Edward Mitre

M.D.

Department of Primary Appointment:
School of Medicine
Microbiology and Immunology
Location: Uniformed Services University of the Health Sciences, Bethesda, MD
Research Interests:
Immunology, Host Defenses
Basic Biology of Bacterial, Viral, or Parasite Diseases
Office Phone

Education

2001 Infectious Diseases Fellowship, NIAID, NIH, Bethesda, MD
1998 Internal Medicine Residency, New York University, New York, NY
1995 M.D., Johns Hopkins University School of Medicine, Baltimore,
1991 B.A., Biology, Columbia University, New York, NY

Biography

Edward Mitre is a Professor in the Department of Microbiology and Immunology at the Uniformed Services University (USU) in Bethesda, Maryland. He obtained his medical degree from the Johns Hopkins School of Medicine in 1995 and then completed an internal medicine residency at New York University, where he served as the senior chief resident from 1998-1999. He completed an infectious diseases fellowship at the National Institutes of Health from 1999-2002, followed by post-doctoral research work in helminth immunology as well as clinical training in tropical medicine at the Laboratory of Parasitic Diseases at NIH. He teaches a variety of classes in parasitology, mycology, and bacteriology at the USU School of Medicine, and he co-directs the Molecular Parasitology and Models of Emerging Infectious Diseases graduate student courses. Dr. Mitre’s laboratory studies the immunology and pathogenesis of host responses to infectious and inflammatory diseases, with a focus on filarial nematode infections and allergy and, since 2020, SARS-CoV-2. Dr. Mitre is the primary investigator of the Prospective Assessment of SARS-CoV-2 Seroconversion study, a prospective study assessing how baseline immune factors affect clinical and immunological outcomes to SARS-CoV-2 infection and vaccination. In addition to his research and teaching responsibilities at USU, Dr. Mitre is a clinical faculty member of the Infectious Diseases Division at Walter Reed National Military Medical center, where he regularly attends on the internal medicine and infectious diseases services.

Representative publications, projects, and/or deployments

Lindrose, A.R., Mitra, I. Fraser, J., Mitre, E., and Hickey, P.W., “Helminth infections in the United States military: from strongyloidiasis to schistosomiasis.” Journal of Travel Medicine, 2021 Jan 22:taab004.

Jackson-Thompson BM, Torrero M, Mitre BK, Long J, Packiam M, and Mitre E., “Axenic Caenorhabditis elegans antigen protects against development of type-1 diabetes in NOD mice.” Journal of Translational Autoimmunity, 2020, August 16;3:100065.

Kropp, L., Jackson-Thompson, B., Thomas, L.M., McDaniel, D., and Mitre, E. “Chronic infection with a tissue invasive helminth attenuates sublethal anaphylaxis and reduces granularity and number of mast cells” Clinical and Experimental Allergy, 2020, 50(2):213-221.

Flynn A.F., Joyce, M.G., Taylor, R.T., Bennuru, S. Lindrose, A.R., Sterling S.L., Morris, C.P., Nutman, T.B., and Mitre, E. “Intestinal UDP-glucuronosyltransferase as a potential target for the treatment and prevention of lymphatic filariasis.” PLOS Neglected Tropical Diseases, 2019, Sep 12,; 13(9):e0007687.

Jackson, B.M., Kim, S.Y, Jaiswal, S., Scott, J., Jones, S., Morris, C.P., Fite, J.J., Laurie, K., Dardzinski, B., and Mitre, E., “Brugia malayi infection in ferrets – a small mammal disease model of lymphatic filariasis” PLOS Neglected Tropical Diseases, 2018, 12(3):e0006334.

Mitre, E., Susi, A., Kropp, L.E., Schwartz, D.J., Gorman, G.H., and Nylund, C.M. “Acid-suppressive medications and antibiotics during infancy are associated with allergic diseases in early childhood.” JAMA Pediatrics, 2018, June 4;172(6):e180315.

Evans, H. and Mitre, E., “Worms as therapeutics for allergy: understanding why benefits in animal studies have not translated into clinical success.” Journal of Allergy and Clinical Immunology, 2015, 135(2):343-53.

Evans, H., Killoran, K.E., Mitre, B.K., Smith, M.A., Morris, C.P., Kim, S. and Mitre, E. “Ten weeks of infection with a tissue-invasive helminth protects against immune complex-mediated inflammation but not clinical type I hypersensitivity in previously sensitized mice.” Journal of Immunology, 2015, 195(7):2973-84.

Hübner, M.P., Shi, Y., Torrero, M.N., Mueller, E., Larson, D., Soloviova, K., Gondorf, F., Hoerauf, A., Killoran, K.E., Stocker, J.T., Davies, S.J., Tarbell, K.V., and Mitre, E. “Helminth protection against autoimmune diabetes in NOD mice is independent of a type 2 immune shift and requires TGFβ.” Journal of Immunology, 2012, 188:559-568.

Bibliography

Commendation Letter from Major General Jeffrey B. Clark, U.S. Army, on behalf of Walter Reed National Military Medical Center, “For meritorious service while serving as a health care provider to a critically ill and complex patient in the Medical ICU" 2016

Outstanding Lecturer of the Preclinical Years (USU SOM classes of 2009, 2012, 2016-18)

Outstanding Civilian Educator Award, USU SOM class of 2016

Chair, American Society of Tropical Medicine and Hygiene Young Investigator Competition 2016-present (member and judge, 2008-15)

Associate Editor PLoS Pathogens 2014-present

Chair, Filariasis Section, American Society of Tropical Medicine and Hygiene Annual Meeting Committee, 2010-2013 (member 2007-2009)

Senior Chief Resident in Internal Medicine, New York University, 1998-1999