Department of Primary Appointment:
School of Medicine
Anatomy, Physiology and Genetics
Uniformed Services University of the Health Sciences, Bethesda, MD
Mechanism of regulation of Inflammation in Lung Diseases
Ph.D., The Ohio State University, 1997
Chronic diseases and even aging itself are known to damage the body by dys-regulated inflammatory processes. Dysregulated expression of the pro-inflammatory cytokine and chemokine genes are known to contribute to chronic inflammatory diseases. Recently, endogenous non-coding RNA (ncRNA) molecules, including long non-coding RNAs (LncRNAs) and microRNAs (miRNAs, miRs) have emerged as important targets in the frontier of biomedical research. These non-coding RNAs have been proven to be key regulators of gene expression. The ability to detect non-coding RNAs in biofluids has highlighted their usefulness as non-invasive markers of diseases, including lung diseases. The expression of specific non-coding RNAs is altered in many lung diseases and their levels in the circulation often reflect the changes in expression of their lung-specific counterparts. Therefore, exploiting these biomolecules as diagnostic tools seems an obvious goal. Our goal is to investigate the role of non-coding RNAs in Cystic Fibrosis lung disease and develop novel anti-inflammatory therapeutics for pulmonary disorders.