Mark C. Haigney
EducationBA: University of Virginia, Charlottesville, VA
MD: Vanderbilt University School of Medicine, Nashville, TN
Post-doctoral training: Johns Hopkins Hospital, Baltimore, MD
BiographyDr. Haigney is a board certified cardiologist and electrophysiologist who attends in the Walter Reed Cardiology and Genetic Cardiology clinics. The Haigney Cardiovascular Laboratory is primarily concerned with identifying mechanisms of sudden cardiac death, including those related to genetically transmitted arrhythmia syndromes. The lab combines basic and clinical investigations in a translational approach. A tachycardia-pacing model of large animal heart failure has been in place for ten years and has allowed evaluation of specific ion channels and their alteration by heart failure. The clinical research component has evaluated a number of approaches to prediction of arrhythmic events, with particular emphasis on unstable repolarization as manifest by QT interval variability. The laboratory has investigated the use of inducible pluripotent stem cell derived myocytes to understand the mechanisms of cardiac arrest in human subjects. Dr Haigney is the Director of the newly-established Military Cardiovascular Outcomes Research (MiCOR), a program intended to understand the impact of military service- particularly stress, weight-gain, exercise, and pharmacotherapy- on cardiovascular risk. He is the Deputy Director of the Collaborative Health Initiative Research Program (CHIRP), an NIH and DoD sponsored center for evaluating genomics in the military health system. Dr. Haigney is particularly interested in iatrogenic factors contributing to sudden death, including the impact of prescription medications, particularly synthetic opioids, and sympathomimetic supplements.
Office A3060, Hebert School of Medicine, 4301 Jones Bridge Road, Bethesda MD 20814
For appointments, please contact my Administrative Assistant: 301-295-3617
For appointments in the Genetic Cardiology Clinic at Walter Reed, please call 301-295-4939
Representative publications, projects, and/or deployments
2013 Carol Johns Medal for Service, Uniformed Services University
2016 Civilian Educator of the Year, School of Medicine, Uniformed Services University
2014- 2018 Treasurer, International Society for Holter and Noninvasive Electrocardiology
2015-6 Chair, National American Heart Association Cardiac Electrophysiology- Clinical Peer Review Study Group,
2013--9 American College of Cardiology, National Cardiovascular Data Registry on Implantable Defibrillator, Research and Publication Committee
DSMB Member MADIT RIT, MADT CHIC, JAVA CRT, WR1877, WR1849
Klein MG, Shou M, Stohlman J, Solhjoo S, Haigney M, Tidwell RR, Goldstein RE, Flagg TP, Haigney MC. Role of suppression of the inward rectifier current in terminal action potential repolarization in the failing heart. Heart Rhythm. 2017. PMID: 28396172
Lin Y, Linask KL, Mallon B, Johnson K, Klein M, Beers J, Xie W, Du Y, Liu C, Lai Y, Zou J, Haigney M, Yang H, Rao M, Chen G. Heparin Promotes Cardiac Differentiation of Human Pluripotent Stem Cells in Chemically Defined Albumin-Free Medium, Enabling Consistent Manufacture of Cardiomyocytes. Stem Cells Transl Med. 2017 Feb;6(2):527-538. PMID: 28191759
Zareba W, Daubert JP, Beck CA, Huang DT, Alexis JD, Brown MW, Pyykkonen K4, McNitt S, Oakes D, Feng C, Aktas MK, Ayala-Parades F, Baranchuk A, Dubuc M, Haigney M, Mazur A, McPherson CA, Mitchell LB, Natale A, Piccini JP, Raitt M, Rashtian MY, Schuger C, Winters S, Worley SJ, Ziv O, Moss AJ; RAID Trial Investigators. Ranolazine in High-Risk Patients With Implanted Cardioverter-Defibrillators: The RAID Trial. JACC 2018 72(6):636-645
Fatima N, Devin C. Cohen, Gauthaman Sukumar, Tristan M. Sissung, James F. Schooley, Jr., Mark C. Haigney, William C. Claycomb, Rachel T. Cox, Clifton L. Dalgard, Susan E. Bates, and Thomas P. Flagg. Histone deacetylase inhibitors modulate KATP subunit transcription in HL-1 cardiomyocytes through effects on cholesterol homeostasis. Frontiers in Pharmacology 2015 6 1-9.
Kao D, Haigney M, Mehler P, Krantz M. Arrhythmia Associated with Buprenorphine and Methadone Reported to the Food and Drug Administration. Addiction 2015 Sep;110(9):1468-75.
Klein MG, Haigney MCP, Mehler PS, Fatima N, Flagg TP, Krantz MJ. Potent Inhibition of hERG Channels by the Over-the-Counter Antidiarrheal Agent Loperamide. JACC Clin Electrophysiol. 2016;2(7):784-789
Mark Haigney, Wojceich Zareba, Maria Teresa La Rovere, Ian Grasso, David Mortara. Assessing the Interaction of Respiration and Heart Rate in Heart Failure and Controls Using Ambulatory Holter Recordings. J ECG, in press. PMID: 25172186
Chou R, Inturisi C, Feillin D, Haigney M, Walsh S. Methadone Safety: A Clinical Practice Guideline from the American Pain Society and College on Problems of Drug Dependence. J Pain. 2014;15(4):321-37.
Goldstein RE, Haigney MC, Krone R, Mcnitt S, Zareba W, Moss AJ. Differing Effects of Cardiac Resynchronization Therapy on Long-term Mortality in Patient Subgroups of MADIT-CRT Defined by Baseline Conduction and One-Year Post-Treatment Left Ventricular Remodeling. Heart Rhythm. 2013 Mar;10(3):366-73.
Dobson, C, Olsen C, LaRovere MT, Bernardinangeli M, Veniani M, Midi P, Tavazzi L, Haigney M. QT Variability Index on 24-Hour Holter Independently Predicts Mortality in Patients with Heart Failure: Analysis of GISSI-HF Trial Data. Heart Rhythm, 2011;8(8):1237-42.