Education2000 Ph.D., Texas Tech University Health Sciences Center (TTUHSC), Department of Cell Biology and Biochemistry, Lubbock, TX
BiographyDr. Du is a molecular biologist and mouse geneticist who is interested in mechanisms responsible for the development of leukemia. He received his Ph.D. in Medical Biochemistry from Texas Tech University Health Sciences Center, where he studied transcription regulation of hematopoietic development in Dr. Simon Williams laboratory. He later joined the laboratory of Drs. Neal Copeland and Nancy Jenkins in the Mouse Cancer Genetics Program at National Cancer Institute-Frederick as a postdoctoral fellow to study leukemia development using mouse models.
Representative publications, projects, and/or deployments
2005 Fellows Award for Research Excellence (FARE), National Institutes of Health
1998 Faculty Award, Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center
Nguyen N, Oakley K, Han Y, Kwok M, Crouch G, Du Y. Interaction with XPO1 is essential for SETBP1 to induce myeloid transformation. Leukemia 2019 Jul 23.
Vishwakarma BA, Gudmundsson KO, Oakley K, Han Y, Du Y. Insertional mutagenesis identifies cooperation between Setbp1 and Mllt3 in inducing myeloid leukemia development. Leukemia 2019 Mar 20.
Negi V., Vishwakarma B. A., Chu S., Oakley K., Han Y., Bhatia R., and Du Y. Hoxa9 and Hoxa10 induce CML myeloid blast crisis development through activation of Myb expression. (2017) Oncotarget 8:98853-64.
Nguyen N., Oakley K., Vishwakarma B. A., Han Y., Przychodzen B., Maciejewski J. P., and Du Y. (2016). Myb expression is critical for myeloid leukemia development induced by Setbp1 activation. Oncotarget, 10.18632/oncotarget. 13383.
Vishwakarma, B. A., Nguyen, N., Makishima, H., Hosono, N., Gudmundsson, K. O., Negi, V., Oakley, K., Han, Y., Przychodzen, B., Maciejewski, J. P., and Du, Y. (2016). Runx1 repression by histone deacetylation is critical for Setbp1-induced mouse myeloid leukemia development. Leukemia, 30(1), 200-208.
Makishima, H., et al. (2013). Somatic SETBP1 mutations in myeloid malignancies. Nature genetics 45, 942-946.
Oakley, K., Han, Y., Vishwakarma, B. A., Chu, S., Bhatia, R., Gudmundsson, K., Keller, J., Chen, X., Vasko, V., Jenkins, N. A., Copeland, N. G., and Du, Y. (2012). Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10. Blood, 119(25), 6099-6108.
Aue, G*, Du, Y.*, Cleveland, S. M., Smith, S. B., Davé, U. P., Liu, D., Metais, J. Y., Jenkins, N. A., Copeland, N. G., and Dunbar, C. E. (* Co-first author) (2011). Sox4 cooperates with Pu.1 haploinsufficiency in murine myeloid leukemia. Blood, 118(17), 4674-4681.
Du, Y., Jenkins, N. A., and Copeland, N. G. (2005). Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells. Blood, 106(12), 3932-3939.
Du, Y., Spence, S. E., Jenkins, N. A., and Copeland, N. G. (2005). Cooperating cancer gene identification via oncogenic retrovirus-induced insertional mutagenesis. Blood, 106(7), 2498-2505.