Sara K. Young-Baird

Ph.D.

Department of Primary Appointment:
School of Medicine
Biochemistry
Title
Assistant Professor (Tenure-Track)
Location: Uniformed Services University of the Health Sciences, Bethesda, MD
Research Interests:
Regulation of protein synthesis
Cellular stress and disease
Office Phone

Education

B.S. in Biology, Indiana University, 2010
Ph.D. in Biochemistry and Molecular Biology, Indiana University School of Medicine, 2016
Postdoctoral Fellowship, Protein Biosynthesis, National Institutes of Health, 2021

Representative Bibliography

Young-Baird SK. Pumping the brakes: A noncanonical RNA-binding domain in FMRP stalls elongating ribosomes. J Biol Chem. 2023 Jan;299(1):102773.

Doty RT, Fan X, Young DJ, Liang J, Singh K, Pakbaz Z, Desmond R, Young-Baird SK, Chandrasekharappa SC, Donovan FX, Phelps SR, Winkler T, Dunbar CE, Abkowitz JL. Studies of a mosaic patient with DBA and chimeric mice reveal erythroid cell-extrinsic contributions to erythropoiesis. Blood. 2022 Jun 9;139(23):3439-3449.

Young-Baird SK*, Louren├žo MB, Elder MK, Klann E, Liebau S, Dever TE*. Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB. Mol Cell. 2020 Feb 20;77(4):875-886. *co-corresponding authors.

Kotzaeridou U*, Young-Baird SK*, Suckow V, Thornburg AG, Wagner M, Harting I, Christ S, Strom T, Dever TE, Kalscheuer VM. Novel pathogenic EIF2S3 missense variants causing clinically variable MEHMO syndrome with impaired eIF2╬│ translational function, and literature review. Clin Genet. 2020 Nov;98(5):507-514. *co-first authors.

Young-Baird SK, Shin BS, Dever TE. MEHMO syndrome mutation EIF2S3-I259M impairs initiator Met-tRNAiMet binding to eukaryotic translation initiation factor eIF2. Nucleic Acids Res. 2019 Jan 25;47(2):855-867.

Young SK, Wek RC. Upstream Open Reading Frames Differentially Regulate Gene-specific Translation in the Integrated Stress Response. J Biol Chem. 2016 Aug 12;291(33):16927-35.

Young SK, Shao Y, Bidwell JP, Wek RC. Nuclear Matrix Protein 4 Is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response via Repression of Gadd34 Expression. J Biol Chem. 2016 Jun 24;291(26):13780-8.

Young SK*, Baird TD*, Wek RC. Translation Regulation of the Glutamyl-prolyl-tRNA Synthetase Gene EPRS through Bypass of Upstream Open Reading Frames with Noncanonical Initiation Codons. J Biol Chem. 2016 May 13;291(20):10824-35. *co-first authors.

Young SK, Palam LR, Wu C, Sachs MS, Wek RC. Ribosome Elongation Stall Directs Gene-specific Translation in the Integrated Stress Response. J Biol Chem. 2016 Mar 18;291(12):6546-58.

Young SK, Willy JA, Wu C, Sachs MS, Wek RC. Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response. J Biol Chem. 2015 Nov 20;290(47):28257-28271.