seminar (AAP meeting), Mar 2009. (Ogden-Bruton award finalist, oral presentation).
40.V Vasko, k Jensen, A Patel, A Larin, V Hoperia and A Bauer.
The presence of Human Herpes Virus in thyroid cancer is associated with up-regulation of genes involved in stem cell maintainence. Annual Endocrine Society Meeting, Washington DC, Jun 2009.
41. Jensen K, Patel A, Larin A, Savchenko V, Bauer A, and Vasko V.TREM signaling is activated in Metastatic thyroid cancer cells. American Thyroid Association (ATA meeting), Sep 2009 (poster).
42.Vasyl Vasko, Kirk Jensen,Aneeta Patel,and Andrew Bauer. Detection of herpes simplex viruses.In thyroid cancer. American Thyroid Association meeting, Sept 2009.
43. Kirk Jensen, Aneeta Patel, John Costello, Alexander Larin, Victoria Hoperia, Andrew Bauer,
And Vasyl Vasko. TREM signaling is activated in Metastatic thyroid cancer cells (poster) Research Week , USUHS, May 2010
44. Jensen K, Patel A, Bauer B, Vasko V. HSV2 Infection Targets Thyroid Gland and Affects Expression of DNA Repair Molecules in Thyroid Cells. Endocrine Society Annual Meeting, JUN 2011.
45.Jensen K, Costello J, Patel A, Bauer A, Vasko V. Anoikis in Thyroid Cancer Cells. International Thyroid Congress, SEP 2010 (Winner, Young Investigator Award; poster)
46. Klubo-Gwiezdzinska J, Jensen K, Bauer A, Patel A, Costell J, Burman K, Hardwick M, Vasko V.
“ The expression of translocator protein in human thyroid cancer and its role in the response of thyroid cancer cells to oxidative stress” Carcinogenesis SEP 2010.
47. Jensen K, Costello J, Klubo-Gwiezdzinska J, Patel A, Bauer A, Vasko V “Inhibition of gap junctional transfer confers anoikis susceptibility to thyroid cancer cells”
Endo Related Cancer OCT 2010.
48.Joanna Joanna Klubo-Gwiezdzinska, J Costello Jr., Aneeta Patel, Andrew Bauer,
Kirk Jensen, Mihriye Mete, Kenneth D. Burman, Leonard Wartofsky and Vasyl Vasko. Treatment with Metformin is Associated with Higher Remission Rate in Diabetic Patients with Thyroid Cancer. Endocrine Society Meeting, Jun 2013.
49.Yevgeniya Kushchayeva, John Costello, Aneeta Patel, Erin Felger, Lisa Boyle, Kenneth
Burman and Vasyl Vasko. The HIV protease inhibitor Nelfinavir down-regulates p70S6K/S6 signaling, induce autophagy and apoptosis in thyroid cancer cells. Endocrine Society Meeting, Jun 2013.
50.Anthony Recupero1, Kirk Jensen1, Aneeta Patel1, J Costello Jr.1, Alexander Larin2, Victoria Hoperia2, Yevgeniya Kushchayeva3, Kenneth D. Burman3 and Vasyl Vasko1 Expression of Mitochondrial Respiratory Chain Molecules in Human Medullary Thyroid Cancers, Endocrine Society Meeting, Jun 2014.
51. Joanna Klubo-Gwiezdzinska, MD, PHD, John Costello, Kirk Ernest Jensen, MD, Aneeta Patel, Douglas Van Nostrand, Kenneth Burman, MD, PhD, Leonard Wartofsky, MD, MACP and Vasyl Vasko, MD, PhD. Amifostine Used Clinically for Salivary Gland Protection during Therapy with Radioiodine Is Cytotoxic for Thyroid Cancer Cells. Endocrine Society Meeting, Jun 2014.
52. Anthony Recupero, Kirk Jensen, Aneeta Patel, J Costello Jr., Alexander Larin, Victoria Hoperia, Yevgeniya Kushchayeva, Kenneth D. Burman and Vasyl Vasko. Expression of Mitochondrial Respiratory Chain Molecules in Human Medullary Thyroid Cancers. Endocrine Society Meeting, Jun 2014.
53. Y. Kushchayeva, K. Jensen, J. Costello, A. Patel, K. Burman, and V. Vasko. Autophagy is Implicated in Medullary Thyroid Cancer Cells Response to Treatment with Nelfinavir. American Thyroid Association Meeting. Sept. 2014
54. K. Jensen, A. Patel, K, J. Costello, Y. Kushchayeva, K. Burman and V. Vasko. The Effects of the HIV Protease Inhibitor Nelfinavir on Expression of Mitochondrial Molecules in Medullary Thyroid Cancer Cells. American Thyroid Association Meeting. Sept. 2014.
55.Expression of Organic Cation Transporter 1 (OCT1) in Medullary Thyroid Cancer. A. Bikas, K. Jensen, J. Costello, A. Patel, K. Burman and V. Vasko. American Thyroid Association Meeting, October 2014.
56. A. Bikas, K. Jensen, J. Costello, A. Patel, K. Burman and V. Vasko. Glucose Concentration Underlies the Efficacy of Treatment with Metformin in Thyroid Cancer Cells. Endocrine Society Meeting, March 2015.
57. A. Bikas, K. Jensen, A. Patel, J. Costello, L. Wartofsky, K. Burman, V. Vasko. High Glucose Decreases the Anti-Neoplastic Efficacy of Metformin in Medullary Thyroid Cancer Cells. Endocrine Society Meeting, Apr. 2016.
58. A. Bikas, K. Jensen, A. Patel, J. Costello, R. Tkavc, L. Wartofsky, K. Burman and V. Vasko. The role of autophagy regulator LC3B in thyroid cancer cells response to metabolic stress and radiation. American Thyroid Association Meeting. Oct. 2016
59. A. Bikas, K. Jensen, J. Costello, A. Patel, K. Burman and V. Vasko Mitotane induces mitochondrial membrane depolarization and apoptosis in thyroid cancer cells. Endocrine Society Meeting, Apr. 2017.

Presented Abstracts:

1. Sjogren M, Salata K, Patel A., Billups L.
Hepatitis C virus replication following immunization with influenza vaccine in subjects with chronic HCV infection. Annual Hepatitis Meeting, Athens, Greece, 1996.
2. Dubravec M, Patel A., Hershey J, Salata K.
Effect of leumedin on eosinophil function. Signal Transudation Symposia, 1996.
3. Welch .C, Patel A., Tuttle M, Adair C, Francis G.L.
Oncogene expression in thyroid neoplasia in children in children.
USUHS Research Seminar, 1996.
4. Welch C., Patel A., Salata K, Francis G.L.
Steroid acute regulatory protein Mrna Is transcribed in JEG-3 choriocarcinoma cells. International Congress of Endocrinology, San Francisco CA, June 1996.
5. Francis G.L., Kwun C, Patel A., and Salata K.
Evidence to suggest ceramide might be an important regulator of testicular steroidogenesis.
Semi-finalist, Bruton Award, Uniformed Services Section, American Academy of Pediatrics, San Antonio, TX. March 1997.
6. Kwun C, Patel A., Salata K, Francis G.L.
Ceramide incerases steroid hormone synthesis by MA-10 Murine Leydig Cells.
The Endocrine Society, Minneapolis, MN, June 1997.
7. Kwun C, Patel A., Salata K, Francis G.L.
Ceramide incerases steroid hormone synthesis by MA-10 Murine Leydig Cells.
The Endocrine Society, Minneapolis, MN, June 1997.
8. Fenton C, Lukes Y, Anderson J, Patel A., Welch-Dinauer C, Pletcher S, Tuttle RM, Francis G.L.
N-Ras Mutations in Childhood Thyroid Cancer.
80th Annual Meeting, The Endocrine Society, New Orleans, LA, June 1998.
9. Welch-Dinauer C, Patel A., Fenton C, Tuttle RM, Adair C, Pletcher S, Francis G.L. Apoptosis in Childhood Thyroid Cancer.
80th Annual Meeting, The Endocrine Society, New Orleans, LA, June 1998.
10. Hershey J, Fenton C, Patel A., Welch Dinauer C, Adair C, Pletcher S, Tuttle RM, Francis G.L., Nunez S.
Immunohistochemical detection of p53 in Childhood Thyroid Cancers.
80th Annual Meeting, The Endocrine Society, New Orleans, LA, June 1998.
11. Hershey J, Patel A., Anthoney B, Salata K, Francis G.L.
Sphingomyelinase Regulates Tyrosine Kinase in MA-10 Leydig Cells.
USUHS Research Seminar, April, 1998.
12. Patel A., Hershey J, Anthoney B, Salata K, Francis G.L.
Ceramide regulates Protein Kinase C z in MA-10 Leydig Cells.
USUHS Research Seminar, April, 1998.
13. Patel A., Fenton C., Terrell R., Adair C., Pletcher S., Tuttle R.M., Francis G.L. Detection of Tyrosine Kinase in Childhood Thyroid Cancers.
International Conference on Thyroid Cancer, Linz, Austria, October 7-10, 1998.
14. Wingo S.T., Patel A., Tuttle R.M., Lukes Y.D., Anderson J.S, Djuh Y.Y., Ringel M.D., Balducci P.L, Levine M.A., Francis G.L.
Detection of thyroglobulin mRNA in peripheral blood from normal subjects using a simplified RNA extraction technique.
The Endocrine Society, 1998. Knoll Pharmaceutical Award
15. Patel A., Nicholson D., Hershey J., Salata K., Tuttle R.M., Francis G.L. Gondotrophin stimulation induces mRNA encoding protein kinase C beta 2 in MA-10 leydig cells. Abstract submitted, oral presentation (as requested by meeting coordinators). USUHS Research Seminar, 1998.
16. Ramirez R, Fenton C, Patel A., Dinauer CA, Tuttle RM, Francis G.L.
Over-expression of cMET, is Associated with Increased Recurrence in Childhood Thyroid Cancer.
Society for Pediatric Research, San Francisco, CA, May 1-4, 1999.
17. Fenton C, Patel A., Anderson J, Tuttle R.M., Francis G.L.
Tg-mRNA levels in the peripheral blood of children with benign and malignant thyroid disease: correlation with total body tumor burden.
The Endocrine Society, San Diego, CA, and June 1999.
18. Fenton C, Patel A., Dinauer C, Robie D, Tuttle R.M. Francis G.L.
VEGF expression is directly correlated with size of childhood papillary thyroid cancers and might be associated with increased risk of recurrence.
The Endocrine Society, San Diego, CA, June 1999.
19. Hsu D., Patel A., Fenton C., Dinauer C., Ramirez R., Tuttle R.M. Francis G.L. Scatter Factor expression may induce metastasis of papillary thyroid cancer in children. The Endocrine Society. 1999.
20. Lennard C.M., Patel A., Wilson J, Fenton C, Blair E.A., Francis G.L., Tuttle R.M.
Intensity of vascular endothelial growth factor expression is associated with risk of recurrence as well as recurrence free survival in differentiated thyroid cancer. American Thyroid Association, Palm Beach, FL, October 1999.
21. Welch C, Patel A., Salata K., Francis G.L.
Steroid acute regulatory protein mRNA is transcribed in JEG-3 Choriocarcinoma cells. International Congress of Endocrinology, San Francisco CA, June 1996.
22. Francis G.L., Kwun C., Patel A., Salata K.
Evidence to suggest ceramide might be an important regulator of testicular steroidogenesis.
Semi-finalist, Bruton Award, Uniformed Services Section, American Academy of Pediatrics, San Antonio, TX. March 1997.
23.Kwun C, Patel A., Salata K, Francis G.L.
Cermide increases steroid hormone synthesis by MA-10 Murine Leydig Cells.
The Endocrine Society, Minneapolis, MN, June 1997.
24. Fenton C, Lukes Y, Anderson J, Patel A., Welch-Dinauer C, Pletcher S, Francis G.L.
Apoptosis in Childhood Thyroid Cancer. 80th Annual Meeting,
The Endocrine Society, New Orleans, LA, June 1998.
25. Welch-Dinauer C, Patel A., Fenton C, Tuttle RM, Adair C, Pletcher S, Francis G.L. Apoptosis in Childhood Thyroid Cancer.
80th Annual Meeting, The Endocrine Society, New Orleans, LA, June 1998.
26. Wingo ST, Patel A., Tuttle R.M., Ringel M., Lukes Y., Djuh Y., Anderson J, Dontknow P, Levine M, Francis G.L. Detection of Thyroglobulin (Tg) mRNA in Peripheral Blood From Normal Subjects Using a Simplified Extraction Technique.
80th Annual Meeting, The Endocrine Society, New Orleans, LA, June 1998.
27. Hershey J, Fenton C, Patel A., Welch Dinauer C, Adair C, Pletcher S, Tuttle RM, Francis G, Nunez S.
Immunohistochemical Detection of p53 in Childhood Thyroid Cancers.
80th Annual Meeting, The Endocrine Society, New Orleans, LA, June 1998.
28. Patel A., Hershey J, Anthoney B, Salata K., Francis G.L. Sphingomyelinase Regulates Tyrosine Kinase in MA-10 Leydig Cells. . USUHS Research Seminar, April 1998.
29. Patel A.,Hershey J, Anthoney B, Salata K, Francis G.L.
Ceramide Regulates Protein Kinase C in MA-10 Leydig Cells.
USUHS Research Seminar, April , 1998.
30. Patel A., Fenton C., Terrell R., Adair C., Pletcher S.. Tuttle R.M., Francis G.L. Detection of Tyrosine Kinase in Childhood Thyroid Cancers.
International Conference on Thyroid Cancer, Linz, Austria, October 7-10, 1998.
31. Ramirez R, Fenton C, Patel A., Dinauer C.A., Tuttle R.M., Francis G.L.
Over-expression of cMT, is Associated with Increased Recurrence in Childhood Thyroid Cancer.
Society for Pediatric Research, San Francisco, CA, May 1-4, 1999.
32. Fenton C, Patel A., Anderson J, Tuttle R.M. , Francis G.L.
Tg-mRNA levels in the peripheral blood of children with benign and malignant thyroid disease: correlation with total body tumor burden. The Endocrine Society, Sand Diego, CA, June 1999.
33. Gillespie DL, Patel A, Fileta B, Chang A, Barnes S, Flagg A, Kidwell M, Villavicencio JL, Rich NM. “Variations in protease gene expression in venous insufficiency” Society for Military Vascular Surgeons 19th Annual Vascular Surgery Seminar and Meeting USUHS , Bethesda, MD 12/1999.
34. Gillespie DL, Patel A, Fileta B, Chang A, Barnes S, Flagg A, Kidwell M, Villavicencio JL, Rich NM. “Expression of NMP-1 (latent form) and MMP-13 (latent form) vary by location in incompetent greater saphenous veins” Research Day USUHS Bethesda, MD 3/2000
35. Gillespie DL, Patel A, Fileta B, Chang A, Barnes S, Flagg A, Kidwell M, Villavicencio JL, Rich NM. “Expression of MMP-1 (active form) and MMP-13 (latent form) varies by location in incompetent greater sapenous veins” Association for Academic Surgery, Tampa, Florida, 11/2000
36. Gillespie DL, Patel A, Fileta B, Chang A, Barnes S, Flagg A, Kidwell M, Villavicencio JL, Rich NM. “Expression of MMP-1 (active form) and MMO-13 (latent form) varies by location in incompetent greater saphenous veins”
Society for Military Vascular Surgeons 20th Annual Vascular Surgery Seminar and Meeting USUHS, Bethesda MD 12/2000
37. Gillespie DL, Patel A, Fileta B, Chang A, Barnes S, Flagg A, Kidwell M, Villavicencio JL, Rich NM. “Expression of MMP-1 (active form) and MMP-13 (latent form) are upregulated with worsening venous reflux in patients with venous insufficiency”
Research Day, USUSH,Bethesda, MD 4/2001
38. Gillespie DL, Patel A, Fileta B, Chang A, Barnes S, Flagg A, Kidwell M, Villavicencio JL, Rich NM. “Expression of MMP-1 (active form) and MMP-13 (latent form) are upregulated with worsening venous reflux in patients with venous insufficiency” Society for Investigative Dermatology Washington DC 5/2001
39. Gillespie DL, Patel A, Fileta B, Chang A, Barnes S, Flagg A, Kidwell M, Villavicencio JL, Rich NM. “Expression of MMP-1 and MMP-13 is upregulated with worsening venous reflux in patients with venous insufficiency”
Society for Military Vascular Surgeons 21st Annual Vascular Surgery Seminar and Meeting USUHS, Bethesda MD 12/2001
40. Gillespie DL, Patel A, Fileta B, Chang A, Barnes S, Flagg A, Kidwell M, Villavicencio JL, Rich NM. Expression of MMP-1 and MMP-13 is upregulated with worsening venous reflux in patients with venous insufficiency”. American Venous Forum, La Jolla, CA 2/2002
41. Lennard C.M., Patel A., Wilson J, Fenton C, Blair E.A., Francis G.L.
The Expression of Ki-67 Antigen is Increased in Childhood Thyroid Cancers with Lymph Node Involvement.Semi-Finalist, Johnson Award: Uniformed Services Section, American Academy of Pediatrics, Honolulu, HA, March 14, 2000.
42. Folstad A, Fenton C, Dinauer C, Patel A., Solomon B, Ringel M, Francis G.L. Detection and quantification of thyroglobulin mRNA in the peripheral circulation of adults with benign thyroid disease.
5th Annual Head and Neck International Conference, San Francisco, CA, July 2000.
43. Tuttle R.M., Wingo S., Fenton C., Lukes Y., Patel A., Solomon B., Ringel M, Francis G.L.
Detection and quantification of thyroglobulin mRNA in the peripheral circulation of adults with benign thyroid disease. 5th Annual Head and Neck Internation Conference, San Francisco, CA, June 21-24, 2000.
44. Patel A., Ramirez R., Anderson J., Burch H., Tuttle R.M., Francis G.L. Hepatocyte Growth Factor/ Scatter Factor (HGF/SF) receptor (cMET) mRNA is detected in normal thyroid and thyroid cancers.
82nd Annual Meeting, The Endocrine Society, Toronto, Canada, June 21-24, 2000.
45. Ramirez R, Anderson J, Patel A., Burch H, Tuttle R.M., Francis G.L.
Hepatocyte Growth Factor/ Scatter Factor (HGF/SF) receptor (cMET) mRNA is detected in normal thyroid and thyroid cancers. 82nd Annual Meeting, The Endocrine Society, Toronto, Canada, June 21-24, 2000.
46. Fenton C., Patel A., Tuttle R.M., Francis G.L.
Nuclear Localization of thyroid transcription factor-1 (TTF-1) correlates with serum thyrotropin (TSH) activity in a variety of thyroid disorders.
82nd Annual Meeting, The Endocrine Society, Toronto, Canada, June 21-24, 2000.
47. Tuttle RM, Patel A., Francis G.L., Davis S, Kopecky K.J., Reihardt B.,
Lushnikov E., Abrosimov A., Troshin V., Tsyb A, ,Fenton C.
Vascular endothelial growth factor (VEGF) and type 1 VEGF receptor (flt-1) are highly expressed in Russian papillary thyroid cancers.12th International Thyroid Congress , Kyoto, Japan, October, 2000.
48. Straight A, Duffy E., Patel A., Fenton C, Dinauer C, Tuttle R.M., Francis G.
Inhibitor of matrix metalloproteinase (TIMP-1) is expressed by thyroid carcinomas from children and adolescents. Uniformed Services Section, American Academy of Pediatrics, Louisville, KY March 2001.
49. Duffy E, Straight A, Patel A., Fenton C, Dinauer C, Tuttle R.M., Francis G.L.
Matrix metalloproteinase (MT1-MMP) is expressed by thyroid carcinomas from children and adolescents. Uniformed Services Section, American Academy of Pediatrics, Louisville, KY, March 2001.
50. Straight A, Duffy E, Patel A., Fenton C, Dinauer C, Tuttle R.M., Francis G.L.
Inhibitor of matrix metalloproteinase (TIMP-1) is expressed by thyroid carcinomas from children and adolescents. Uniformed Services Section, American Academy of Pediatrics, Louisville, KY, March 2001.
51. Straight A, Patel A., Fenton C, Dinauer C, Tuttle R.M. Francis G.L.
Thyroid cancers which express telomerase have an increase recurrence risk for children and adolescents. Uniformed Services Section, American Academy of Pediatrics, Louisville, KY, March 2001.
52. Gupta S., Folstad A., Patel A., Fenton C, Dinauer C, Tuttle R.M, Francis G.L.
Infiltration of differentiated thyroid carcinomas by proliferating lymphocytes is associated with improved disease free survival for children and adolescents.
Pediatric Academic Societies, Baltimore, MD, May 2001.
53. Gupta S, Patel A., Jhiang S, Fenton C, Dinauer C, Tuttle R.M., Francis G.L. Sodium iodide symporter expression may indicate a favorable prognosis for thyroid carcinoma of children and adolescents
Pediatric Academic Societies, Baltimore, MD, May 2001.
54. Bauer A, Patel A., Haddad B, Terrell R, Fenton C, Dianuer C, Tuttle R.M. Francis G.L.
The DNA repair enzymes (hMSH-2 and hMLH-1) are expressed in childhood thyroid carcinoma.
Pediatric Academic Societies, Baltimore, MD, May 2001.
55. Shah R., Patel A., Gupta S., Terrell R., Fenton C., Dinauer C., Tuttle R.M.,
Francis G.L. Expression of the antigen presentation co-activator (B7-1) is increased in childhood thyroid carcinoma. Pediatric Academic Societies, Baltimore, MD, May 2001.
56. Straight A., Patel A., Fenton C., Dinauer C., Tuttle R.M. Francis G.L.
Thyroid cancers which express telomerase have an increase recurrence risk for children and adolescents.
Pediatric Academic Societies, Baltimore, MD, May 2001.
57. Gupta S., Patel A., Jhiang S., Fenton C., Dinauer C., Tuttle R.M., Francis G.L. "Sodium-iodide symporter (NIS) expression may indicate a favorable prognosis for papillary thyroid carcinoma".
The Endocrine Society, Denver, CO June 2001.
58. Shah R., Patel A., Gupta S., Terrell R., Fenton C., Dinauer C., Tuttle R.M.,
Francis G.L. The Antigen Presentation Co-Activators (B7-1 and B7-2) are Expressed by Differentiated Thyroid Carcinoma. The Endocrine Society, Denver, CO June 2001.
59. Dobson C., Gupta S., Patel A., Fenton C., Dinauer C., Tuttle R.M., Francis G.L. Papillary thyroid carcinoma from Russian Children Exposed to Radiation Following the Chernobyl Nuclear Accident are more likely to Contain Exposed Radiation Following the Chernobyl Nuclear Accident are more lily to Contain Proliferating Non-Lymphocytic cells.
Lawson Wilkins Pediatrics Endocrine Society, Montreal CA, July 2001.
60. Straight A., Patel A., Fenton C., Dinauer C., Tuttle R.M., Francis G.L.
Thyroid Cancers Which Express Telomerase have an Increased Recurrence Risk for Children and Adolescents. Lawson Wilkins Pediatric Endocrine Society, Montreal CA, July 2001.
61. Scouten W, Patel A, DiLauro R, and Francis G. Cytoplasmic staining for
the paired homeobox gene, PAX-8, suggests a poor prognosis for thyroid carcinoma
of children and adolescents. Uniformed Services Section,
American Academy of Pediatrics, San Diego, CA, March 2002.
62. Bauer A, Patel A, Terrell R, Doniparthi K, Patel A, and Francis G. Treatment of anaplastic thyroid carcinoma xenografts with vascular endothelial growth factor monoclonal antibody is asscoiated with increased wild-type p53 expression. Uniformed Services Section, American Academy of Pediatrics, San Diego, CA, March 2002.
63. Bauer A, Patel A, Ringel M, and Francis G. Angiogenesis in thyroid carcinoma is supported predominantly, and perhaps exclusively, by vascular endothelial growth factor. Uniformed Services Section, American Academy of Pediatrics, San Diego, CA, March 2002.
64. Moores R, Patel A, Park D, Ringel M, and Francis G. A 60 kilodalton phosphotyrosine containing protein is over-expressed by anaplastic thyroid carcinoma and regulated by vascular endothelial growth factor. Uniformed Services Section, American Academy of Pediatrics, San Diego, CA, March 2002.
65. Penko K, Moores R, Patel A, Tuttle RM, Saji M, Ringel M, and Francis G. Anaplastic and differentiated thyroid carcinoma express different profiles of angiogenic stimuli and inhibitors. Predictive Oncology and Intervention Strategies, The Pasteur Institute, Paris, France, February 11, 2002.
66. Modi J, Patel A, and Francis G. Characterization of lymphocytic infiltration in thyroid carcinoma. USUHS Research Day, May 2002.
67. Scouten WT, Patel A, DiLauro R, Tuttle RM, and Francis GL. Cytoplasmic staining for the paired homeobox gene, Pax-8, suggests a poor prognosis for thyroid carcinoma of children and adolescents. The 84th Annual Meeting, The Endocrine Society, San Francisco, CA, June 18-23, 2002.
68. Patel A, Fenton C, Dogra S, Tuttle RM, and Francis GL. Infiltration of differentiated thyroid carcinoma by proliferating lymophocytes is associated with increased expression of the FAS receptor and the Bax pro-apoptotic protein. The 84th Annual Meeting, The Endocrine Society, San Francisco, CA, June 18-23, 2002.
69. Modi J, Patel A, Terrell R, Tuttle RM and Francis G. Childhood thyroid cancers that contain a mixture of lymphocytes have favorable prognostic indicators. Uniformed Services Section, American Academy of Pediatrics, Washington, DC, March 16-19, 2003.
70. Marks R, Patel A, Modi J, Tuttle RM, and Francis G. Are proliferating thyroid cancer associated lymphocytes CD8+ killer cells? Uniformed Services Section, American Academy of Pediatrics, Washington, DC, March 16-19, 2003.
71. Pluim T, Helms A, Patel A, Bauer A, Tuttle RM, and Francis G. An In Vitro study to determine if the novel tumor activated fluropyrimidine carbamate (Capecitabine) could be used to treat thyroid carcinomas. Uniformed Services Section, American Academy of Pediatrics, Washington, DC, March 16-19, 2003.
72. Gydee H, O’Neill JT, Patel A, Tuttle RM and Francis G. Insulin-like growth factor-1 (IGF-1) and the IGF-1 Receptor (IGF-1R) are expressed by childhood thyroid cancers and IGF-1R expression is increased in aggressive tumors. Uniformed Services Section, American Academy of Pediatrics, Washington, DC, March 16-19, 2003.
73. Straight A, Patel A, Bauer A, Saji M, Ringel M, Tuttle RM, and Francis G. Insulin-like growth factor-1 (IGF-1), IGF-2 and the IGF binding protein (IGFBP-5) are differentially expressed by anaplastic and differentiated thyroid cancers. Uniformed Services Section, American Academy of Pediatrics, Washington, DC, March 16-19, 2003.
74. Eccles T, Terrell R, Patel A, Verma A, Tuttle RM and Francis G. Erythropoietin and erythropoietin receptor are expressed by papillary thyroid carcinomas of children and adolescents. Uniformed Services Section, American Academy of Pediatrics, Washington, DC, March 16-19, 2003.
75. Straight A, Patel A, Jimeno J, Tuttle RM, Saji M, Ringel M, and Francis G. Aplidine Reduces in Vivo and in Vitro Growth of Anaplastic Thyroid Cancer. Endocrine Society, Philadelphia, PA, June, 2003.
76. Tyree M, Patel A, O’Neill JT, Tuttle RM, Saji M, Ringel M and Francis G. The Early Growth Response Factor-1 (EGR-1) is Expressed by Poorly Differentiated Thyroid Carcinoma. Endocrine Society, Philadelphia, PA, June, 2003.
77. Bauer AJ, Pluim T, Helms A, Patel A, Tuttle RM, and Francis G. An In Vitro study to determine if the novel tumor activated fluropyrimidine carbamate (Capecitabine) could be used to treat thyroid carcinomas. Endocrine Society, Philadelphia, PA, June, 2003.
78. Eccles T, Patel A, Verma A, Nicholson D, Tuttle RM and Francis G. Erythropoietin (EPO) and the EPO Receptor (EPO-R) are Expressed by Papillary Thyroid Carcinomas and Expression of EPO-R is a Favorable Prognostic Indicator. Endocrine Society, Philadelphia, PA, June, 2003.
79. Straight AM, Patel A, Bauer A, Terrell R, Helms A, Tuttle M, Jimeno J, Saji M, Ringel M, and Francis G. Aplidine Reduces Angiogenic Gene Expression and Increases PARP Hydrolysis in Anaplastic Thyroid Cancer Xenografts. AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, MA, November 2003
80. Straight A, Bauer A, Oakley K, Patel A, Scouten W, Tuttle RM, Jimeno J, and Francis G. Aplidine Reduces in Vitro Growth and the Expression of Angiogenic Genes by Medullary Thyroid Cancer (MTC). Finalist Ogden Bruton Competition, Uniformed Services Section, American Academy of Pediatrics, Seattle, WA March 2004.
81. Costello A, Rey-Hipolito C, Patel A, Tuttle RM and Francis G. Childhood Thyroid Cancers that Express CD-40 Ligand have a Greater Risk of Recurrence. Semi-Finalist Howard Johnson Competition, Uniformed Services Section, American Academy of Pediatrics, Seattle, WA March 2004.
82. Patel A, Oakley K, Tuttle RM, Francis G. Differential In Vitro Expression of Caspase 7 by Thyroid Carcinoma Cell Lines. The Endocrine Society, New Orleans, LA, June 2004.
83. Francis G, Costello A, Rey-Hipolito C, Tuttle RM, Saji M, Ringel RM, Patel A. CD-40 and CD-40 Ligand Are Differentially Expressed In Vitro by Thyroid Cancer Cell Lines. The Endocrine Society, New Orleans, LA, June 2004
84. Moores R, Oakley K, Patel A, Bauer A, Saji M, Ringel M, Tuttle RM, Francis G. Serum-Deprivation Up-Regulates In Vitro Expression of Multiple Angiogenic Genes in Thyroid Cancer Cells. The Endocrine Society, New Orleans, LA, June 2004.
85. Adly M, Moores R, Patel A, Jacobowitz D, Ji X, Jiang G, Datta R, Jozwik C, Tuttle RM, Francis G. Unique Patterns of In Vitro Protein Expression Are Revealed by by 2-Dimensional Gel Electrophoresis and Vary between Papillary and Anaplastic Thyroid Cancer Cell Lines. The Endocrine Society, New Orleans, LA, June 2004.
86. Torosyan Y, Patel A, Straight A, Oakley K, Moores R, Tuttle RM, Francis G. In Vitro Expression of Vascular Endothelial Growth Factor Receptor 2 (flk 1 / KDR) Is Induced by Serum Deprivation of Papillary Thyroid Cancer Cells (NPA). The Endocrine Society, New Orleans, LA, June 2004.
87. Francis G, Patel A, Oakley K, Bauer A, Vasco V, and Milroy K. Differential In Vitro Expression of Anti-Apoptotic Peptides in Anaplastic, Follicular and Papillary Thyroid Cancers. Uniformed Services Section, American Academy of Pediatrics, San Antonio TX, March 2005.
88. Milroy K, Patel A, Torosayan Y, Oakley K, Vasco V and Francis G. In Vitro 5-Lipoxygenase Expression Differs Between Papillary, Follicular and Anaplastic Thyroid Cancers. Uniformed Services Section, American Academy of Pediatrics, San Antonio TX, March 2005.
89. MacKenzie E, Patel A, Oakley K, Jensen K, Scouten W, Vasco V, and Francis G. DNA Methyltransferase Expression Is Increased In Thyroid Cancer Cells That Have Undergone Epithelial-Mesenchymal Transition. Uniformed Services Section, American Academy of Pediatrics, San Antonio TX, March 2005. Recipient Val Hemming Research Award.
90. Scouten W, Patel A, Vasco V, and Francis G. STAT-5 is Expressed by Papillary Thyroid Carcinoma of Children and Adolescents and the Intensity of Expression is Correlated with Patient Age. Uniformed Services Section, American Academy of Pediatrics, San Antonio TX, March 2005.
91. Yates C, Patel A, Oakley K, and Francis G. Erythropoietin Increases the In Vitro Expression of Epidermal Growth Factor Receptor (EGF-R) in Anaplastic Thyroid Carcinoma. Uniformed Services Section, American Academy of Pediatrics, San Antonio TX, March 2005.
92. Yates C, Patel A, Oakley K, and Francis G. Erythropoietin Expression by Thyroid Carcinoma is Increased by In Vitro Treatment with Insulin Like Growth Factor-1 (IGF-1). Uniformed Services Section, American Academy of Pediatrics, San Antonio TX, March 2005
93. Jensen K, Patel A, Oakley K, Murray C, Bauer A, Vasko V, Francis G.
In Vitro DNA Methyltransferase expression by Thyroid Cancer. Pediatric Academic Society, May 2005.
94. Jensen K, Mackenzie E, Vasko V, Patel A, Oakley K, Saji M, Ringel M, Francis G.
Expression of DNA Methyltransferase varies among Thyroid Tumors and according to the extent of disease for papillary Thyroid Carcinomas. Endocrine Society Annual Meeting, Jun 2005 .
95. Jensen K, Patel A, Bauer A, Saji M, Vasko V. Treatment with DNA methylation inhibitors induce differentiation but may also induce expression of genes involved in Epithelial- Mesenchymal transition. American Thyroid Association Annual Meeting, Oct 2006.
96. Jensen K, Patel A, Bauer A, Vasko V. Targeting of epigenetic regulators in Thyroid cancer. Uniformed Services Pediatric Seminar ( AAP meeting), Mar 2007.
97. Jensen K, Patel A, Kuehn D, Bauer A, Vasko V. E-Cadherin gene promoter methylation in Papillary Thyroid Cancer and in lymph node metastases. Endocrine Society Annual Meeting, Jun 2007.
98. Jensen K, Patel A, Bauer A, Vask V. Thyroid cancer invasion and metastases: The role of Epithelial –Mesenchymal Transition. Bailey K Ashford competition, April 2007
99. Jensen K, Patel A, Bauer A, Vasko V. Epigenetic regulation of Oct-4 expression in thyroid papillary cancer and lymph node metastases. American Thyroid Association Annual meeting, Oct 2007.
100. Jensen K, Patel A, Bauer A, Vasko V. Anti-angiogenesis treatment activates notch signaling in thyoid cancer cells. American Thyroid Association Annual meeting, Oct 2008 .
101. Jensen K, Patel A, Larin A, Savchenco V, Bauer A,Yim K, Vasko V.
Human herpes virus is frequently detected in metastatic thyroid cancer and induces resistance to anoikis in thyroid cancer cell lines. American Thyroid Association Annual meeting, Oct 2008.
102. Jensen K, Patel A, Larin A, Savchenco V,Bauer A, Yim K, Vasko V. Human herpes virus is frequently detected in metastatic thyroid cancer and induces resistance to anoikis in thyroid cancer cell lines. Uniformed Services Pediatric seminar (AAP meeting), Mar 2009. (Ogden-Bruton award finalist, oral presentation).
103.V Vasko, k Jensen, A Patel, A Larin, V Hoperia and A Bauer.
The presence of Human Herpes Virus in thyroid cancer is associated with up-regulation of genes involved in stem cell maintainence. Annual Endocrine Society Meeting, Washington DC, Jun 2009.
104. Jensen K, Patel A, Larin A, Savchenko V, Bauer A, and Vasko V.TREM signaling is activated in Metastatic thyroid cancer cells. American Thyroid Association (ATA meeting), Sep 2009 (poster).
105.Vasyl Vasko, Kirk Jensen,Aneeta Patel,and Andrew Bauer. Detection of herpes simplex viruses.In thyroid cancer. American Thyroid Association meeting, Sept 2009.
106. Kirk Jensen, Aneeta Patel, John Costello, Alexander Larin, Victoria Hoperia, Andrew Bauer,
And Vasyl Vasko. TREM signaling is activated in Metastatic thyroid cancer cells (poster) Research Week , USUHS, May 2010
107. Jensen K, Patel A, Bauer B, Vasko V. HSV2 Infection Targets Thyroid Gland and Affects Expression of DNA Repair Molecules in Thyroid Cells. Endocrine Society Annual Meeting, JUN 2011.
108.Jensen K, Costello J, Patel A, Bauer A, Vasko V. Anoikis in Thyroid Cancer Cells. International Thyroid Congress, SEP 2010 (Winner, Young Investigator Award; poster)
109. Klubo-Gwiezdzinska J, Jensen K, Bauer A, Patel A, Costell J, Burman K, Hardwick M, Vasko V.
“ The expression of translocator protein in human thyroid cancer and its role in the response of thyroid cancer cells to oxidative stress” Carcinogenesis SEP 2010.
110. Jensen K, Costello J, Klubo-Gwiezdzinska J, Patel A, Bauer A, Vasko V “Inhibition of gap junctional transfer confers anoikis susceptibility to thyroid cancer cells”
Endo Related Cancer OCT 2010.
111.Joanna Joanna Klubo-Gwiezdzinska, J Costello Jr., Aneeta Patel, Andrew Bauer,
Kirk Jensen, Mihriye Mete, Kenneth D. Burman, Leonard Wartofsky and Vasyl Vasko. Treatment with Metformin is Associated with Higher Remission Rate in Diabetic Patients with Thyroid Cancer. Endocrine Society Meeting, Jun 2013.
112.Yevgeniya Kushchayeva, John Costello, Aneeta Patel, Erin Felger, Lisa Boyle, Kenneth
Burman and Vasyl Vasko. The HIV protease inhibitor Nelfinavir down-regulates p70S6K/S6 signaling, induce autophagy and apoptosis in thyroid cancer cells. Endocrine Society Meeting, Jun 2013.
113.Anthony Recupero1, Kirk Jensen1, Aneeta Patel1, J Costello Jr.1, Alexander Larin2, Victoria Hoperia2, Yevgeniya Kushchayeva3, Kenneth D. Burman3 and Vasyl Vasko1 Expression of Mitochondrial Respiratory Chain Molecules in Human Medullary Thyroid Cancers, Endocrine Society Meeting, Jun 2014.
114. Joanna Klubo-Gwiezdzinska, MD, PHD, John Costello, Kirk Ernest Jensen, MD, Aneeta Patel, Douglas Van Nostrand, Kenneth Burman, MD, PhD, Leonard Wartofsky, MD, MACP and Vasyl Vasko, MD, PhD. Amifostine Used Clinically for Salivary Gland Protection during Therapy with Radioiodine Is Cytotoxic for Thyroid Cancer Cells. Endocrine Society Meeting, Jun 2014.
115. Anthony Recupero, Kirk Jensen, Aneeta Patel, J Costello Jr., Alexander Larin, Victoria Hoperia, Yevgeniya Kushchayeva, Kenneth D. Burman and Vasyl Vasko. Expression of Mitochondrial Respiratory Chain Molecules in Human Medullary Thyroid Cancers. Endocrine Society Meeting, Jun 2014.
116. Y. Kushchayeva, K. Jensen, J. Costello, A. Patel, K. Burman, and V. Vasko. Autophagy is Implicated in Medullary Thyroid Cancer Cells Response to Treatment with Nelfinavir. American Thyroid Association Meeting. Sept. 2014
117. K. Jensen, A. Patel, K, J. Costello, Y. Kushchayeva, K. Burman and V. Vasko. The Effects of the HIV Protease Inhibitor Nelfinavir on Expression of Mitochondrial Molecules in Medullary Thyroid Cancer Cells. American Thyroid Association Meeting. Sept. 2014.
118.Expression of Organic Cation Transporter 1 (OCT1) in Medullary Thyroid Cancer. A. Bikas, K. Jensen, J. Costello, A. Patel, K. Burman and V. Vasko. American Thyroid Association Meeting, October 2014.
119. A. Bikas, K. Jensen, J. Costello, A. Patel, K. Burman and V. Vasko. Glucose Concentration Underlies the Efficacy of Treatment with Metformin in Thyroid Cancer Cells. Endocrine Society Meeting, March 2015
120. A. Bikas, K. Jensen, A. Patel, J. Costello, L. Wartofsky, K. Burman, V. Vasko. High Glucose Decreases the Anti-Neoplastic Efficacy of Metformin in Medullary Thyroid Cancer Cells. Endocrine Society Meeting, Apr. 2016.
121. A. Bikas, K. Jensen, A. Patel, J. Costello, R. Tkavc, L. Wartofsky, K. Burman and V. Vasko. The role of autophagy regulator LC3B in thyroid cancer cells response to metabolic stress and radiation. American Thyroid Association Meeting. Oct. 2016
122. A. Bikas, K. Jensen, J. Costello, A. Patel, K. Burman and V. Vasko Mitotane induces mitochondrial membrane depolarization and apoptosis in thyroid cancer cells. Endocrine Society Meeting, Apr. 2017.


Oral Presentations:

Salata K.F., Dubravec M., Patel A., Francis G.L., Hershey J.N.
"EGF-stimulated tyrosine kinase activity by flow cytometry."
USUHS, Sanford Auditorium 1999

“VEGF is expressed in the majority of Childhood Papillary Thyroid Cancers, directly related tumor sizes and may be associated with an increased risk of Recurrence”.
Jensen K, Patel A, Bauer A, Vask V. Thyroid cancer invasion and metastases: The role of Epithelial –Mesenchymal Transition. Bailey K Ashford competition, April 2007
(WRAMC-Oral presentation).

Jensen K, Patel A, Larin A, Savchenco V,Bauer A, Yim K, Vasko V. Human herpes virus is frequently detected in metastatic thyroid cancer and induces resistance to anoikis in thyroid cancer cell lines. Uniformed Services Pediatric seminar (AAP meeting), Mar 2009. (Ogden-Bruton award finalist, oral presentation).
Anthony Recupero1, Kirk Jensen1, Aneeta Patel1, J Costello Jr.1, Alexander Larin2, Victoria Hoperia2, Yevgeniya Kushchayeva3, Kenneth D. Burman3 and Vasyl Vasko1 Expression of Mitochondrial Respiratory Chain Molecules in Human Medullary Thyroid Cancers, Endocrine Society Meeting, Jun 2014—Oral Presentation

Technical Report:

1. Patel A., Smith K.G., Cooley J., Francis G.L.
A fluorescent gel-shift essay for the determination of nuclear DNA-binding proteins. Am Biotechnol Lab, 15:19-20, 1997.

Publications in Peer reviewed Journals:
1. Tsokos G.C., Stizel A.E.,Patel A., Hiramatsu M., Balow J.E. , SptizerR.E. Human polyclonal and monoclonal IgG and IgM complement 3 nephritic Factor: Evidence for idiotypic commonality. Clin.Immunol.Immunopathol 1989, 53:113-122
2. Tsokos G.C., Kinoshita T., Thypronitis G., Patel A., Dickler H.B., Finkleman F.D.,Interactions between murine B lymphocyte surface membrane molecules: loaded but not free receptors for complement and the Fc Portion of IgG co-cap independently with cross-linked surface immunoglobulin. J Immunol 1990 144: 239-243
3. Ting C, Hargrove M.E., Wang J., Patel A. Differential requirement of protein kinase C and protein tyrosine kinase in generation of IL2 induced LAK cells and anti CD3 induced CD3AK cell response. Cell Immunol. 1994, 160:286-296
4. Peten E.P., Striker L.J., Fogo A., Ichikawa L., Patel A., Striker G.E. The molecular basis of increased glomerulosclerosis after blockade of the renin angiotensin system in growth hormone transgenic mice. Mol Med 1994 VI Num1, 1-12
5. He C.J, Yang C.W., Peten E.P, LIU Z.H., Patel A., Striker L.J, Striker G.E.
Collagen and collagenase mRNAs in normal and sclerotic glomeruli: Predictors of progression and response to therapy. Kidney Int Suppl. 1994, Jun, 49: S39-43
6. Liu Z.H., Sahl P.D., Striker L.J., Patel A., He C.J , Striker G.E.
Interleukin-1 alpha and tumor necrosis factor alpha induce mannose receptor expression in glomerular mesangial cells. Kidney Int, Suppl. 1995 Sep; S37-8
7. Esposito C, Patel A., Liu Z.H, Striker G, Striker L.J.
Involvement of synthesis and degradation pathways of collagen type IV in human glomerulosclerosis: molecular analysis by in situ reverse transcription and competitive polymerase chain reaction. Contrib. Nephrol. 1996, 118:12-16.
8. Esposito C., Striker L.J., Patel A., Peten E., Liu Z.H., Sakai H., Striker G.E.
The International study group For molecular study of kidney biopsies: Initial results of a collaborative international study. Proc of Asso of Amer Physi. 1996,V 108, Number 3, 209-217
9. Liu Z.H,. Striker G.E, Stetler-Stevenson M, Fukushima P, Patel A., Striker L.J. TNF-alpha and IL-1 alpha induce mannose receptors and apoptosis in glomerular mesangial but not endothelial cells. Am .J Physio, 1996, Jun, 270(6 Pt 1): C1595-601
10. Austin H., Patel A., Cadena C.A., Boumpas D.T., Balow J.E.
Ongoing Immunologic activity after short courses of pulse cyclophophamide in the NZB/W murine model of SLE. J Rheumotol 1997, Jan; 24(1): 61-8
11. Kovacs B.,Patel A., Hershey J., Dennis G., Kirschfink M., Tsokos G.C.
Antibodies against P53 in sera from patients with systemic lupus erythematosus and other rheumatic diseases. Arthritis and Rheumatism. 1997, May; 40(5): 980-2
12. Dinauer CA, Patel A., McClellan DR, Salata K, Francis G.
The ceramide pathway Increases cholesterol mobilization and steroidogenic acute regulatory protein mRNA. Endocrinol Metab, 1997,4:385-391
13. Kwun C, Patel A., Pletcher S, Lyons B, Salata K and Francis G.
Ceramide affects steroid hormone production in MA-10 Leydig cells. Steroids, 1999, 64:499-509
14. Wingo ST, Ringel MD, Anderson JS, Patel A, Lukes YD, Djuh YY, Solomon B, Nicholson D, Balducci-Silano PL, Levine MA, Francis GL, Tuttle RM.
Quantitative RT-PCR measurement of thyroglobulin mRNA in peripheral blood of normal subjects. Clin Chem, 1999, 45:785-789
15. Patel A., Fenton C, Welch Dinauer C, Tuttle RM, and Francis G.
Tyrosine Kinase is overexpressed by Papillary Thyroid Carcinoma in children and young Adults. Frontiers in Bioscience, 2000, : a1-9
16. Ramirez R, Hsu,D, Patel A., Fenton C.,Welch Dinauer C, Tuttle RM, Francis GL. Over-expression of hepatocyte growth factor (HGF/SF) and the HGF/SF receptor (cMET), are associated with a high risk of metastasis and Recurrence for young adults with papillary thyroid carcinoma.
Clin Endocrinol, 2000, 53:635-644
17. Fenton C, Patel A., Lukes Y, Dinauer CA, Robie D, Tuttle RM, Francis GL.
The expression of vascular endothelial growth factor (VEGF) and the type 1 VEGF receptor (FLT-1) are associated with growth of papillary thyroid cancer in children and young adults.
Thyroid , 2000, 10:349-357
18. Fenton C, Patel A., Tuttle RM, Francis GL.
P53 Autoantibodies can be detected in the sera of patients with autoimmune thyroid disease. Ann Clin Lab Sci, 2000, 30:179-183
19. Gillespie DL, Patel A Fileta B, Chang A, Barnes S, Flagg A, Villavicencio JL, Rich NM.
Varicose veins possess greater quantities of MMP-1 than normal veins and demonstrate regional variations in MMP-1 and MMP-13. J.Surg Res 2002 Aug; 106 (2):233-5.
20. Fenton C, Anderson J, Patel A., Lukes Y , Solomon B , Tuttle RM, Ringel MD,
Francis G.L. Thyroglobulin messenger ribonucleic acid levels in the peripheral blood of
children with benign and malignant thyroid disease. Pediatr Res , 2001, 49 :429-434
21. Lennard CM, Patel A., Wilson J, Tuman C, Fenton C, Blair EA, Francis G.L.,
Tuttle RM Intensity of vascular endothelial growth factor expression is associated with
increased risk of recurrence and reduced disease free survival in papillary thyroid
cancer. Surgery, 2001, 129(5): 552-558
22. Gupta S, Patel A., Folstad A, Fenton C, Dinauer C,Tuttle RM, Conran R,
Francis G.L. Infiltration of differentiated thyroid carcinoma by proliferating lymphocytes is
associated with improved disease-free survival for children and young adults.
J Clin Endocrinol Metab, 2001, 86: 1072-1077
23. Fenton C, Patel A., Burch H., Tuttle RM, Francis G.
Nuclear localization of thyroid transcription factor-1 carrelates with serum thyrotropin activity and may be increased in differentiated thyroid carcinoma with aggressive clinical course for children and adolescents. Ann Clin Lab Sci, 2001, 31: 245-252
24. Patel A., Straight AM, Mann H, Duffy E, Fenton C, Dinauer C, Tuttle RM ,
Francis G.L. Matrix metalloproteinase expression by differentiated thyroid carcinoma of
children and adolescents. J Endocrinol Invest, 2002, May25 (5) 403-8
25. Shah R, Banks K, Patel A., Dogra S, Terrell R, Powers P, Fenton C, Dinauer C, Tuttle RM, and Francis G, Intense Expression of the B7-2 antigen presentation co-activator is an unfavorable prognostic indicator for differentiate thyroid carcinoma of children and adolescents.
J Clin Endocrinol Metab, 2002, 87(9) 4391-4397
26. Straight A, Patel A., Fenton C, Dinauer C, Tuttle RM ,Francis G.L.
Thyroid carcinomas that express telomerase follow a more aggressive clinical course for children and adolescents. J Endocrinol Invest 2002, 25:302-308.
27. Gillespie D, Patel A., Fileta B, Chang A, Barnes s, Flagg A, Kidwell M, Villavicencio J, Rich N.
Varicose Veins Possess Greater Quantities of MMP-1 Than Normal Veins and Demonstrate Regional Variation in MMP-1 and MMP-13. JSurg Res. 2002 Aug;106(2):233-238.
28. A.Patel, C.Fenton, R.Terrell, P.A.Powers, C.Dinauer, R.M.Tuttle,and G.L.Francis
Nitrotyrosine, inducible nitric oxide synthase (iNOS), and endothelial nitric oxide synthase (eNOS) are increased in thyroid tumors from children and adolescents.
J.Endocrinol.Invest. 2002, 25:675-683
29. Aneeta Patel , Sissy Jhiang, Shalini Dogra, Richard Terrell, Patricia A.Powers,
Cydney Fenton, Catherine A.Dinauer, R.Michael Tuttle and Gary L. Francis
Differentiated Thyroid Carcinoma That Express Sodium-Iodide Symporter Have a Lower Risk of Recurrence for Children and Adolescents Pediatric Research, 2002, 52:737-744.
30. Andrew J.Bauer, Richard Terrell, Nalinikrishna K. Doniparthi, Aneeta Patel, R.Michael Tuttle, Motoyasu Saji, Matthew D. Ringel, Gary L.Francis
Vascular Endothelial Growth Factor Monoclonal Antibody (VEGF-MAb) Inhibits Growth Of Anaplastic Thyroid Cancer Xenografts In Nude Mice
Thyroid, 2002 Nov;12 (11) 953-961.
31. Bauer AJ, Patel A, Terrell R, Doniparthi K, Saji M, Ringel M, Tuttle RM and Francis G. Vascular endothelial growth factor monoclonal antibley (VEGF-MAb) inhibits growth of papillary thyroid cancer xenografts. Ann Clin and Lab Science,2003, 33:192-199.
32. Modi J, Patel A, Terrell R, Gupta S, Fenton C, Tuttle RM and Francis G. Papillary Thyroid Carcinoma from Children and Adolescents Contain a Mixture of Lymphocytes. J Clin Endocrinol Metab, 2003, 88:4418-4425.
33. Eccles TG, Patel A, Verma A, Nicholson D, Lukes Y, Tuttle RM and Francis G. Erythropoietin and the Erythropoietin Receptor are Expressed by Papillary Thyoid Carcinoma from Children and Adolescents. Expression of Erythropoietin Receptor Might be a Favorable Prognostic Indicator. Ann Clin and Lab Science, 2003, 33(4):411-422.
34. Patel A, Pluim T, Helms A, Bauer A, Tuttle RM, and Francis GL. Enzyme Expression Profiles Suggest The Novel Tumor-activated Fluoropyrimidine Carbamate Capecitabine (Xeloda) Might be Effective Against Papillary Thyroid Cancers of Children and Young Adults. Cancer Chemother Pharmacol, 2004 May;53 (5):409-14.
35. Gydee H, O’Neill JT, Patel A, Bauer AJ, Tuttle RM, and Francis GL. Differentiated Thyroid Carcinomas from Children and Adolescents Express Insulin-lIke Growth Factor-1 (IGF-1) and the IGF-1 Receptor (IGF-1-R). Cancers with the most Intense IGF-1-R Expression may be More Aggressive. Pediatr Res, 2004; 55(3):1-7.
36. Scouten W, Patel A, DiLauro R, and Francis G. Cytoplasmic staining for the paired homeobox gene, PAX-8, suggests a poor prognosis for thyroid carcinoma of children and adolescents. Thyroid, 2004;14(12):1037-46.
37. Costello A, Rey-Hipolito C, Patel A, Tuttle RM and Francis G. Childhood
Thyroid Cancers Express CD-40 and CD-40 Ligand. Cancers that Express
CD-40Ligand have a greater Risk of Recurrence. Thyroid, 2005;15(2):105-113.
38. Straight A, Oakley K, Moores M, Bauer AJ, Patel A, Tuttle RM, Jimeno J,
Francis GL. Aplidine Reduces Growth of Anaplastic Thyroid Cancer
Cancer Chemother Pharmacol, 2006 Jan 57(1)7-14.
39. Penko K, Livezey J, Fenton C, Patel A, Nicholson D, Flores M, Oakley K, Tuttle RM, Francis GL. BRAF Mutations are Uncommon in Papillary Thyroid Cancer (PTC) of Young Patients. Thyroid,2005 April 15(4)320-5.
40.Gilliam LK, Kohn AD, Lalani T, Swanson PE,Vasko V, Patel A, Livingston RB, Pickett CA. Capecitabine therapy for refractory metastatic thyroid carcinoma: a case series. Thyroid, 2006 Aug;16 (8)801-10.
41. Jensen K, Patel A, Larin A, Hoperia V, Saji M, Hemming V, Vasko V.Human Herpes simplex viruses in benign and malignant thyroid tumors. J Pathol,2010 Jun;221(2): 193-200.
42. Jensen K, Costello J, Klubo-Gwiezdzinska J, Patel A, Bauer A, Vasko V. Inhibition of gap junctional transfer confers anoikis susceptibility to thyroid cancer cells. Endo Related Cancer, 2011 Sept; 18 (5):613-26.
43. Aneeta Patel, Joanna Klubo-Gwiezdzinska, Victoria Hoperia, Alexander Larin, Kirk Jensen, Andrew Bauer, Vasyl Vasko. BRAF (V600E) Mutation Analysis from May-Grunwald Giemsa-Stained Cytological Samples as an Adjunct in Identification of High Risk Papillary Thyroid Carcinoma. Endocrine Pathology, 2011, Sept; 22 (4):195-9.
44.Klubo-Gwiezdzinska J, Jensen K, Bauer A, Patel A, Costell J, Burman K, Hardwick M, Vasko V. The expression of translocator protein in human thyroid cancer and its role in the response of thyroid cancer cells to oxidative stress. J.Endocrinol 2012 Aug;214 (2):207-16.
45.Klubo-Gwiezdzinska J, Jensen K, Costello J, Patel A, Hoperia V, Bauer A, Burman K, Wartofsky L, Vasko V. Metformin Inhibits Growth and Decreases Resistance to Anoikis in Medullary Thyroid Cancer Cells. Endocr Relat Cancer. 2012 May 24;19(3):447-56.
46. Klubo-Gwiezdzinska J, Jensen K, Bauer A, Patel A, Costello J, Burman K, Hardwick M, Vasko V.
The Expression of Translocator Protein in Human Thyroid Cancer and its Role in the Response of Thyroid Cancer Cells to Oxidative Stress. J.Endocrinol 2012 Aug;214 (2):207-16.
47.Klubo-Gwiezdzinska J, Costello J Jr, Patel A, Bauer A, Jensen K, Mete M, Burman KD, Wartofsky L, Vasko V. Treatment with Metformin is Associated with Higher Remission Rate in Diabetic Patients with Thyroid Cancer. J Clin Endocrinol Metab. 2013 Aug;98 (8):3269-79.
48. Kushchayeva Y, Jensen K, Recupero A, Costello J, Patel A, Klubo-Gwiedzinska J, Boyle L, Burman K, Vasko V. The HIV Protease Inhibitor Nelfinavir Downregulates RET Signaling and Induces Apoptosis in Medullary Thyroid Cancer Cells. J Clin Endocrinolgy Metab. 2014 Jan;99 (5):E734-45.
49. Bikas A, Jensen K, Patel A, Costello J, McDaniel D, Klubo-Gwiezdzinska J, Larin O, Hoperia V, Burman K, Boyle L, Wartofsky L, Vasko V. Glucose-deprivation increases thyroid cancer cell sensitivity to metformin. Endocr Relat Cancer. 2015 Sep; 11(22):919-932.
50. Bikas A, Van Nostrand D, Jensen K, Desale S, Mete M, Patel A, Wartofsky L, Vasko V, Burman KD. Metformin Attenuates (131)I-Induced Decrease in Peripheral Blood Cells in Patients with Differentiated Thyroid Cancer. Thyroid. 2016 Feb; 26(2):280-6.
51. Jensen K, Bikas A, Patel A, Kushchayeva Y, Costello J, McDaniel D, Burman K, Vasko V. Nelfinavir inhibits proliferation and induces DNA damage in thyroid cancer cells. Endocr Relat Cancer. 2017 Mar;24(3):147-156.

USUHS GRANTS:
Starter Grant, Project Number CO86DW
“ Vascular Endothelial Growth Factor (VEGF) Isoforms in Thyroid cancer”.
Funded from May 2000 – June 2001.

Standard Grant, Project Number CO86EF-01
“ Vascular Endothelial Growth Factor (VEGF) Isoforms in Thyroid Cancer”.
Funded from April 2001 – September 2003.

Department funded Pediatrics research grant, Project Number: QP86GI-S25
“Targeting Metabolic Signaling in Medullary Thyroid Cancer.
Funded from June 2014-September 2015.

Unfunded:
Proposal # G186FO 2002
“ Regulation of Apoptosis in Thyroid Carcinoma”.

Proposal # G186F1 2003
“ Regulation of Apoptosis in Thyroid Carcinoma”.

Extramural Funding from Hope Street Kids 2003
“ Insulin like Growth Factors in Thyroid Cancer”.

OTHER GRANTS (COLLABORATION)
The Role of Tyrosine Kinases and Their Substrates in Thyroid Cancer (AI, 10%)
$20,000, 2002 – 2004, USUHS, Office of Research, Current; Prof.Gary L.Francis M.D.Ph.D.; Fellows: William Scouten, MD, Catherine Yates, MD, Ann Straight, MD

The Role of Insulin-Like Growth Factors in Thyroid Cancer (AI, 10%) $7,500,
2001 –2004, DCI, WRAMC, Current; Prof.Gary L.Francis M.D., Ph.D.; Fellows: Ann
Straight, MD

Characterization of Lymphocytic Infiltration in Childhood Thyroid Cancers (AI, 10%)
$7,500, DCI, WRAMC, 2001-4, Current; Prof.Gary L. Francis M.D.,Ph.D.; Residents: Jitu Modi, MD, Pediatrics, WRAMC

The Role of Erythropietin and Erythropoietin Receptor in Thyroid Cancer (AI, 10%)
$7,500, DCI, WRAMC, 2001-4, Current; Prof.Gary L.Francis M.D., Ph.D.; Residents: Tom Eccles, MD, Pediatrics, WRAMC

Preclinical Data to Determine if the Tumor-Activated Fluoropyrimidine Carbamate
(Capecitabine) Could be Used in Treatment of Thyroid Cancer (AI, 10%) $7,500, DCI, WRAMC, 2001-4, Current; Prof.gary L.Francis M>D.,Ph.D.; Students: Tom Pluim, USUHS

The Effect of Aplidine of Thyroid Cancer Xenografts in Nude Mice (AI, 10%)
$7,500, Endocrine Fellow’s Foundation, TRAC, 2001-4, Current; Prof.Gary L.Francis M.D.,Ph.D.; Fellows: Ann Straight, MD

(AI) Protein Expression and Phosphorylation in Thyroid Cancer
Gary Francis, MD, PhD: United States Military Cancer Institute, 2003, $50,000

(AI) Angiogenic Gene Expression in Thyroid Cancer
Russ Moores, MD: Pharmacia Corporation, 2003, $50,000

(AI) Protein Expression and Phosphorylation in Thyroid Cancer
Gary Francis, MD, PhD: Thrasher Foundation, 2003, $30,000

(PI) Apoptosis in Thyroid Cancer
USUHS, Office of Research, 2003, $16,200

(PI) Apoptosis in Thyroid Cancer
Pharmacia Corporation, 2003, $50,000

(AI) PAX-8 Expression in Thyroid Cancer
Bill Scouten, MD: Endocrine Fellow’s Foundation, 2003, $7,500

(AI) Angiogenic Gene Expression in Thyroid Cancer
Russ Moores, MD: Hope Street Kids, 2003, $50,000

(PI) Insulin Like Growth Factors in Thyroid Cancer
Hope Street Kids, 2003, $50,000

(PI) Apoptosis in Thyroid Cancer
USUHS, Office of Research, 2002, $16,200

(PI) Apoptosis in Thyroid Cancer
Thyroid Research Advisory Council, 2002, $30,000

(PI) Expression of neurofilament light polypeptide in medullary thyroid cancer cells.
Allison Wessner, Visiting resident physician-r