Xin Xiang

Ph. D.

Department of Primary Appointment:
School of Medicine
Biochemistry
Title
Professor
Location: Uniformed Services University of the Health Sciences, Bethesda, MD
Research Interests:
Cell biology, intracellular transport, motor proteins
Genetics, fungi, Aspergillus nidulans
Office Phone

Education

B.S. & M.S. Department of Biology, Peking University, Beijing, P. R. China
Ph.D. Department of Biochemistry, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey. Advisor: Dr. Kiran Chada.
Post-doctoral research: Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey. Advisor: Dr. Ron Morris.

Biography

2012- Professor, Department of Biochemistry and Molecular Biology, the Uniformed Services University of the Health Sciences-F. Edward Hébert School of Medicine
2004-2012 Associate Professor, Department of Biochemistry and Molecular Biology, the Uniformed Services University of the Health Sciences-F. Edward Hébert School of Medicine
1999-2004 Assistant professor, Department of Biochemistry and Molecular Biology, the Uniformed Services University of the Health Sciences-F. Edward Hébert School of Medicine

Representative publications, projects, and/or deployments

Xiang, X. and Qiu, R. (2020) Cargo-mediated activation of cytoplasmic dynein in vivo (review). Frontiers in Cell and Developmental Biology 23 October 2020 | https://doi.org/10.3389/fcell.2020.598952 (Research Topic: Energy Requirements in Membrane Trafficking. Editor: C.M. Guardia)

Xiang, X. (2018) Insights into Cytoplasmic Dynein Function and Regulation from Fungal Genetics (book chapter), in: S. M. King (Ed.) Dyneins: Structure, Biology and Disease: The Biology of Dynein Motors, vol. 1, Academic Press, Elsevier, 2018, pp. 470-501.

Xiang, X. (2018) Nuclear Movement in fungi (review). Seminars in Cell and Developmental Biology: in the special issue "Nuclear positioning" (Guest Editor: B. Cadot), 82:3-16.

Xiang, X, Qiu, R., Yao, X., Arst, H.N. Jr, Peñalva, M.A. and Zhang, J. (2015) Cytoplasmic dynein and early endosome transport (review). Cellular and molecular life sciences 72, 3267-3280. PMCID: PMC4534323

Xiang, X. (2012) Nuclear positioning: dynein needed for microtubule shrinkage-coupled movement. Curr. Biol. 22 (12), R496-R499.

Xiang, X. and Oakley, B. R. (2010). The Cytoskeleton in Filamentous Fungi (book chapter). In: Cellular and Molecular Biology of Filamentous Fungi (Edited by K. Borkovich and D. Ebbole), ASM Press. p209-223.

Xiang, X. (2006) A +TIP for a smooth trip. (minireview) J. Cell Biol. 172, 651-654.

Current grant support: RO1, NIH/NIGMS "Regulation of cytoplasmic dynein in vivo" (2017-2021).

USUHS Awards (2017): Henry Wu award for excellence in the basic sciences; Medical School Dean's Impact award recognizing excellence in research.

2019 Fellow of the American Society for Cell Biology

Bibliography

Qiu, R., J. Zhang, and X. Xiang. (2020) The splicing-factor Prp40 affects dynein-dynactin function in Aspergillus nidulans. Mol. Biol. Cell, 31:1289-1301.

Qiu, R., Zhang, J., Xiang, X. (2019) LIS1 regulates cargo-adapter-mediated activation of dynein by overcoming its auto-inhibition in vivo. J. Cell Biol. 218, 3630-3646.

Qiu, R., J. Zhang, and X. Xiang. (2018) p25 of the dynactin complex plays a dual role in cargo binding and dynactin regulation. J Biol Chem. 293:15606-15619.

Zhang, J., R. Qiu, and X. Xiang. (2018) The actin capping protein in Aspergillus nidulans enhances dynein function without significantly affecting Arp1 filament assembly. Scientific reports. 8:11419.

Yao, X., Arst, H, Wang, X. and Xiang, X. (2015) Discovery of a vezatin-like protein for dynein-mediated early endosome transport. Mol. Biol. Cell. 26, 3816-3827 (highlighted by MBoC). PMCID: PMC4626066

Yao, X., Wang, X. and Xiang, X. (2014) FHIP and FTS proteins are critical for dynein-mediated transport of early endosomes in Aspergillus. Mol. Biol. Cell. 25, 2181-2189 (highlighted by MBoC). PMCID: PMC4091831

Zhang, J., Qiu, R., Arst, H.N. Jr, Peñalva, M.A. and Xiang, X. (2014) HookA is a novel dynein-early endosome linker critical for cargo movement in vivo. J. Cell Biol., 218:3630-3646. 204, 1009-1026 PMCID: PMC3998793. (highlighted by JCB In Focus and by Nat. Rev. Mol. Cell Biol in Res. Highlights).

Zhang, J., Yao, X., Fischer, L. Abenza J. F., Peñalva. M. A., Xiang, X. (2011) The p25 subunit of the dynactin complex is required for dynein-early endosome interaction. J. Cell Biol. 193, 1245-1255. PMCID:PMC3216330

Zhang, J., Li, S., Fischer, R. and Xiang, X. (2003) Accumulation of cytoplasmic dynein and dynactin at microtubule plus ends in Aspergillus nidulans is kinesin dependent. Mol. Biol. Cell 14, 1479-1488.

Han, G., Liu, B., Zhang, J., Zuo W., Morris, N. R. and Xiang, X. (2001) The Aspergillus cytoplasmic dynein heavy chain and NUDF localize at the microtubule ends and affect microtubule dynamics. Curr. Biol. 11, 719-724.