William H. Catherino

M.D., Ph.D.

Department of Primary Appointment:
School of Medicine
Gynecologic Surgery and Obstetrics
Professor and Vice Chair-Research
Location: Uniformed Services University of the Health Sciences, Bethesda, MD
Research Interests:
Reproductive Endocrinology and Infertility / Obstetrics and Gynecology
Uterine Fibroids
Office Phone


B.S. (Honors): University of Michigan
M.D. (AOA): University of Wisconsin-Madison
Ph.D.: University of Wisconsin-Madison
Residency (OBG): Duke University
Fellowship (REI): National Institutes of Health


Dr. Catherino graduated from the University of Michigan (High Honors and High Distinction) with a Bachelors of Science and the University of Wisconsin-Madison (Alpha Omega Alpha) with M.D. and Ph.D. degrees. He completed his Obstetrics and Gynecology Residency at Duke University Medical Center and his Reproductive Endocrinology and Infertility fellowship at the Combined Federal Fellowship (NIH, WRAMC, NNMC, USUHS). After completing his fellowship, he joined the faculty at the Uniformed Services University of the Health Sciences, while providing patient care at WRNMMC and the NIH. Additionally, he completed additional scholarly training as part of the American Association of Obstetricians and Gynecologists Foundation.

During his 19 years in the Department of Gynecologic Surgery and Obstetrics at the Uniformed Services University, Dr. Catherino served in a variety of clinical, research, and academic roles including Associate Program Director of the Reproductive Endocrinology and Infertility fellowship, mentor to over 80 scientists at all levels of their training (from high school to post-graduate level), and as a National Faculty Educator for USUHS . He currently serves on the M.D., Ph.D. advisory committee and teaches courses for medical students, residents, and clinical fellows.

Academically, he holds the rank of Professor of Obstetrics and Gynecology with tenure at USU and he has authored or co-authored over 100 peer-reviewed manuscripts. He has numerous teaching accolades, and is sought out to provide unique exposure to the science, medicine, and ethics of his field. Internationally, he has record of outstanding service to learners at all educational levels.

Career Highlights: Positions, Projects, Deployements, Awards and Additional Publications

Editor-in-Chief, Fertility & Sterility - Science

Division Member, Reproductive Endocrinology & Infertility, American Board of Obstetrics and Gynecology

Chair, American Association of Obstetricians and Gynecologists Foundation Scholars

Member, Career Development Committee, Society for Reproductive Investigation

Member, Milestones Working Group, Accreditation Council for Graduate Medical Education

Past-Chair, Physician-Scientist Special Interest Group, American Society for Reproductive Medicine

Past-Chair, Committee on Appointments, Promotion and Tenure (USUHS)

Past-Chair, Fibroid Special Interest Group (ASRM)

Oral Boards Examiner and Question Writer for Oral and Written Exam (ABOG)

Chair, Content Review Committee, American Society for Reproductive Medicine

Representative Bibliography

Malik M, Britten JL, DeAngelis A, Sitler C, Moran S, Roura-Monillor JA, Driggers P, Catherino WH. Curcumin inhibits human leiomyoma xenograft tumor growth and induces dissolution of extracellular matrix. Fert Stert Sci 2022;S2666-335X(22)00066-0. PMID [36273722]

Wright D, Kim JW, Lindsay H, Catherino WH. A review of GnRH antagonists as treatment for abnormal uterine bleeding-leiomyoma (AUB-L) and their influence on the readiness of service members. Mil Med 2022;usac078. PMID [35348746]

Singh SS, Calaf Alsina J, Vannuccini S, Koga K, Lopes Silva-Filho A, Yang X, Estrade JP, Catherino WH. Clinical perspectives on the menstrual pictogram for the assessment of heavy menstrual bleeding. Hum Reprod Open 2022;2022hoac048. PMID [36382010]

Wright D, Britten J, Malik M, Catherino WH. Relugolix & elagolix directly inhibit leiomyoma extracellular matrix production in 2-dimensional and 3-dimensional cell cultures. Fert Stert Sci 2022;3:299-308. PMID [35977805]

DeAngelis AM, Malik M, Britten J, Driggers P, Catherino WH. Carcinoembryonic antigen-related cell adhesion molecule 1: a key regulatory protein involved in leiomyoma growth. Fertil Steril Sci 2021;2:396-406. PMID [35559862]

Bateman NW, Tarny C, Abulez BS, Soltis AR, Zhou M, Conrads K, Litzi T, Oliver J, Hood B, Driggers P, Violete C, Dalgard C, Wilkerson M, Catherino W, Hamilton CA, Darcy KM, Casablanca Y, Al-Hendy A, Segars J, Conrads TP, Maxwell GL. Proteogenomic landscape of uterine leiomyomas from Hereditary leiomyomatosis and renal cell cancer patients. Nature Comm 2021;11:9371. PMID [33931688]

Britten JL, Malik M, Pekny C, DeAngelis A, Catherino WH. Three-dimensional human leiomyoma xenografts induce angiogenesis by inducing hypoxia inducible factor-1 alpha. Fertil Steril Sci 2021;2:219-27. PMID [35559755]

Malik M, Britten J, DeAngelis A, Catherino WH. Crosstalk between JAK/STAT and TGF-beta pathways and increased collagen1A1 production in uterine leiomyoma cells. Fertil Steril Sci 2020;2:206-20. PMID [35559929]

Afrin S, Islam S, Patzkowsky K, Malik M, Catherino WH, Segars JH, Borahay M. Simvastatin ameliorates altered mechanotransduction in uterine leiomyoma cells. Am J Obstet Gynecol 2020, 223:733.e1-733.e14. [PMID 32417359]

Pilgrim J, Arismendi J, DeAngelis A, Lewis T, Britten J, Malik M, Catherino WH. Characterization of the role of Activator Protein 1 (AP 1) signaling pathway on extracellular matrix deposition in uterine leiomyoma. Fertil Stertil Sci 2020;1:78-89. PMID [35559742]