Mark Haigney MD

Education

B.A.: University of Virginia, Charlottesville, VA
MD: Vanderbilt University School of Medicine, Nashville, TN
Post-doctoral training: Johns Hopkins Hospital, Baltimore, MD

Biography

Dr. Haigney is a board-certified cardiologist and electrophysiologist who attends in the Cardiology and Cardiogenetics clinics at the Walter Reed National Military Medical Center. He is the Director of the Defense Health Agency-funded Military Cardiovascular Outcomes Research (MiCOR) program. The MiCOR research portfolio includes 20 clinical research projects intended to understand the impact of military service- particularly inherited syndromes, stress, weight-gain, exercise, COVID-19 infection, sleep disordered breathing, combat injury, and pharmacotherapy- on cardiovascular risk. Dr. Haigney collaborates with USU geneticists and the Armed Forces Medical Examiners Service to provide post-mortem clinical assessment and genetic testing to the victims of sudden cardiac arrest in the military and their families. He is co-chair of the AHA/ACC scientific statement on the cardiovascular care of the tactical athlete including military personnel, fire-fighters, law enforcement, and astronauts. The Cardiovascular Laboratory at Uniformed Services University is primarily concerned with identifying mechanisms of sudden cardiac death, including those related to genetically transmitted arrhythmia syndromes. The lab combines basic and clinical investigations in a translational approach using inducible pluripotent stem cell derived myocytes and heterologous cells to understand the mechanisms of cardiac arrest in human subjects.

Career Highlights: Positions, Projects, Deployements, Awards and Additional Publications

2024-6 Co-chair of AHA/ACC Scientific Statement on the Care of the Tactical Athlete with Cardiovascular Disease

2023 Editor-in-chief, Annals of Noninvasive Electrocardiology

2019 Director of Military Cardiovascular Outcomes Research program

2015-6 Chair, National American Heart Association Cardiac Electrophysiology- Clinical Peer Review Study Group,

DSMB Member MADIT RIT, MADT CHIC, JAVA CRT, WR1877, WR1849, Chair DSMB REPEAT-AF

2014- 2018 Treasurer, International Society for Holter and Noninvasive Electrocardiology

2016 Civilian Educator of the Year, School of Medicine, Uniformed Services University

2013 Carol J Johns Medal for University Service

Representative Bibliography

Zhang Z, Green JT, Haigney MC, Walker P, Shivkumar K, Garfinkel A, Qu Z. Methadone Blockade of Inward Rectifier Potassium Current Promotes Both Early and Delayed Repolarization Arrhythmias: Mechanistic Insights From Computational Modeling. J Am Heart Assoc. 2025 Oct 7;14(19):PMID: 40996098.

Petek BJ, Chung EH, Kim JH, Smith DL, Kales SN, Baggish AL, Franzos MA, Haigney MC, Levine BD, Dineen EH. Cardiovascular Care of Tactical Athletes: Have We Landed Yet? JACC Adv. 2024 Aug 30;3(10):101236. doi: 10.1016/j.jacadv.2024.101236. PMID: 39280796; PMCID: PMC11402179.

Nazari MA, Hasan R, Haigney M, Maghsoudi A, Lenders JWM, Carey RM, Pacak K. Catecholamine-induced hypertensive crises: current insights and management. Lancet Diabetes Endocrinol. 2023 Nov 6:S2213-8587(23)00256-5. PMID: 37944546

Solhjoo S, Punjabi NM, Ivanescu AE, Crainiceanu C, Gaynanova I, Wicken C, Buckenmaier C 3rd, Haigney MC. Methadone Destabilizes Cardiac Repolarization during Sleep. Clinical Pharmacology & Therapeutics. 2021 Jul 19. doi: 10.1002/cpt.2368. PMID: 34287835

Krantz MJ, Palmer RB, Haigney MC. Cardiovascular Complications of Opioid Use: JACC State-of- the-Art Review. J Am Coll Cardiol. 2021 Jan 19;77(2):205-223. doi:10.1016/j.jacc.2020.11.002. PMID: 33446314

Magee C, Haigney MC. Cardiovascular Screening in the US Military: Time to Reconsider the Electrocardiogram. Mil Med. 2020 Feb 17. pii: usaa002. doi: 10.1093/milmed/usaa002. PMID: 32065233

Geiger R, Klein MG, Fatima N, Krantz M, Haigney MC, Flagg T. Rapid Assessment of Proarrhythmic Potential using Human iPSC-Derived Cardiomyocytes. JACC Clin Electrophysiol. 2020;6(14):1860- 1862. doi: 10.1016/j.jacep.2020.08.034. PMID: 33357585

Nazari MA, Rosenblum JS, Haigney MC, Rosing DR, Pacak K. Current Views: Pathophysiology and Acute Management of Tachyarrhythmias in Pheochromocytoma. J Am Coll Cardiol. 2020 Jul 28;76(4):451-464. doi: 10.1016/j.jacc.2020.04.080. PMID: 32703516

Zareba W, Daubert JP, Beck CA, Huang DT, Alexis JD, Brown MW, Pyykkonen K, McNitt S, Oakes D, Feng C, Aktas MK, Ayala-Parades F, Baranchuk A, Dubuc M, Haigney M, Mazur A, McPherson CA, Mitchell LB, Natale A, Piccini JP, Raitt M, Rashtian MY, Schuger C, Winters S, Worley SJ, Ziv O, Moss AJ; RAID Trial Investigators. Ranolazine in High-Risk Patients With Implanted Cardioverter- Defibrillators: The RAID Trial. JACC 2018 72(6):636-645

Klein MG, Shou M, Stohlman J, Solhjoo S, Haigney M, Tidwell RR, Goldstein RE, Flagg TP, Haigney MC. Role of suppression of the inward rectifier current in terminal action potential repolarization in the failing heart. Heart Rhythm. 2017. PMID: 28396172