Angela R. Melton-Celsa

Ph.D.

Department of Primary Appointment:
School of Medicine
Microbiology and Immunology
Location: Uniformed Services University of the Health Sciences, Bethesda, MD
Research Interests:
Toxins, Diagnostics, and Therapies, biofilm
Basic Biology of Bacterial, Viral, or Parasite Diseases
Office Phone

Education

BS, Loyola Marymount University
Ph.D. Virginia Commonwealth University, Medical College of Virginia

Representative Bibliography

Russo LM, Melton-Celsa AR, O'Brien AD. Shiga Toxin (Stx) Type 1a Reduces the Oral Toxicity of Stx Type 2a. J Infect Dis. 2016 Apr 15;213(8):1271-9.

Melton-Celsa AR, O'Brien AD, Feng PC. Virulence Potential of Activatable Shiga Toxin 2d-Producing Escherichia coli Isolates from Fresh Produce. J Food Prot. 2015 Nov;78(11):2085-8.

Melton-Celsa AR, O'Brien AD. New Therapeutic Developments against Shiga Toxin-Producing Escherichia coli. Microbiol Spectr. 2014 Oct;2(5). doi: 10.1128/microbiolspec.EHEC-0013-2013.

Boisen N, Melton-Celsa AR, Scheutz F, O'Brien AD, Nataro JP. Shiga toxin 2a and Enteroaggregative Escherichia coli--a deadly combination. Gut Microbes. 2015 Jul 4;6(4):272-8.

Melton-Celsa AR, Carvalho HM, Thuning-Roberson C, O'Brien AD. Protective efficacy and pharmacokinetics of human/mouse chimeric anti-Stx1 and anti-Stx2 antibodies in mice. Clin Vaccine Immunol. 2015 Apr;22(4):448-55.

Melton-Celsa AR. Shiga Toxin (Stx) Classification, Structure, and Function. Microbiol Spectr. 2014 Aug;2(4):EHEC-0024-2013.

Zangari T, Melton-Celsa AR, Panda A, Smith MA, Tatarov I, De Tolla L, O'Brien AD. Enhanced virulence of the Escherichia coli O157:H7 spinach-associated outbreak strain in two animal models is associated with higher levels of Stx2 production after induction with ciprofloxacin. Infect Immun. 2014 Dec;82(12):4968-77.

Boisen N, Hansen AM, Melton-Celsa AR, Zangari T, Mortensen NP, Kaper JB, O'Brien AD, Nataro JP. The presence of the pAA plasmid in the German O104:H4 Shiga toxin type 2a (Stx2a)-producing enteroaggregative Escherichia coli strain promotes the translocation of Stx2a across an epithelial cell monolayer. J Infect Dis. 2014 Dec 15;210(12):1909-19.

Russo LM, Melton-Celsa AR, Smith MA, Smith MJ, O'Brien AD. Oral intoxication of mice with Shiga toxin type 2a (Stx2a) and protection by anti-Stx2a monoclonal antibody 11E10. Infect Immun. 2014 Mar;82(3):1213-21.

Zumbrun SD, Melton-Celsa AR, O'Brien AD. When a healthy diet turns deadly. Gut Microbes. 2014 Jan-Feb;5(1):40-3.